5458-14-0

Usage

Uses

Used in Pharmaceutical Synthesis:
2-(TRIFLUOROACETAMIDO)ETHYLAMINE HYDROCHLORIDE is used as an intermediate in the synthesis of pharmaceuticals for its unique chemical properties that facilitate the creation of various medicinal compounds.
Used in Research and Development:
In the scientific community, 2-(TRIFLUOROACETAMIDO)ETHYLAMINE HYDROCHLORIDE is utilized as a research compound, allowing researchers to explore its potential applications and interactions within different chemical and biological systems.
Safety Considerations:
When handling 2-(TRIFLUOROACETAMIDO)ETHYLAMINE HYDROCHLORIDE, researchers must adhere to safety protocols due to its potential to cause eye irritation or skin reactivity, emphasizing the importance of proper protective measures during its use in laboratories and industrial settings.

InChI:InChI=1/C4H7F3N2O/c5-4(6,7)3(10)9-2-1-8/h1-2,8H2,(H,9,10)

Upstream product

• 383-63-1 ethyl trifluoroacetate, 
• 333-18-6 1,2-diaminoethane dihydrochloride 
• 107-15-3 ethylenediamine 
• 160502-09-0 tert-butyl (2-(2,2,2-trifluoroacetamido)ethyl)carbamate 

Downstream Products

• 496945-43-8 N-[2-[N-[3-[4-(N-tert-butoxycarbonylaminomethyl)phenyl]propyl]amino]ethyl]trifluoroacetamide 
• 53672-88-1 3-<<2-(trifluoroacetamido)ethyl>amino>-1-phenoxypropan-2-ol 

Relevant academic research and scientific papers

METHOD FOR PRODUCING IMIDAZOLINE COMPOUND

PROBLEM TO BE SOLVED: To provide a method for producing an imidazoline compound having high yield and small amount of impurity. SOLUTION: There is provided a method for producing an imidazoline compound (B) using a diamine monoamide compound (A) represented by the general formula (1), wherein the method includes a dehydration condensation step of the diamine monoamide compound (A) and a distillation step of the imidazoline compound (B). In the dehydration condensation step, the temperature of the dehydration condensation reaction of (A) is 100°C to 160°C in a time of 50% or more of the process time from when the conversion rate from (A) to (B) becomes 55% until when the conversion rate from (A) to (B) becomes 70%, and a the gas-phase pressure at the temperature of the dehydration condensation reaction of (A) is P1 which satisfies the conditions 1. In the distillation step, the temperature of the liquid containing (A) and (B) is 100°C to 190°C in a time of 50% or more of the process time from when 30 wt.% of the total distillate of (B) is distillated until when 90 wt.% of the total distillate of (B) is distillated, and a pressure (B) in the gas-phase of the distillation step is P2 which satisfies the condition 2. SELECTED DRAWING: None COPYRIGHT: (C)2021,JPOandINPIT

Green synthesis method of sitagliptin intermediate

The invention relates to a green synthesis method of sitagliptin intermediate, and belongs to the technical field of drug intermediate synthesis. In order to solve the problems that an existing pollution is large and unstable, a green synthesis method of sitagliptin intermediate is provided, and the method comprises the following steps: in an ether solvent, reacting trifluoroacetic acid ethyl ester with ethylenediamine to generate 2 - trifluoroacetamide ethyl ethylamine. Under the presence of an acid binding agent, 2 - trifluoroacetamide ethyl ethylamine and halogenated ethyl acetate are condensed and reacted under the conditions of 45 °C - 65 °C DEG C to form an intermediate, and then, the temperature is raised to 90 - 110 °C for cyclization reaction to generate N - trifluoroacetyl piperidine. The N -trifluoroacetyl piperidine ketone is reacted with hydrazine hydrate to generate 1 -trifluoroacetylamino -2 -piperazinone. The product is reacted with hydrochloric acid to form a ring-forming reaction, and a product sitagliptin intermediate is obtained. The method provided by the invention has the advantages of high product yield and purity on the whole, and has the advantage of environmental friendliness.

Multifunctional degradable nanoparticles with control over size and functionalities

In one aspect, the invention relates to polymers, crosslinked polymers, functionalized polymers, nanoparticles, and functionalized nanoparticles and methods of making and using same. In one aspect, the invention relates to degradable polymers and degradable nanoparticles. In one aspect, the invention relates to methods of preparing degradable nanoparticles and, more specifically, methods of controlling particle size during the preparation of degradable nanoparticles. In one aspect, the degradable nanoparticles are useful for complexing, delivering, and releasing payloads, including pharmaceutically active payloads. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

DENDRITIC MOLECULAR INTRACELLULAR TRANSPORTERS AND METHODS OF MAKING AND USING SAME

In accordance with the purpose(s) of the invention, as embodied and broadly described herein, the invention, in one aspect, relates to compounds comprising the structure: and at least one guanidinium residue, wherein m is zero or a positive integer. Also disclosed are methods of preparing the disclosed compounds. Also disclosed are methods of intracellular delivery comprising administering the disclosed compounds and compositions to a subject. Also disclosed are pharmaceutical compositions comprising a therapeutically effective amount of one or more compounds or compositions of the invention and a pharmaceutically acceptable carrier. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

High yield selective acylation of polyamines: Proton as protecting group

An advance in the selective acylation of polyamines having identical or similar amine functions is reported. While nucleophilicity differences between the various amine functions are slight, the corresponding conjugate acids exhibit pKa values

Ethyl trifluoroacetate: A powerful reagent for differentiating amino groups

Selective protection of primary amines in the presence of secondary amines and monofunctionalization of symmetric primary and secondary diamines using ethyl trifluoroacetate is described. Effective differentiation of primary, secondary and tertiary alkyl-substituted primary amines from one another by ethyl trifluoroacetate acylation is also demonstrated. These results are explained on the basis of steric and electronic effects of the substrate amines.