5462-06-6

Basic information

• Product Name: 2-METHYL-3-(PARA-METHOXY PHENYL)-PROPANAL
• Synonyms: 2-(p-Anisyl)propanal;2-Anisylpropional;2-Methyl-3-(4-methoxyphenyl)propionaldehyde;2-methyl-3-(p-methoxyphenyl)propanal;4-methoxy-.alpha.-methyl-Benzenepropanal;4-methoxy-alpha-methyl-benzenepropana;4-methoxy-alpha-methylbenzenepropanal;Benzenepropanal,4-methoxy-.alpha.-methyl-
• CAS NO: 5462-06-6
• Molecular Formula: C₁₁H₁₄O₂
• Molecular Weight: 178.23
• EINECS: 226-749-5
• Mol File: 5462-06-6.mol
• Article Data: 30

Chemical Properties

• Boiling Point: 270.46°C (rough estimate)
• Flash Point: 106.4°C
• Appearance: /
• Density: 1.0292 (rough estimate)
• Vapor Pressure: 0.0102mmHg at 25°C
• Refractive Index: 1.5103 (estimate)
• Water Solubility: 1.086g/L at 24℃
• CAS DataBase Reference: 2-METHYL-3-(PARA-METHOXY PHENYL)-PROPANAL(CAS DataBase Reference)
• NIST Chemistry Reference: 2-METHYL-3-(PARA-METHOXY PHENYL)-PROPANAL(5462-06-6)
• EPA Substance Registry System: 2-METHYL-3-(PARA-METHOXY PHENYL)-PROPANAL(5462-06-6)

Safety Data

• Hazardous Substances Data: 5462-06-6(Hazardous Substances Data)

Usage

Chemical Properties

2-METHYL-3-(PARA-METHOXY PHENYL)-PROPANA is a pale yellow liquid with licorice, anise note with slight fruity modification. It can be prepared by condensation of anisaldehyde with propanal and selective hydrogenation of the resulting 2-methyl-3-(4-methoxyphenyl)-2-propenal. It fits well with floral notes and is used in fine fragrances and cosmetics.

Flammability and Explosibility

Nonflammable

Trade name

Canthoxal (IFF)

InChI:InChI=1/C11H14O2/c1-9(8-12)7-10-3-5-11(13-2)6-4-10/h3-6,8-9H,7H2,1-2H3

Upstream product

• 64506-21-4 (+/-)-2-methyl-3-(p-methoxyphenyl)propanol 
• 77104-98-4 1-acetoxy-2-methyl-3-(4-methoxyphenyl)propene 
• 696-62-8 para-iodoanisole 
• 513-42-8 3-hydroxy-2-methyl-1-propene 
• 104-92-7 1-bromo-4-methoxy-benzene 
• 140-67-0 Estragole 
• 201230-82-2 carbon monoxide 
• 67-56-1 methanol 
• 64-18-6 formic acid 
• 7319-16-6 methyl prop-1-enyl ether 
• 2746-25-0 p-Methoxybenzyl bromide 
• 824-94-2 p-methoxybenzyl chloride 
• 105-13-5 4-Methoxybenzyl alcohol 
• 111-92-2 dibutylamine 

Downstream Products

• 79253-39-7 (S)-(-)-3-(4-methoxyphenyl)-2-methylpropan-1-ol 
• 1256556-38-3 (1S,3R,R)-3-(1-(4-methoxyphenyl)propan-2-yl)-1-phenyl-2,3-dihydro-1H-naphtho[1,2-e][1,3]oxazine 
• 52427-11-9 3-(4-methoxyphenyl)-2-methylpropionic acid 
• 1383713-49-2 5-(4-(4-methoxyphenyl)-3-methylbut-1-enyl)benzo[d][1,3]dioxole 
• 152236-02-7 Methanesulfonic acid 1-(benzenesulfinyl-chloro-methyl)-3-(4-methoxy-phenyl)-2-methyl-propyl ester 
• 152236-00-5 1-Benzenesulfinyl-1-chloro-4-(4-methoxy-phenyl)-3-methyl-butan-2-ol 

Relevant articles and documents

Method for preparing anethol propionaldehyde by anisole

The invention relates to the technical field of organic synthesis, in particular to a method for preparing anethoxyl propionaldehyde by anisole, which comprises anisole and 2 - methylallyl diacetate or anisole. 2 - Methacrolein and acetic anhydride were added to the reaction vessel to catalyze the reaction. Then 1 - acetoxy -2 - methyl -3 - (4 - methoxyphenyl) propylene was added to a reaction vessel carrying an alcoholic solvent and an ester exchange catalyst to carry out an ester exchange reaction. The method solves the problems that the cost of anisic aldehyde or anisaldehyde in the product is high due to the expensive price of anisaldehyde or anethol in the prior art, and anisole is synthesized into anethol propionaldehyde. The synthetic anisanylpropanal has a sufficiently high purity. Can be used for perfumery.

Carbonylative Transformation of Allylarenes with CO Surrogates: Tunable Synthesis of 4-Arylbutanoic Acids, 2-Arylbutanoic Acids, and 4-Arylbutanals

In this Communication, procedures for the selective synthesis of 4-arylbutanoic acids, 2-arylbutanoic acids, and 4-arylbutanals from the same allylbenzenes have been developed. With formic acid or TFBen as the CO surrogate, reactions proceed selectively and effectively under carbon monoxide gas-free conditions.

Rhodium/Phosphine catalysed selective hydroformylation of biorenewable olefins

This work reports rhodium catalyzed selective hydroformylation of natural olefins like eugenol, estragole, anethole, prenol and isoprenol using biphenyl based Buchwald phosphine ligands (S-Phos (L1), t-Bu XPhos (L2), Ru-Phos (L3), Johnphos (L4) and DavePhos (L5). Ru-Phos (L3) ligand exhibited high impact on the hydroformylation of eugenol providing high selectivity (90%) of linear aldehyde as major product. In addition, internal natural olefins like anethole and prenol provided moderate to high selectivity (65% and 85% respectively) of branched aldehydes as a major products. The various reaction parameters such as influence of ligands, P/Rh ratio, syngas pressure, temperature, time and solvents have been studied. A high activity and selectivity gained on the way to the linear aldehydes it may be due to the bulky, steric cyclohexyl and isopropoxy groups present in L3 phosphine ligand. Moreover, this catalytic system was smoothly converting natural olefins into corresponding linear and branched aldehydes with higher selectivity under the mild reaction conditions.