54631-81-1

Basic information

• Product Name: BOC-HYP(BZL)-OH
• Synonyms: (4R)-1-Boc-4-(phenylmethoxy)-L-proline;Boc-Hyp(Bzl)-OH >=98.0% (HPLC);Boc-O-benzyl-L-trans-4-hydroxyproline≥ 98% (HPLC);Boc-L-Hyp(Bzl)-OH·DCHA;Boc-O-benzyl-L-trans-4-hydroxyproline dicyclohexylammonium salt99%;T-BUTYLOXYCARBONYL-O-BENZYL-L-HYDROXYPROLINE;N-ALPHA-T-BUTOXYCARBONYL-O-BENZYL-L-HYDROXYPROLINE;N-ALPHA-T-BUTOXYCARBONYL-O-BENZYL-TRANS-4-HYDROXY-L-PROLINE
• CAS NO: 54631-81-1
• Molecular Formula: C₁₇H₂₃NO₅
• Molecular Weight: 321.37
• Product Categories: Amino Acid Derivatives;Amino Acids;Hydroxyproline [Hyp];Unusual Amino Acids;Boc-Amino acid series
• Mol File: 54631-81-1.mol
• Article Data: 17

Chemical Properties

• Melting Point: ~70 °C
• Boiling Point: 461.342 °C at 760 mmHg
• Flash Point: 232.812 °C
• Appearance: /
• Density: 1.22 g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.557
• Storage Temp.: Store at 0°C
• PKA: 3.75±0.40(Predicted)
• BRN: 5296858
• CAS DataBase Reference: BOC-HYP(BZL)-OH(CAS DataBase Reference)
• NIST Chemistry Reference: BOC-HYP(BZL)-OH(54631-81-1)
• EPA Substance Registry System: BOC-HYP(BZL)-OH(54631-81-1)

Safety Data

• WGK Germany: 3
• Hazardous Substances Data: 54631-81-1(Hazardous Substances Data)

Usage

Chemical Properties

White to off-white powder

Uses

Boc-Hyp(Bzl)-OH, is an amino acid building block used in peptide synthesis. With a growing peptide drug market the fast, reliable synthesis of peptides is of great importance.

InChI:InChI=1/C17H23NO5/c1-17(2,3)23-16(21)18-10-13(9-14(18)15(19)20)22-11-12-7-5-4-6-8-12/h4-8,13-14H,9-11H2,1-3H3,(H,19,20)/t13-,14+/m1/s1

Upstream product

• 1194032-60-4 (R)-4-benzyloxy-pyrrolidine-1,2-dicarboxylic acid 1-tert-butyl ester 
• 74-88-4 methyl iodide 
• 24424-99-5 di-tert-butyl dicarbonate 
• 1499-56-5 (R)-4-hydroxy-L-proline ethyl ester 
• 51-35-4 4R-4-hydroxyproline 
• 34619-03-9 tert-butyldicarbonate 
• 136024-60-7 1-(tert-butyl) 2-methyl (2S,4R)-4-(benzyloxy)pyrrolidine-1,2-dicarboxylate 
• 100-39-0 benzyl bromide 
• 74844-91-0 1-tert-butyl 2-methyl (2S,4R)-4-hydroxy-1,2-pyrrolidinedicarboxylate 
• 13726-69-7 (2S,4R)-4-hydroxy-1-[(2-methylpropan-2-yl)oxycarbonyl]pyrrolidine-2-carboxylic acid 
• 74844-91-0 (2S,4S)-N-tert-butoxycarbonyl-4-hydroxyproline methyl ester 
• 1332341-02-2 benzyl (2S)-2-Boc-amino-3-(2-oxiranyl)propionate 
• 87250-97-3 2’-methyl-2’-propanyl (1S,4S)-3-oxo-2-oxa-5-azabicyclo[2.2.1]heptane-5-carboxylate 
• 87691-27-8 N-tert-butoxycarbonyl-L-cis-4-hydroxyproline 

Downstream Products

• 81771-37-1 Gly-Pro-Hyp-Gly-Ala-Gly 
• 66831-16-1 O-benzyl-trans-4-hydroxy-L-proline hydrochloride 
• 868759-45-9 (2S,4R)-tert-butyl 4-(benzyloxy)-2-(methylsulfonylcarbamoyl)pyrrolidine-1-carboxylate 
• 902770-73-4 ethyl [1-[(4R)-benzyloxy-1-(tert-butoxycarbonyl)-(2S)-pyrrolidinylcarbonyl]-4-piperidinyl]acetate 
• 1238376-61-8 2-[(N-tert-butoxycarbonyl-4(R)-benzyloxy)-L-prolyl]1,2,3,4-tetrahydro-9H-pyrido[3,4-b ]indole 
• 1092844-45-5 (4R)-BOC-4-benzyloxyproline-N,N-dimethylamide 
• 1232834-99-9 (4R)-benzyloxy-(2S)-(N-methoxy-N-methylcarbamoyl)pyrrolidine-1-carboxylic acid tert-butyl ester 
• 1403945-55-0 (2S,4R)-tert-butyl 4-(benzyloxy)-2-(3-bromo-2-(3,5-difluorophenylcarbamoyl)-1H-pyrrol-1-ylcarbamoyl)pyrrolidine-1-carboxylate 
• 810673-97-3 Boc-Pro-Hyp(Bzl)-OFm 
• 47747-76-2 Boc-Pro-Hyp(Bzl)-Gly-OH 
• 810673-99-5 Boc-Pro-Hyp(Bzl)-Gly-OMe 
• 810673-98-4 Boc-Pro-Hyp(Bzl)-OH 
• 810673-96-2 H-Hyp(Bzl)-OFm 
• 886447-81-0 ethyl [4-[(4R)-benzyloxy-1-tert-butoxycarbonyl-(2S)-pyrrolidinylcarbonyl]-1-piperazinyl]acetate 

Relevant articles and documents

DNA POLYMERASE THETA INHIBITORS

The invention relates to heterocyclic derivatives and their use in the treatment and prophylaxis of cancer, and to compositions containing said derivatives and processes for their preparation.

HYDROXYPYRROLIDINE-SUBSTITUTED ARYLSULFONAMIDE COMPOUNDS WITH SELECTIVE ACTIVITY IN VOLTAGE-GATED SODIUM CHANNELS

Disclosed are compounds of Formula A, or a salt thereof: (A) Wherein "A1", R1, R2, R3, R6, and R7 are as defined herein, which compounds have properties for blocking Nav 1.7 ion channels fo

N-methyl-D-aspartate receptor modulators and methods of making and using same

Disclosed are compounds having enhanced potency in the modulation of NMDA receptor activity. Such compounds are contemplated for use in the treatment of diseases and disorders, such as learning, cognitive activities, and analgesia, particularly in alleviating and/or reducing neuropathic pain. Orally available formulations and other pharmaceutically acceptable delivery forms of the compounds, including intravenous formulations, are also disclosed.