5464-72-2

Usage

InChI:InChI=1/C12H24O3/c1-4-6-7-8-9-12(3,14)10-11(13)15-5-2/h14H,4-10H2,1-3H3

Upstream product

• 111-13-7 hexyl-methyl-ketone 
• 623-48-3 ethyl iodoacetae 
• 105-39-5 chloroacetic acid ethyl ester 
• 105-36-2 ethyl bromoacetate 
• 141-78-6 ethyl acetate 
• 73303-68-1 1-ethoxy-1-(triethylsiloxy)ethylene 

Downstream Products

• 5350-11-8 ethyl 3-methylnon-2-enoate 
• 35205-76-6 3-methyl-non-2-enoic acid 
• 35205-77-7 3-methyl-non-3-enoic acid 
• 91342-02-8 3-methyl-1-bromononane 
• 35205-79-9 3-methylnonanoic acid 
• 97030-00-7 5-methyl-undecanoic acid 
• 68329-37-3 1-(toluene-p-sulphonyloxy)-3-methylnonan-3-ol 

Relevant academic research and scientific papers

New application of bromotrimethylsilane: Elaboration of aldehydes/ketones into homologous α,β-unsaturated esters via β-hydroxy esters

α,β-Unsaturated esters are formed when β-hydroxy esters react with bromotrimethylsilane which is generated from chlorotrimethylsilane- lithium bromide in acetonitrile. Copyright Taylor & Francis, Inc.

Convenient preparation of metals deposited on solid supports and their use in organic synthesis

'High-surface alkali metals' can be conveniently prepared via deposition of corresponding metals on various supports such as sodium chloride, polyethylene, polypropylene and cross-linked polystyrene from their solutions in liquid ammonia. Alkali metals deposited on polymeric supports can be stored in form of stable suspensions in inert solvents and used for the acyloin and Dieckmann condensations and for preparation of organolithiums. Addition of the suspension of supported alkali metal to a solution of zinc chloride gave an active zinc on polymeric support, which can be used for the Reformatski and Barbier reactions.

ACTIVATION OF KETENE SILYL ACETALS BY 10-METHYLACRIDINIUM PERCHLORATE: A NOVEL CATALYSIS IN MUKAIYAMA REACTION

10-Methylacridinium perchlorate (1) effectively promotes various reactions of ketene silyl acetals: aldol and Michael addition products are obtained with aldehydes, ketones, acetals, and α-enones.The reactions exhibit unusual dependency upon 1, namely the yields are excellent when a catalytic amount of 1 is employed whereas no desired products are accessible by the use of 1 in a stoichiometric quantity.A novel catalytic cycle is proposed.

The Synthesis of 8,10,12-Triazaprostaglandin Analogues: 1,2,4-Triazolidine-3,5-dione Derivatives

In the search for active, more selective prostaglandin analogues, the synthesis of 8,10,12-triazaprostaglandin analogues has been achieved from readily available 4-methyl-1,2,4-triazolidine-3,5-dione.The general approach involved introduction of the α- and ω-side-chain as entire units by step-wise N-alkylation.The problems encountered with this approach of competing N- and O-mono- and di-alkylation were overcome, eventually, such that judicious choice of the initial mono-N-alkylation step enabled the synthesis of analogues incorporating wide variations in the α- and ω-side-chain.Important structural modifications included introduction of unsaturation into the α-side-chain at the 5,6-position and of methyl groups into the ω-side-chain at the 15- and 16-position as exemplified by the synthesis of 1--2-(3-hydroxy-3,4-dimethyloctyl)-4-methyl-1,2,4-triazolidine-3,5-dione (19).The stable triazaprostaglandin analogues were synthesized as racemic compounds but, nevertheless, compound (19) possessed bronchodilator activity of a similar order to that of the natural prostaglandins PGE1 and PGE2.

1,2-Disubstituted oxo triazolidine

Compounds of the formula (I): STR1 wherein n is 3 to 5; Y is --CH2 --CH2, --CH=CH-- or C C--; L is O or S; R1 is C1-4 alkyl; R2 is hydrogen, C1-4 alkyl or phenyl; R3 is hydroxy o

Cyclic exo amides

Compounds of formula (I): STR1 wherein: M IS 0 OR 1; n is 4 to 8; X is CO, protected CO, CROH in which R is hydrogen or C1-4 alkyl and in which the OH moiety may be protected; R1 is hydrogen, or CO2 R1 represents an ester group in Which the R1 moiety contains 1 to 12 carbon atoms; R3 is hydroxy or protected hydroxy; R2 and R4 are separately hydrogen, C1-9 alkyl, C5-8 cycloalkyl, C5-8 cycloalkyl-C1-6 alkyl, phenyl, phenyl C1-6 alkyl, naphthyl, naphthyl C1-6 alkyl, any of which phenyl or naphthyl moieties may be substituted by one or more halogen, trifluoromethyl, C1-6 alkyl, C1-6 alkoxy or nitro groups, or R2 and R4 taken with the carbon atom to which they are joined represent C5-8 cycloalkyl; R5 is hydrogen, C1-4 alkyl or phenyl; and salts thereof; have useful pharmacological properties including anti-gastric secretion, bronchodilator and platelet aggregation inhibition activities.