54641-27-9

Usage

Uses

Used in Polymer Synthesis:
N-(2-Aminoethyl)acrylamide hydrochloride is used as a monomer in the synthesis of polymers for various applications due to its reactive acrylamide group, which can be polymerized to form polymers with specific properties.
Used in Biochemical Assays:
As a reagent in biochemical assays, N-(2-Aminoethyl)acrylamide hydrochloride is utilized for its ability to interact with biomolecules, facilitating the study of biological processes and the development of diagnostic tools.
Used in Pharmaceutical and Cosmetic Production:
N-(2-Aminoethyl)acrylamide hydrochloride is used as an active ingredient or a component in the formulation of pharmaceuticals and cosmetics, leveraging its potential therapeutic and cosmetic properties.
Used in Protein and Peptide Modification:
In research, N-(2-Aminoethyl)acrylamide hydrochloride is employed for the modification of proteins and peptides, enabling the exploration of their structure, function, and interactions with other biomolecules.
Used in Medical and Pharmaceutical Research:
N-(2-Aminoethyl)acrylamide hydrochloride is used as a subject of interest in medical and pharmaceutical research for its potential anti-inflammatory and anti-cancer properties, with ongoing investigations to explore its therapeutic potential in treating various diseases and conditions.
Used in Anti-Inflammatory Applications:
N-(2-Aminoethyl)acrylamide hydrochloride is used as an anti-inflammatory agent for its potential to modulate inflammatory processes, offering a promising avenue for the development of new treatments for inflammatory diseases.
Used in Anticancer Applications:
N-(2-Aminoethyl)acrylamide hydrochloride is used as a potential anticancer agent, with research focusing on its ability to target and inhibit cancer cell growth and proliferation, as well as its potential to enhance the efficacy of existing cancer therapies.

Upstream product

• 165196-44-1 tert-butyl (2-acrylamidoethyl)carbamate 
• 107-15-3 ethylenediamine 
• 814-68-6 acryloyl chloride 

Downstream Products

• 23918-29-8 N-[beta-aminoethyl]acrylamide 

Relevant academic research and scientific papers

POLYMER OF GAMMA-GLUTAMYL TRANSPEPTIDASE CATALYZING HYDROLYSIS-INDUCED CHARGE REVERSAL AND ITS APPLICATION IN THE FIELD OF DRUG DELIVERY

This present invention relates to a polymer of γ-glutamyl transpeptidase catalyzing hydrolysis-induced charge reversal. The polymer comprises a γ-glutamyl transpeptidase-responsive element represented by Formula (I). When the polymer is used as drug carrier for anticancer drug, it can have a long circulation time in the blood, and can realize a charge reversal from negatively charged or the neutral to positively charged around the tumor blood vessel region, so that the positively charged polymer effectively penetrates deep into the tumor tissue, fast entering into the tumor cells, and greatly improves the therapeutic effect of the drug on the tumor. This overcomes the problems of slow diffusion of traditional polymer drug carriers in tumors and weak interaction with tumor cells, and has great significance in the field of anticancer treatment in the medical field.

COMPOUNDS USEFUL AS IMMUNOMODULATORS

The present disclosure generally relates to compounds useful as immunomodulators. Provided herein are compounds, compositions comprising such compounds, and methods of their use. The disclosure further pertains to pharmaceutical compositions comprising at least one compound according to the disclosure that are useful for the treatment of various diseases, including cancer and infectious diseases.

Synthesis of pyridine acrylates and acrylamides and their corresponding pyridinium ions as versatile cross-linkers for tunable hydrogels

A small library of cross-linkers for hydrogels was synthesized. The cross-linkers consisted of 2,6- and 3,5-diacylpyridine or 2,4,6-triacylpyridine as the core unit, which were tethered via ethylene glycol, amino ethanol, and 1,n-diamine spacers to terminal acrylate or acrylamide moieties. Esterification and amide formation of the terminal acryl units were found to be dependent on the ratio of NH/O in the spacer, the constitution pattern of the pyridine ring, and the total number of acryl groups. Thus, esters generally gave higher yields than amides decreasing with increasing number of NH in the spacer and with increasing number of acryl units. In the case of 3,5-diacylpyridine derivatives, these trends were less prominent as compared to the 2,6-diacylpyridine series, indicating that steric hindrance and unfavorable hydrogen bonding interaction of the spacers might influence the observed reactivity differences. The 3,5-diacylpyridines were converted to the N-methylpyridinium salts and selected members of both neutral and cationic 3,5-diacylpyridinium derivatives were submitted to hydrogelations with synthetic polymer poly(1-glycidylpiperazine) via aza-Michael addition and thiolated natural hyaluronan via thio-Michael reaction, respectively. Rheological properties of the resulting hydrogels were studied, revealing that both spacer type as well as charge affected elastic moduli and degree of swelling. Georg Thieme Verlag Stuttgart New York.

Conjugate addition versus cycloaddition/condensation of nitro compounds in water: Selectivity, acid-base catalysis, and induction period

Nitroacetates and nitroacetamides react in water as in chloroform with electron-deficient dipolarophiles to give condensation or conjugate addition products under base catalysis. In general, high selectivity towards condensation is observed in water, with