5456-23-5

Usage

Uses

Used in Pharmaceutical Research:
2-BROMODIETHYLACETIC ACID is utilized as an intermediate in organic synthesis and pharmaceutical research for its potential to contribute to the development of new drugs. Its anti-inflammatory and analgesic effects make it a valuable component in the creation of medications aimed at treating pain and inflammation.
Used in Organic Synthesis:
In the realm of organic synthesis, 2-BROMODIETHYLACETIC ACID serves as a reagent, facilitating the synthesis of a variety of organic compounds. Its structural properties allow it to act as a key building block, contributing to the formation of complex molecules in chemical reactions.
Used in Chemical Industry:
The chemical industry leverages 2-BROMODIETHYLACETIC ACID as an important component in the production of various chemical products. Its versatility and reactivity make it a valuable asset in the synthesis of a range of compounds used across different sectors.

InChI:InChI=1/C6H11BrO2/c1-3-6(7,4-2)5(8)9/h3-4H2,1-2H3,(H,8,9)

Upstream product

• 510-20-3 diethyl malonic acid 
• 7726-95-6 bromine 
• 88-09-5 2-Ethylbutanoic acid 

Downstream Products

• 6937-28-6 ethyl 2-bromo-2-ethylbutanoate 
• 40239-61-0 2,2,4-trimethylhexan-3-one 
• 92036-40-3 α-Benzylmercapto-α-ethyl-buttersaeure 
• 80784-36-7 2-Ethyl-2-(2-methoxy-phenoxy)-butyric acid 
• 69379-34-6 2-ethyl-3-methyl-1-indanone 
• 69379-35-7 2-bromo-2-ethyl-1-phenylbutan-1-one 
• 3639-21-2 2-ethyl-2-hydroxybutyric acid 
• 10035-10-6 hydrogen bromide 
• 103029-53-4 2,2-diethyl-4-methyl-thiomorpholin-3-one 
• 108489-28-7 2-ethyl-2-(β-amino-isobutylsulfanyl)-butyric acid ethyl ester 
• 91426-73-2 2-ethyl-2-(2-amino-ethylsulfanyl)-butyric acid ethyl ester 
• 67431-23-6 2-ethyl-2-mercapto-butyric acid ethyl ester 
• 69226-23-9 2,2,5-triethyl-thiomorpholin-3-one 
• 69226-08-0 2,2-diethyl-5,5-dimethyl-thiomorpholin-3-one 

Relevant academic research and scientific papers

2-Amino-1,3-thiazol-4(5H)-ones as potent and selective 11β- hydroxysteroid dehydrogenase type 1 inhibitors: Enzyme-ligand co-crystal structure and demonstration of pharmacodynamic effects in C57Bl/6 mice

11β-Hydroxysteroid dehydrogenase type 1 (11β-HSD1) has attracted considerable attention during the past few years as a potential target for the treatment of diseases associated with metabolic syndrome. In our ongoing work on 11β-HSD1 inhibitors, a series of new 2-amino-1,3-thiazol-4(5H)-ones were explored. By inserting various cycloalkylamines at the 2-position and alkyl groups or spirocycloalkyl groups at the 5-position of the thiazolone, several potent 11β-HSD1 inhibitors were identified. An X-ray cocrystal structure of human 11β-HSD1 with compound 6d (Ki = 28 nM) revealed a large lipophilic pocket accessible by substitution off the 2-position of the thiazolone. To increase potency, analogues were prepared with larger lipophilic groups at this position. One of these compounds, the 3-noradamantyl analogue 8b, was a potent inhibitor of human 11β-HSD1 (Ki = 3 nM) and also inhibited 11β-HSD1 activity in lean C57Bl/6 mice when evaluated in an ex vivo adipose and liver cortisone to cortisol conversion assay.