54660-08-1

Basic information

• Product Name: 1-(4-FLUOROPHENYL)-2-PYRROLIDINONE
• Synonyms: BUTTPARK 32\07-63;1-(4-FLUOROPHENYL)-2-PYRROLIDINONE;1-(4-Fluorophenyl)-2-pyrrolidone 97%;1-(4-Fluorophenyl)-2-pyrrolidone97%;1-(4-Fluorophenyl)pyrrolidin-2-one;1-(4-FLUOROPHENYL)-2-PYRROLIDINONE 99+%;1-(4-Fluorophenyl)-2-oxopyrrolidine, 1-Fluoro-4-(2-oxopyrrolidin-1-yl)benzene;1-(4-Fluorophenyl)pyrrolidin-2-one 97%
• CAS NO: 54660-08-1
• Molecular Formula: C₁₀H₁₀FNO
• Molecular Weight: 179.19
• Product Categories: Halides;Phenyls & Phenyl-Het
• Mol File: 54660-08-1.mol
• Article Data: 9

Chemical Properties

• Melting Point: 55-58 °C
• Boiling Point: 375.1 °C at 760 mmHg
• Flash Point: 180.6 °C
• Appearance: beige crystalline powder
• Density: 1.1545 (estimate)
• Vapor Pressure: 7.99E-06mmHg at 25°C
• Refractive Index: 1.557
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 1-(4-FLUOROPHENYL)-2-PYRROLIDINONE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(4-FLUOROPHENYL)-2-PYRROLIDINONE(54660-08-1)
• EPA Substance Registry System: 1-(4-FLUOROPHENYL)-2-PYRROLIDINONE(54660-08-1)

Safety Data

• Hazard Codes: Xi,Xn
• Statements: 22
• Safety Statements: 24/25
• Hazardous Substances Data: 54660-08-1(Hazardous Substances Data)

Usage

Chemical Properties

beige crystalline powder

InChI:InChI=1/C10H10FNO/c11-8-3-5-9(6-4-8)12-7-1-2-10(12)13/h3-6H,1-2,7H2

Upstream product

• 616-45-5 2-pyrrolidinon 
• 352-34-1 4-fluoro-1-iodobenzene 
• 460-00-4 1-Bromo-4-fluorobenzene 
• 1765-93-1 4-fluoroboronic acid 
• 4280-36-8 (4-fluorophenyl)piperidine 
• 110-63-4 Butane-1,4-diol 
• 371-40-4 4-fluoroaniline 

Downstream Products

• 1062574-82-6 [1-(4-fluoro-phenyl)-2-oxo-pyrrolidin-3-yl]-phosphonic acid diethyl ester 
• 4280-34-6 N-(4-fluorophenyl)tetrahydropyrrole 
• 852227-90-8 1-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)pyrrolidineate 

Relevant articles and documents

Synthetic method of N - aryl substituted lactam compound

The invention discloses a method. NSynthesis method of - aryl substituted lactam compound, and synthesis method thereof is promoted by tertiary butyl hydroperoxide and-tert-butyl hydroperoxideNMulti-step series reaction synthesis - aryl substituted saturated cyclic amine compoundN- Aryl substituted lactam compounds are simple and convenient to operate. The method has the advantages of no transition metal catalysis, wide substrate application range and the like, and is suitable for industrial production.

Selective synthesis of pyrrolidin-2-ones and 3-iodopyrroles: Via the ring contraction and deformylative functionalization of piperidine derivatives

In this paper, a selective synthesis of pyrrolidin-2-ones and 3-iodopyrroles via the cascade reactions of N-substituted piperidines is presented. Mechanistically, the formation of pyrrolidin-2-ones involves a domino process including the in situ formation of pyrrolidine-2-carbaldehyde followed by carboxylic acid formation, decarboxylation and ipso-oxidation. On the other hand, 3-iodopyrroles are believed to be formed via the initial generation of pyrrolidine-2-carbaldehyde followed by carboxylic acid formation, decarboxylation, dehydrogenation, iodination and aromatization. Interestingly, either pyrrolidin-2-ones or 3-iodopyrroles could be obtained selectively from the same substrates, and the selectivity was easily tuned by using a specific oxidant and additive.

Aluminium Chloride-Mediated Synthesis of 1-Chloro-2,2,2-Trifluoroethylidene-Substituted Pyrrolidones

An aluminium chloride-mediated cascade reaction between pyrrolidones and trifluoroacetic anhydride is reported. Functionally diverse 1-chloro-2,2,2-trifluoroethylidene-substituted pyrrolidones were obtained in moderate to high yields through electrophilic trifluoroacetylation, nucleophilic chlorination, and elimination. This procedure has a wide scope, good functional-group tolerance and the reaction conditions are amenable to scale up. Additionally the obtained 1-chloro-2,2,2-trifluoroethylidene products can be applied to further functionalization as trifluoromethyl-containing building blocks. Some of the title compounds showed fungicidal activity against cucumber downy mildew (CDM). (Figure presented.).