5467-20-9Relevant academic research and scientific papers
Computationally Aided Absolute Stereochemical Determination of Enantioenriched Amines
Zhang, Jun,Gholami, Hadi,Ding, Xinliang,Chun, Minji,Vasileiou, Chrysoula,Nehira, Tatsuo,Borhan, Babak
supporting information, p. 1362 - 1365 (2017/03/23)
A simple and efficient protocol for sensing the absolute stereochemistry and enantiomeric excess of chiral monoamines is reported. Preparation of the sample requires a single-step reaction of the 1,1′-(bromomethylene)dinaphthalene (BDN) with the chiral amine. Analysis of the exciton coupled circular dichroism generated from the BDN-derivatized chiral amine sample, along with comparison to conformational analysis performed computationally, yields the absolute stereochemistry of the parent chiral monoamine.
Synthesis of chiral C1-symmetric N-heterocyclic carbene ligands: Application toward copper-catalyzed homocoupling of 2-naphthols
Holtz-Mulholland, Michael,Collins, Shawn K.
supporting information, p. 375 - 380 (2014/02/14)
Novel chiral C 1-symmetric NHC ligands can be prepared via dialkylation of chiral imidazoline scaffolds. Asymmetry in the ligand/metal complexes results from a chiral relay effect. The C 1-symmetric nature of the NHC ligand was proposed to allow for improved reactivity versus other achiral and chiral NHC complexes. The benefit of such ligands was demonstrated in copper-catalyzed oxidative coupling reactions. Georg Thieme Verlag KG Stuttgart · New York.
