54672-14-9

Usage

Uses

Used in Pharmaceutical Industry:
2-(Dimethylamino)benzotrifluoride serves as a crucial intermediate in the production of various pharmaceutical compounds. Its unique chemical structure allows for the synthesis of a wide range of medications, contributing to the development of new treatments and therapies.
Used in Agrochemical Industry:
In the agrochemical sector, 2-(Dimethylamino)benzotrifluoride is employed as an intermediate for the synthesis of various agrochemicals, including pesticides and herbicides. Its role in these applications helps to enhance crop protection and contribute to increased agricultural productivity.
Used as a Chemical Intermediate:
2-(Dimethylamino)benzotrifluoride is used as a chemical intermediate for the synthesis of other organic compounds in various chemical processes. Its reactivity and functional groups make it a valuable building block in the creation of specialty chemicals and materials.

Upstream product

• 54672-13-8 4-bromo-N,N-dimethyl-2-(trifluoromethyl)-aniline 
• 75-63-8 Bromotrifluoromethane 
• 121-69-7 N,N-dimethyl-aniline 
• 1092380-21-6 S-(trifluoromethyl)-4-nitrophenylphenylsulfonium tetrafluoroborate 
• 1226-46-6 thiomichlersketone 
• 1092380-24-9 S-(trifluoromethyl)-4-nitrophenylphenylsulfonium triflate 
• 81290-20-2 (trifluoromethyl)trimethylsilane 
• 64-18-6 formic acid 
• 14925-10-1 N-Methyl-2-(trifluoromethyl)aniline 
• 1622092-08-3 2,4-dimethyl-7-(pentafluorosulfanyl)-5-(trifluoromethyl)dibenzo[b,d]thiophenium trifluoromethanesulfonate 
• 124-38-9 carbon dioxide 
• 54672-09-2 2-dimethylamino-5-nitrobenzotrifluoride 
• 777-37-7 4-chloro-3-(trifluoromethyl)nitrobenzene 
• 54672-12-7 N₁,N₁-dimethyl-2-(trifluoromethyl)benzene-1,4-diamine 

Relevant academic research and scientific papers

The 2,4-dimethyl-7-pentafluorosulfanyl-5-(trifluoromethyl)dibenzo[b,d] thiophenium trifluoromethanesulfonate: The SF5-analog of Umemoto salt

The SF5-analog of the Umemoto salt was synthesized in just two steps by combining our recently reported SF5-biaryl synthesis, via Suzuki coupling with 4-(pentafluorosulfanyl)benzenediazonium tetrafluoroborate, with Magnier's one-pot synthesis of dibenzothiophenium salts employing CF 3SO2Na and triflic anhydride. The trifluoromethylating power of this novel onium salt toward reactive arenes was tested in a survey study on small scale.

General catalytic methylation of amines with formic acid under mild reaction conditions

A general catalytic protocol for the methylation of amines has been developed applying, for the first time, formic acid as the C1 building block and silanes as reducing agents. A broad range of aromatic and aliphatic, both primary and secondary, amines has been converted to the corresponding tertiary amines including [N-13C]-labelled drugs in good to excellent yields under mild conditions. Methylation made easy: A general catalytic protocol for the methylation of amines has been developed applying, for the first time, formic acid as the C1 building block and silanes as reducing agents. A broad range of aromatic and aliphatic, both primary and secondary, amines has been converted to the corresponding tertiary amines, including [N-13C]-labelled drugs, in good to excellent yields at mild conditions (see scheme; dppp=(1,3-bis(diphenylphosphino)propane)).

A general catalytic methylation of amines using carbon dioxide

Putting CO2 to work: Carbon dioxide is shown to be a general and selective methylating reagent for secondary and primary, aromatic and aliphatic amines under reductive conditions. A variety of tertiary amines are obtained from CO2 and commercially available silanes in high yields with good tolerance to nitrile, olefin, ether, ester, and hydroxy groups. Copyright

Silver-catalysed trifluoromethylation of arenes at room temperature

A variety of heteroarenes and electron rich arenes can be trifluoromethylated at room temperature with TMSCF3, catalytic silver and PhI(OAc)2.

A new method for the synthesis of trifluoromethylating agents-Diaryltrifluoromethylsulfonium salts

A new synthetic method has been developed to prepare diaryltrifluoromethylsulfonium salts from diaryldifluorosulfuranes by the action of Me3SiCF3/F-. This reaction is the transformation of nucleophilic trifluoro-methylating reagent into electrophilic one.

TRIFLUOROMETHYLATION OF AROMATIC AMINO AND THIO COMPOUNDS BY BISTRIFLUOROMETHYL TELLURIDE

The reaction of aromatic and heterocyclic amines with (CF3)2Te gave the products from trifluoromethylation in the aromatic ring.The reaction with the corresponding thiols gave S-trifluoromethyl derivatives.

Photochemical Trifluoromethylation of Some Aromatic and Heteroaromatic Compounds with Trifluoromethyl Bromide

The photochemical introduction of trifluoromethyl group with CF3Br in aromatic and heteroaromatic rings was investigated for 9 compounds.Naphthalene, anthracene, anisole, N,N-dimethylaniline, ferrocene, benzothiophene, isoquinoline, and N-methylpyrrole gave trifluoromethylated products in 6.5-100percent yields.In one step from uracil, a pharmacologically important 5-trifluoromethyluracil can be synthesized by this method in 11percent yield.Based on the mechanistic study carried out for the naphthalene-CF3Br-CH3CN system, the reaction is found to proceed via the electron transfer from an excited singlet state of naphthalene to CF3Br.