54725-17-6

Basic information

• Product Name: 1-Phenyl-2-heptyne
• Synonyms: 1-Phenyl-2-heptyne;2-Heptynylbenzene
• CAS NO: 54725-17-6
• Molecular Formula: C₁₃H₁₆
• Molecular Weight: 172.27
• Mol File: 54725-17-6.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1-Phenyl-2-heptyne(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Phenyl-2-heptyne(54725-17-6)
• EPA Substance Registry System: 1-Phenyl-2-heptyne(54725-17-6)

Safety Data

• Hazardous Substances Data: 54725-17-6(Hazardous Substances Data)

Upstream product

• 1002-36-4 hep-2-yn-1-ol 
• 73922-80-2 1-phenylhept-2-yn-1-ol 
• 260783-80-0 N,N,N--trimethyl--1--phenylmethanaminium trifluoromethanesulfonate 
• 693-02-7 hex-1-yne 
• 100-39-0 benzyl bromide 
• 28687-98-1 diethyl(1-hexynyl)aluminum 
• 1220698-75-8 1-phenyl-2-heptynyl formate 
• 81927-55-1 O-benzyl 2,2,2-trichloroacetimidate 
• 71-43-2 benzene 
• 32359-01-6 hexenylmagnesium bromide 
• 100-44-7 benzyl chloride 
• 122-56-5 tributyl borane 
• 16169-88-3 1-phenylprop-2-ynyl acetate 

Downstream Products

• 54725-18-7 Z-1-phenyl-2-heptene 
• 26447-63-2 1-phenyl-2-heptene 

Relevant articles and documents

Palladium-Catalyzed Coupling of Terminal Alkynes with Benzyl Ammonium Salts

A highly efficient palladium-catalyzed Sonogashira coupling of benzylic ammonium salts with terminal alkynes is developed. This strategy provides a facile access to a series of internal alkyne derivatives in moderate to excellent yields via C-N bond cleavage and C(sp3)-C(sp) bond formation. The broad substrate scope and high functional group tolerance make this reaction attractive for organic synthesis.

Simple and efficient nickel-catalyzed cross-coupling reaction of alkynylalanes with benzylic and aryl bromides

Highly efficient and simple coupling reactions of benzylic and aryl bromides with aluminium acetylide catalyzed by NiCl2(PPh 3)2 are reported. The coupling reactions proceed at room temperature employing 4 mol% catalyst, affording coupling products in excellent yields of up to 95% in short reaction times. The system worked efficiently with aryl and heterocyclic bromides as well.

Selective synthesis of allenes and alkynes through ligand-controlled, palladium-catalyzed decarboxylative hydrogenolysis of propargylic formates

Ligand-controlled regioselective palladium-catalyzed decarboxylative hydrogenolysis of propargylic formates is described. A wide range of allenes and alkynes were obtained by using either 1,2-diphenylphosphinoethane (DPPE) or 1,6-bisdiphenylphosphinohexane (DPPH) as a catalyst ligand.

Gold(I)-catalyzed arylmethylation of terminal alkynes

AuCl/AgOTf catalyzes the reaction of terminal alkynes with aryl trichloroacetimidate to afford arylmethylation products in moderate to good yields.

Gold(III)-catalyzed direct nucleophilic substitution of propargylic alcohols

Gold-catalyzed nucleophilic substitution of propargylic alcohols with various nucleophiles (allylsilane, electron-rich aromatics, alcohols, thiols, hydrides, 1,3-dicarbonyl derivatives, sulfonamides) is described under very mild conditions (room temperatu

Lewis acid catalyzed propargylation of arenes with O-propargyl trichloroacetimidates: Synthesis of 1,3-diarylpropynes

(Chemical Equation Presented) The BF3·OEt 2-catalyzed Friedel-Crafts propargylation of aromatic compounds with O-propargyl trichloroacetimidates is highly efficient and affords 1,3-diarylpropyne derivatives in good yields.

Cobalt-catalyzed benzyl-alkynyl coupling

Benzylic halides coupled with 1-alkynylmagnesium halides in the presence of a catalytic amount of Co(acac)3 to provide 1-aryl-2-alkynes in moderate to good yield.