54784-83-7Relevant articles and documents
Acid-catalyzed chirality-transferring intramolecular Friedel-Crafts cyclization of α-hydroxy-α-alkenylsilanes
Sakaguchi, Kazuhiko,Kubota, Shunnichi,Akagi, Wataru,Ikeda, Naoko,Higashino, Masato,Ariyoshi, Shoma,Shinada, Tetsuro,Ohfune, Yasufumi,Nishimura, Takahiro
, p. 8635 - 8638 (2019/07/25)
Acid-catalyzed intramolecular Friedel-Crafts cyclization of optically active α-hydroxy-α-alkenylsilanes possessing a benzene ring (>99% ee) with TMSOTf as a Lewis acid gave enantio-enriched tetrahydronaphthalenes (up to 98% ee). The silyl group attached to the chiral carbon played a crucial role in the chirality transfer.
Tunable P-Chiral Bisdihydrobenzooxaphosphole Ligands for Enantioselective Hydroformylation
Tan, Renchang,Zheng, Xin,Qu, Bo,Sader, C. Avery,Fandrick, Keith R.,Senanayake, Chris H.,Zhang, Xumu
supporting information, p. 3346 - 3349 (2016/07/26)
Air-stable and tunable chiral bisdihydrobenzooxaphosphole ligands (BIBOPs) were employed in rhodium-catalyzed asymmetric hydroformylation of various terminal olefins with excellent conversions (>99%), moderate-to-excellent enantioselectivities (up to 95:5 er), and branched to linear ratios (b:l) of up to 400.
Removal of human ether-à-go-go related gene (hERG) K+ channel affinity through rigidity: A case of clofilium analogues
Louvel, Julien,Carvalho, Jo?o F.S.,Yu, Zhiyi,Soethoudt, Marjolein,Lenselink, Eelke B.,Klaasse, Elisabeth,Brussee, Johannes,Ijzerman, Adriaan P.
, p. 9427 - 9440 (2014/01/06)
Cardiotoxicity is a side effect that plagues modern drug design and is very often due to the off-target blockade of the human ether-à-go-go related gene (hERG) potassium channel. To better understand the structural determinants of this blockade, we design
