20637-04-1

Basic information

• Product Name: methyl 4-(4-chlorophenyl)butanoate
• Synonyms: methyl 4-(4-chlorophenyl)butanoate;4-Chlorobenzenebutanoic acid methyl ester;Benzenebutanoic acid, 4-chloro-, Methyl ester
• CAS NO: 20637-04-1
• Molecular Formula: C₁₁H₁₃ClO₂
• Molecular Weight: 212.67
• Mol File: 20637-04-1.mol

Chemical Properties

• Appearance: /
• Density: 1.136
• CAS DataBase Reference: methyl 4-(4-chlorophenyl)butanoate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl 4-(4-chlorophenyl)butanoate(20637-04-1)
• EPA Substance Registry System: methyl 4-(4-chlorophenyl)butanoate(20637-04-1)

Safety Data

• Hazardous Substances Data: 20637-04-1(Hazardous Substances Data)

Usage

Uses

Used in Flavoring and Fragrance Industry:
Methyl 4-(4-chlorophenyl)butanoate is used as a flavoring agent and fragrance ingredient for its distinctive pineapple-like aroma. It is incorporated into food products and cosmetics to enhance their sensory appeal.
Used in Pharmaceutical Synthesis:
In the pharmaceutical industry, methyl 4-(4-chlorophenyl)butanoate serves as an intermediate in the synthesis of various drugs. Its unique chemical structure contributes to the development of new medicinal compounds.
Used in Agrochemical Synthesis:
Similarly, in the agrochemical sector, this compound is used as an intermediate in the production of various agrochemicals, playing a role in the development of agricultural products.
Safety Precautions:
It is crucial to handle methyl 4-(4-chlorophenyl)butanoate with care due to its potential to cause skin and eye irritation. Proper storage and disposal methods are essential to minimize health and environmental risks.

Upstream product

• 67-56-1 methanol 
• 4619-18-5 4-(4-chlorophenyl)butanoic acid 
• 3984-34-7 4-(4-chlorophenyl)-4-oxobutanoic acid 
• 616-38-6 carbonic acid dimethyl ester 
• 1073-67-2 4-vinylbenzyl chloride 
• 2365-48-2 Methyl thioglycolate 
• 52372-80-2 (4-chlorobenzylidene)hydrazine 
• 292638-85-8 acrylic acid methyl ester 
• 104-88-1 4-chlorobenzaldehyde 
• 108-90-7 chlorobenzene 

Downstream Products

• 79098-18-3 5-<3-(4-Chlorphenyl)propyl>-2,8-dimethyl-5-nonanol 
• 210346-60-4 4-(4-Chloro-2-nitro-phenyl)-butyric acid methyl ester 
• 210346-26-2 4-(2-Acetylamino-4-chloro-phenyl)-butyric acid 
• 210346-61-5 4-(2-Acetylamino-4-chloro-phenyl)-butyric acid methyl ester 
• 79098-16-1 4-<7-Methyl-4-(3-methylbutyl)octyl>anilin 
• 79098-19-4 1-Chlor-4-<7-methyl-4-(3-methylbutyl)octyl>benzol 
• 79098-17-2 1-Chloro-4-[4-chloro-7-methyl-4-(3-methyl-butyl)-octyl]-benzene 
• 1227182-55-9 1,1-diphenyl-4-(4-chlorophenyl)butan-1-ol 
• 55010-15-6 2-methyl-5-(4-chlorophenyl)-2-pentanol 
• 54784-83-7 4-(4-chlorophenyl)butanal 

Relevant articles and documents

Copper-Catalyzed Conjugate Addition of Carbonyls as Carbanion Equivalent via Hydrazones

Copper-catalyzed conjugate addition is a classic method for forming new carbon-carbon bonds. However, copper has never showed catalytic activity for umpolung carbanions in hydrazone chemistry. Herein, we report a facile conjugate addition of hydrazone catalyzed by readily available copper complexes at room temperature. The employment of mesitylcopper(I) and electron-rich phosphine bidentate ligand is a key factor affecting reactivity. The reaction allows various aromatic hydrazones to react with diverse conjugated compounds to produce 1,4-adducts in yields of about 20 to 99%.

BEXAROTENE DERIVATIVES AND THEIR USE IN TREATING CANCER

This disclosure relates to compositions and methods for treating cancer. Specifically, this disclosure relates to bexarotene derivatives, methods for treating cancer, autoimmune disorders, and/or skin dermatitis, and/or methods for increasing peripheral blood counts and/or improving immune system function.

Reductive C-C Coupling by Desulfurizing Gold-Catalyzed Photoreactions

[Au2(μ-dppm)2]Cl2-mediated photocatalysis reactions are usually initiated by ultraviolet A (UVA) light; herein, an unreported system using blue light-emitting diodes (LEDs) as excitation light source was found. The red shift of the absorption wavelength originates from the combination of [Au2(μ-dppm)2]Cl2 and ligand (Ph3P or mercaptan). On the basis of this finding, a gold-catalyzed reductive desulfurizing C-C coupling of electrophilic radicals and styrenes mediated by blue LEDs is presented, a coupling which cannot be efficiently accessed by previously reported methods. This mild and highly efficient C-C bond formation strategy uses mercaptans both as electron-deficient alkyl radical precursor as well as the hydrogen source. Two examples of amino acids have also been modified by using this strategy. Moreover, this methodology could be applied in polymer synthesis. Gram-scale synthesis and mechanistic insights into this transformation are also presented.

A metal-free desulfurizing radical reductive C-C coupling of thiols and alkenes

An intermolecular reductive C-C coupling of electrophilic alkyl radicals and alkenes has been developed. Thiols were used as both hydrogen-donating reagents and alkyl radical precursors in the presence of triethyl phosphite and radical initiator. A wide range of alkenes, including styrenes, and aliphatic olefins were well tolerated in this transformation. Mechanistic studies indicated that a phosphite promoted radical desulfurization of thiols to access electrophilic alkyl radicals and a radical chain propagation process may be involved in this transformation.

Removal of human ether-à-go-go related gene (hERG) K+ channel affinity through rigidity: A case of clofilium analogues

Cardiotoxicity is a side effect that plagues modern drug design and is very often due to the off-target blockade of the human ether-à-go-go related gene (hERG) potassium channel. To better understand the structural determinants of this blockade, we design

Synthesis and antitumor activity of ring A- and F-modified hexacyclic camptothecin analogues

Nineteen ring A- and F-modified hexacyclic analogues of camptothecin were synthesized by Friedlander condensation of appropriately substituted bicyclic amino ketones with tricyclic ketone and were evaluated for cytotoxicity and topoisomerase I inhibitory