54837-93-3

Basic information

• Product Name: (4-methylphenyl)isobutylamine
• Synonyms: (4-methylphenyl)isobutylamine
• CAS NO: 54837-93-3
• Molecular Weight: 163.263
• Mol File: 54837-93-3.mol
• Article Data: 13

Chemical Properties

• CAS DataBase Reference: (4-methylphenyl)isobutylamine(CAS DataBase Reference)
• NIST Chemistry Reference: (4-methylphenyl)isobutylamine(54837-93-3)
• EPA Substance Registry System: (4-methylphenyl)isobutylamine(54837-93-3)

Safety Data

• Hazardous Substances Data: 54837-93-3(Hazardous Substances Data)

Upstream product

• 99-99-0 1-methyl-4-nitrobenzene 
• 78-84-2 isobutyraldehyde 
• 106-49-0 p-toluidine 
• 106-38-7 para-bromotoluene 
• 78-81-9 isobutylamine 
• 624-31-7 4-tolyl iodide 
• 78-82-0 Isobutyronitrile 
• 29540-83-8 p-tolyl triflate 
• 865-48-5 sodium t-butanolate 
• 106-43-4 para-chlorotoluene 
• 18169-42-1 [2-Methyl-prop-(E)-ylidene]-p-tolyl-amine 

Downstream Products

• 955-98-6 4,4'-Dimethyl-azoxybenzol 
• 67103-07-5 C₂₂H₂₄N₂O₄ 
• 860741-72-6 2-(N-isobutyl-p-toluidino)-1-phenyl-ethanone 

Relevant articles and documents

Catalytic Selective Oxidative Coupling of Secondary N-Alkylanilines: An Approach to Azoxyarene

Azoxyarenes are among important scaffolds in organic molecules. Direct oxidative coupling of primary anilines provides a concise fashion to construct them. However, whether these scaffolds can be prepared from secondary N-alkylanilines is not well explored. Here, we present a catalytic selective oxidative coupling of secondary N-alkylaniline to afford azoxyarene with tungsten catalyst under mild conditions. In addition, azoxy can be viewed as a bioisostere of alkene and amide. Several "azoxyarene analogues" of the corresponding bioactive alkenes and amides showed comparable promising anticancer activities.

INDAZOLE SULFONAMIDE DERIVATIVES AS INVERSE AGONISTS OF RETINOID-RELATED ORPHAN RECEPTOR GAMMA (ROR GAMMA (T))

Indazole sulfonamide derivatives of formula (I), the pharmaceutically acceptable addition salts thereof, the hydrates and/or solvates thereof, and the use of same as inverse agonists of retinoid-related orphan receptor gamma RORγt are described. Pharmaceutical compositions including such compounds, as well as the use thereof for the topical and/or oral treatment of RORγt receptor-mediated inflammatory diseases, in particular acne, psoriasis and/or atopic dermatitis are also described.

SULFONAMIDE COMPOUNDS AND THEIR USE IN THE MODULATION RETINOID - RELATED ORPHAN RECEPTOR

The present invention is directed to novel retinoid-related orphan receptor gamma (RORy) modulators of formula (I), processes for their preparation, pharmaceutical compositions containing these modulators, and their use in the treatment of inflammatory, metabolic and autoimmune diseases mediated by RORy wherein R1 to R7 are as defined in claim 1.