A convergent and straightforward synthetic method to prepare deaza-analogs of squalene epoxidase inhibitors

Article abstract of DOI:10.1080/00397919608005229

A general route to deaza-analogs of squalene epoxidase inhibitors of general formula A is described using a very convergent synthetic scheme illustrated by the preparation of compound 2b. A Heck reaction, and an enolate condensation with an appropriate electrophile are the key steps of the expedient elaboration of 2b or analogs.

Full text of DOI:10.1080/00397919608005229

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Synthetic Communications: An
International Journal for Rapid
Communication of Synthetic
Organic Chemistry
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A Convergent and
Straightforward Synthetic
Method to Prepare Deaza-
Analogs of Squalene Epoxidase
Inhibitors
Jean-Pierre Gotteland a , Marie-Christine Guilhem a
& Serge Halazy a
a Medicinal Chemistry Division , Centre de
Recherche Pierre FABRE , 17 Avenue Jean Moulin,
Castres, Cedex, 81106, France
Published online: 21 Aug 2006.
To cite this article: Jean-Pierre Gotteland , Marie-Christine Guilhem & Serge Halazy
(1996) A Convergent and Straightforward Synthetic Method to Prepare Deaza-Analogs
of Squalene Epoxidase Inhibitors, Synthetic Communications: An International Journal
for Rapid Communication of Synthetic Organic Chemistry, 26:15, 2925-2934, DOI:
10.1080/00397919608005229
To link to this article: http://dx.doi.org/10.1080/00397919608005229
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