Synthetic Communications p. 2925 - 2934 (1996)
Update date:2022-08-04
Topics:
Gotteland, Jean-Pierre
Guilhem, Marie-Christine
Halazy, Serge
A general route to deaza-analogs of squalene epoxidase inhibitors of general formula A is described using a very convergent synthetic scheme illustrated by the preparation of compound 2b. A Heck reaction, and an enolate condensation with an appropriate electrophile are the key steps of the expedient elaboration of 2b or analogs.
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