54879-93-5

Basic information

• Product Name: 1H-Indole, 7-methyl-2,3-diphenyl-
• CAS NO: 54879-93-5
• Molecular Formula: C21H17N
• Molecular Weight: 283.373
• Mol File: 54879-93-5.mol
• Article Data: 8

Chemical Properties

• CAS DataBase Reference: 1H-Indole, 7-methyl-2,3-diphenyl-(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Indole, 7-methyl-2,3-diphenyl-(54879-93-5)
• EPA Substance Registry System: 1H-Indole, 7-methyl-2,3-diphenyl-(54879-93-5)

Safety Data

• Hazardous Substances Data: 54879-93-5(Hazardous Substances Data)

Usage

Structure

Indole derivative with a methyl group at the 7th position and two phenyl groups attached to the 2nd and 3rd positions

Usage

Organic synthesis, pharmaceutical research, and analytical chemistry (due to its potential biological activities and fluorescent properties)

Properties

Unique structure and reactivity, making it a valuable building block for the synthesis of more complex organic molecules.

Upstream product

• 636-21-5 o-toluidine hydrochloride 
• 119-53-9 2-hydroxy-2-phenylacetophenone 
• 95-53-4 o-toluidine 
• 635-26-7 o-tolylhydrazine hydrochloride 
• 501-65-5 diphenyl acetylene 
• 380383-86-8 1-tert-butoxycarbonyl-2-(2-methylphenyl)hydrazine 
• 88-72-2 1-methyl-2-nitrobenzene 
• 1355058-39-7 7-methyl-2,3-diphenyl-1-(pyrimidin-2-yl)-1H-indole 
• 860699-97-4 optically inactive 2-hydroxy-2-(3-methyl-2-oxo-cyclohexyl)-1,2-diphenyl-ethanone 
• 1484-50-0 desyl bromide 
• 103973-40-6 deoxybenzoin o-tolylhydrazone 
• 5722-91-8 1,2-diphenyl-2-(phenylamino)ethanone 

Relevant articles and documents

Recyclable [Ru2Cl3(p-cymene)2][PF6]/Cu(OAc)2/PEG-400/H2O system for oxidative annulation of alkynes by aniline derivatives: Green synthesis of indoles

[Ru2Cl3(p-cymene)2][PF6] in a mixture of PEG-400 and water is shown to be a highly efficient catalyst for the oxidative annulation of alkynes by N-2-pyrimidyl-substituted anilines bearing a removable directing g

Rhodium(III)-Catalyzed Redox-Neutral C-H Annulation of Arylnitrones and Alkynes for the Synthesis of Indole Derivatives

By using a nitrone as the oxidizing directing group, a mild, practical and efficient rhodium(III)-catalyzed C-H functionalization for the synthesis of indole derivatives has been developed. This reaction obviates the need for an external oxidant and shows good functional group tolerance. The employment of a sterically hindered Mes group on the carbon center of the nitrone is crucial to produce indoles in high yield.

Regioselective synthesis of indoles via rhodium-catalyzed C-H activation directed by an in-situ generated redox-neutral group

A regioselective synthesis of indoles from arylhydrazine hydrochlorides with alkynes and diethyl ketone catalyzed by a rhodium complex is described. A possible mechanism involving an in-situ generated oxidizing directing group -N-Ni'CR1R2 assisted ortho-C-H activation and reductive elimination are proposed. The catalytic reaction is highly compatible with a wide range of functional arylhydrazines and alkynes. The reaction proceeds under mild reaction conditions and is atom-step economical.