54890-67-4

Upstream product

• 93-91-4 1-phenylbutan-1,3-dione 
• 50783-26-1 1-(2-methyl-2,3-dihydrobenzothiazol-2-yl)-methyl phenyl ketone 
• 54459-73-3 5-benzylidene-1,3-dimethyl-pyrimidine-2,4,6-trione 
• 769-42-6 1,3-dimethylbarbituric acid 
• 94-41-7 benzalacetophenone 
• 614-47-1 1,3-diphenyl-propen-3-one 

Downstream Products

• 54890-68-5 1,3-dimethyl-5,7-diphenyl-1,5-dihydro-pyrano[2,3-d]pyrimidine-2,4-dione 
• 59796-99-5 1,3-Dimethyl-5,7-diphenyl-pyrido<2,3-d>pyrimidin-2,4-(1H,3H)-dion 

Relevant academic research and scientific papers

Monoalkylated barbiturate derivatives: X-ray crystal structure, theoretical studies, and biological activities

Barbiturate derivatives are privileged structures with a broad range of pharmaceutical applications. We prepared a series of 5-monoalkylated barbiturate derivatives (3a–l) and evaluated, in?vitro, their antioxidant (DPPH assay), and α-glucosidase inhibito

Enantioselective organocatalytic Michael additions of: N, N ′-dialkylbarbituric acids to enones

N,N′-Dialkylbarbituric acids as cyclic malonamide donors were successfully used in the enantioselective Michael addition reaction of enones. Using cinchona alkaloid-based bifunctional squaramide as an organocatalyst, this Michael reaction of N,N′-di-tert-butylbarbituric acid with various enones features a highly enantioselective (91-99% ee) production of the corresponding optically active 5-substituted barbituric acid derivatives. The transformations of the Michael product for the barbituric acid structural unit were realized in two ways, deprotection to remove the N-tert-butyl group and alkylation to produce 5,5-disubstituted barbituric acid derivatives.

Benzothiazolines as radical transfer reagents: Hydroalkylation and hydroacylation of alkenes by radical generation under photoirradiation conditions

Novel radical transfer reagents under photoirradiation conditions were developed by the use of benzothiazoline derivatives. These reagents enabled both hydroalkylation and hydroacylation of alkenes under neutral conditions at ambient temperature without a

Synthesis of novel 5-monoalkylbarbiturate derivatives: New access to 1,2-oxazepines

A simple and straightforward route to 5-monoalkylbarbiturates by the NHEt2 catalyzed Michael reaction of 1,3-dimethylbarbituric acid and α,β-unsaturated ketones is described. Significantly, the reaction exclusively furnished 5-monoalkylbarbitur

Peculiar reaction behaviour of barbituric acid derivatives towards aromatic amines

5-Benzoylethyl barbituric acid derivatives 2a-c were prepared as useful precursors for the synthesis of pyrimidine fused heterocycles. Their behaviour as 1,5-diketocompounds towards aniline derivatives afforded the pyrimidoquinoline derivatives 6a-e. On t