549505-63-7

Upstream product

• 116332-54-8 4-fluoro-N-methoxy-N-methylbenzamide 
• 333-20-0 potassium thioacyanate 
• 457081-00-4 1-(4-fluorophenyl)-2-(2-fluoropyridin-4-yl)-2-(hydroxyimino)-ethan-1-one 
• 302839-09-4 1-(4-fluorophenyl)-2-(2-fluoropyridin-4-yl)ethan-1-one 
• 461-87-0 2-fluoro-4-methylpyridine 

Relevant academic research and scientific papers

2-THIO-SUBSTITUTED IMIDAZOLE DERIVATIVES AND THEIR USE IN PHARMACEUTICS

The invention relates to 2-thio-substituted imidazole derivatives of formula (I), wherein the radicals R1, R2, R3 and m have the meanings as cited in the description. The inventive compounds comprise an immunomodulatory action and/or an action that inhibits the release of cytokines and are thus suited for treating diseases associated with a disorder of the immune system.

Novel substituted pyridinyl imidazoles as potent anticytokine agents with low activity against hepatic cytochrome P450 enzymes

A series of polysubstituted pyridin-4-yl imidazole inhibitors of p38 MAP (mitogen-activated protein) kinase was prepared as small molecular anticytokine agents and drug candidates for the treatment of chronic inflammatory diseases. The contribution of sub