54963-39-2

Upstream product

• 2996-92-1 phenyl trimethylsiloxane 
• 16965-72-3 dimethyl α-diazobenzylphosphonate 
• 91-01-0 1,1-Diphenylmethanol 
• 121-45-9 phosphorous acid trimethyl ester 
• 98-80-6 phenylboronic acid 
• 591-50-4 iodobenzene 
• 756-79-6 dimethyl methane phosphonate 
• 776-74-9 Bromodiphenylmethane 
• 868-85-9 Dimethyl phosphite 
• 908093-98-1 diazodiphenylmethane 

Downstream Products

• 56982-84-4 1,1-diphenyl-2-(4-methylphenyl)ethylene 
• 18648-70-9 1,1-diphenyl-2-(4-nitrophenyl)ethene 
• 56982-86-6 1,1-Diphenyl-2-p-hydroxyphenyl-aethylen 
• 18648-74-3 2,2-diphenyl-1-(4-methoxyphenyl)ethylene 
• 56982-85-5 (2-(2,4-dichlorophenyl)ethene-1,1-diyl)dibenzene 
• 18720-10-0 (2-(2-methoxyphenyl)ethene-1,1-diyl)dibenzene 
• 18648-69-6 (2-(2-nitrophenyl)ethene-1,1-diyl)dibenzene 
• 34881-12-4 dimethyl 1,1-diphenyl-1-hydroxymethylphosphonate 

Relevant academic research and scientific papers

Preparation method of large-steric-hindrance alkyl substituted phosphite diester

The invention discloses a preparation method of large-steric-hindrance alkyl substituted phosphite diester, and relates to a novel method for preparing the large-steric-hindrance alkyl substituted phosphite diester compound which is difficult to synthesiz

Rh(I)-Catalyzed Arylation of α-Diazo Phosphonates with Aryl Boronic Acids: Synthesis of Diarylmethylphosphonates

An efficient synthetic method for diarylmethylphosphonates is presented. A series of phosphonate derivatives with diverse functional groups can be accessed via a rhodium catalyzed cross-coupling reaction between α-diazo phosphonates and aryl boronic acids. Migratory insertion of rhodium carbene intermediates is postulated to be the critical step in this transformation.

Rh(I)-catalyzed cross-coupling of α-diazoesters with arylsiloxanes

An Rh(I)-catalyzed cross-coupling of diazoesters with arylsiloxanes has been successfully achieved. This transformation is a new method for the construction of the C(sp3)-C(sp2) bond, thus providing an alternative synthesis of α-aryl esters. Rh(I)-carbene migratory insertion has been proposed to be involved in this coupling reaction. The reaction represents the first example of utilizing arylsiloxane as the coupling partner in the carbene-involved cross-coupling reactions.

Compatibility of Various Carbanion Nucleophiles with Heteroaromatic Nucleophilic Substitution by the SRN1 Mechanism

Carbanions generated from 2,4,4-trimethyl-2-oxazoline (1a), 2-benzyl-4,4-dimethyl-2-oxazoline (1b), 2,4-dimethylthiazole (13a), 2-benzyl-4-methylthiazole (13b), N,N-dimethylacetamide (17a), tert-butyl acetate (17b), ethyl phenylacetate (17c), N-methyl-N-phenyl-2-butenamide (22), tert-butyl 3-butenoate (25), and dimethyl methylphosphonate (29a) by means of KNH2 in liquid NH3 all reacted with 2-bromopyridine (2) via photoassisted reactions that exhibited characteristics of the SRN1 mechanism. Similar results were obtained in reactions of these carbanions with other substrates, including 2-chloroquinoline (6), iodobenzene (9), bromobenzene (10), and bromomesitylene (11).

INSERTION OF CARBENES INTO P-H BONDS. 5. SYNTHESIS OF NEW PHOSPHONATES AND PHOSPHINATES IN REACTIONS CATALYSED BY Cu, Pd, Rh, Ni COMPLEXES

Cu(OTf)2 and Cu(acac)2 were found to be the most effective catalysts in the reaction of diazo compounds Ph2CN2 (1a), EtOC(O)CHN2 (1b), MeOC(O)CHN2 (1c), MeC(O)CN2C(O)OMe (1d), ClCH2C(O)CHN2 (1e) and CH2N2 (1f) with hydrophosphoryl compounds (MeO)2P(O)H (2a), (t-BuO)2P(O)H (2b), Ph(MeO)P(O)H (2c), (EtO)2P(O)H (2d) and P(O)H (2e) resulting in P-C bond formations.Cu, Pd and Rh acetates and Ni(acac)2 have a much lower efficiency.Chlorines in Cl3CC(O)CH2P(O)(OMe)2 (3k) and Cl2CHC(O)CH2P(O)(OMe)2 (3l) are reduced in the copper catalysed Atherton-Todd reaction.Key words: Catalyst; diazo compound; hydrophosphoryl compound; insertion; phosphonate; phosphinate.