54966-20-0

Basic information

• Product Name: 2-Piperidinecarboxylic acid, 1-formyl- (9CI)
• Synonyms: 2-Piperidinecarboxylic acid, 1-formyl- (9CI);1-Formyl-2-piperidinecarboxylic acid
• CAS NO: 54966-20-0
• Molecular Formula: C₇H₁₁NO₃
• Molecular Weight: 157.16714
• Product Categories: ALDEHYDE
• Mol File: 54966-20-0.mol
• Article Data: 9

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-Piperidinecarboxylic acid, 1-formyl- (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Piperidinecarboxylic acid, 1-formyl- (9CI)(54966-20-0)
• EPA Substance Registry System: 2-Piperidinecarboxylic acid, 1-formyl- (9CI)(54966-20-0)

Safety Data

• Hazardous Substances Data: 54966-20-0(Hazardous Substances Data)

Upstream product

• 64-18-6 formic acid 
• 3105-95-1 pipecolinic acid 
• 4043-87-2 pipecolic Acid 

Downstream Products

• 1178549-20-6 C₂₁H₂₉N₃O₃ 
• 1178549-18-2 C₂₁H₂₉N₃O₃ 
• 87281-43-4 methyl 5,6,7,8-tetrahydro-1-indolizinylcarboxylate 
• 61009-77-6 5,6,7,8-tetrahydroindolizine-1-carboxylic acid ethyl ester 
• 1448525-91-4 N-(4-hydroxyphenyl)-3-{6-[((3S)-3-(4-morpholinylmethyl)-3,4-dihydro-2(1H)-isoquinolinyl)carbonyl]-1,3-benzodioxol-5-yl}-N-phenyl-5,6,7,8-tetrahydro-1-indolizine carboxamide hydrochloride 

Relevant articles and documents

Synthetic Cathinone Analogues Structurally Related to the Central Stimulant Methylphenidate as Dopamine Reuptake Inhibitors

Synthetic cathinones are, primarily, stimulant drugs of abuse that act at monoamine transporters (e.g., the dopamine transporter or DAT) as releasing agents or as reuptake inhibitors. In the past few years, the emergence of >150 new synthetic cathinones has attracted considerable attention from medical and law enforcement communities. threo-Methylphenidate (tMP), used clinically for the treatment of ADHD and narcolepsy, is also a DAT reuptake inhibitor. tMP is somewhat structurally similar to abused cathinone stimulants, and the structure-activity relationships (SAR) of tMP have been well-defined. Hence, available tMP literature might assist in understanding the SAR of synthetic cathinones, about which less is known. In the present study, we synthesized and examined eight 2-benzoylpiperidine analogues (4, 6-12) to determine if tMP SAR might be applicable to cathinone SAR. The benzoylpiperidine analogues were evaluated in a competition assay using live-cell imaging against APP+ in HEK293 cells stably expressing hDAT and in cells coexpressing DAT and voltage-gated Ca2+ channels. All compounds were found to be DAT reuptake inhibitors, and a significant correlation was obtained between the potency of the benzoylpiperidines and tMP binding data (r = 0.91), suggesting that the SAR of tMP analogues might be directly applicable to certain synthetic cathinones as DAT reuptake inhibitors.

New indolizine compound, preparation method thereof and pharmaceutical compositions containing them (by machine translation)

The invention of the formula (I) compound, Wherein R a, R b, R c, R d, T, R 3, R 4, R 5, X, Y and Het as defined in the description. The invention also relates to a medicament containing the above-mentioned compounds. (by machine translation)

PHOSPHATE COMPOUNDS, A PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM

Compounds of formula (I): wherein X, Y, A1, A2, Ra, Rb, Rc, Rd, R3, R4, T and R5 are as defined in the description. Medicinal products containing the same which are useful in treating pathologies involving a deficit in apoptosis, such as cancer, auto-immune diseases, and diseases of the immune system.