87281-43-4Relevant academic research and scientific papers
X=Y-ZH Systems as Potential 1,3-Dipoles. Part 42. Decarboxylative Three Carbon Ring Expansion of Cyclic Secondary α-Amino Acids via Azomethine Ylide Formation.
Ardill, Harriet,Grigg, Ronald,Malone, John F.,Sridharan, Visuvanathar,Thomas, W. Anthony
, p. 5067 - 5082 (1994)
Cyclic 5- and 6-membered secondary α-amino acids react with formaldehyde and acetylenic dipolarophiles via azomethine ylide formation, cycloaddition and subsequent ring expansion to give 8- and 9-membered rings respectively.Ring expansion occurs by reaction of the bridgehead nitrogen of the initial bicyclic cycloadduct with a further molecule of dipolarophile to give a zwitterion which triggers the ring expansion.Dynamic p.m.r. studies show that ring inversion between pairs of mirror image conformations of the medium ring products are occuring with inversion barriers of 13-14.6 kcal/mol.
2,3-DIHYDRO-1H-PYRROLIZINE-7-FORMAMIDE DERIVATIVE AND APPLICATION THEREOF
-
, (2021/04/16)
The present application relates to a 2,3-dihydro-1H-pyrrolizine-7-formamide derivative as a nucleoprotein inhibitor and a use in preparation of a drug for treating HBV related diseases. The present application specifically relates to a compound represented by formula (II), and isomers or pharmaceutically acceptable salts thereof.
HEPATITIS B CAPSID ASSEMBLY MODULATORS
-
Paragraph 0358; 0360, (2019/12/30)
Described herein are hepatitis B capsid assembly modulators and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful for the treatment of hepatitis B.
New indolizine compound, preparation method thereof and pharmaceutical compositions containing them (by machine translation)
-
Paragraph 0106; 0107; 0108; 0109, (2016/10/09)
The invention of the formula (I) compound, Wherein R a, R b, R c, R d, T, R 3, R 4, R 5, X, Y and Het as defined in the description. The invention also relates to a medicament containing the above-mentioned compounds. (by machine translation)
INDOLIZINE COMPOUNDS, A PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
-
Paragraph 0075-0078, (2016/07/27)
Compounds of formula (I) wherein Ra, Rb, Rc, Rd, T, R3, R4, R5, X, Y and Het are as defined in the description. Medicinal products containing the same which are useful in treating pathologies involving a deficit in apoptosis, such as cancer, auto-immune diseases, and diseases of the immune system.
PHOSPHATE COMPOUNDS, A PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
-
Paragraph 0074-0077, (2015/02/19)
Compounds of formula (I): wherein X, Y, A1, A2, Ra, Rb, Rc, Rd, R3, R4, T and R5 are as defined in the description. Medicinal products containing the same which are useful in treating pathologies involving a deficit in apoptosis, such as cancer, auto-immune diseases, and diseases of the immune system.
INDOLIZINE COMPOUNDS, A PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
-
Paragraph 0061 - 0064, (2015/02/25)
Compounds of formula (I): wherein Ra, Rb, Rc, Rd, R1, R2, R3, R4, R5, X, Y and Het are as defined in the description. Medicinal products containing the same which are useful in treating pathologies involving a deficit in apoptosis, such as cancer, auto-immune diseases, and diseases of the immune system.
NEW ISOINDOLINE OR ISOQUINOLINE COMPOUNDS, A PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
-
Page/Page column 51, (2015/02/19)
Compounds of formula (I): (I) wherein Het, R3, R4, R5, R7, R8, R9, T, p, p', q, and q' are as defined in the description are pro-apoptotic agents useful in the treatment of cancers and of a
A One-pot Three Carbon Decarboxylative Ring Expansion of Cyclic Secondary Amino Acids. X-Ray Crystal Structure of a Substituted 1-Azacyclo-octa-2,4-diene
Ardill, Harriet,Grigg, Ronald,Sridharan, Visuvanathar,Malone, John
, p. 1296 - 1298 (2007/10/02)
Heating cyclic secondary α-amino acids with an excess of paraformaldehyde or formalin and methyl propiolate or dimethyl acetylenedicarboxylate leads to a decarboxylative ring expansion giving 8- and 9-membered cyclic aza-dienes via an azomethine ylide; the X-ray crystal structure of a substituted 1-azacyclo-octa-2,4-diene shows it to have an irregular tub conformation.
