87281-43-4Relevant academic research and scientific papers
X=Y-ZH Systems as Potential 1,3-Dipoles. Part 42. Decarboxylative Three Carbon Ring Expansion of Cyclic Secondary α-Amino Acids via Azomethine Ylide Formation.
Ardill, Harriet,Grigg, Ronald,Malone, John F.,Sridharan, Visuvanathar,Thomas, W. Anthony
, p. 5067 - 5082 (1994)
Cyclic 5- and 6-membered secondary α-amino acids react with formaldehyde and acetylenic dipolarophiles via azomethine ylide formation, cycloaddition and subsequent ring expansion to give 8- and 9-membered rings respectively.Ring expansion occurs by reaction of the bridgehead nitrogen of the initial bicyclic cycloadduct with a further molecule of dipolarophile to give a zwitterion which triggers the ring expansion.Dynamic p.m.r. studies show that ring inversion between pairs of mirror image conformations of the medium ring products are occuring with inversion barriers of 13-14.6 kcal/mol.
2,3-DIHYDRO-1H-PYRROLIZINE-7-FORMAMIDE DERIVATIVE AND APPLICATION THEREOF
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, (2021/04/16)
The present application relates to a 2,3-dihydro-1H-pyrrolizine-7-formamide derivative as a nucleoprotein inhibitor and a use in preparation of a drug for treating HBV related diseases. The present application specifically relates to a compound represented by formula (II), and isomers or pharmaceutically acceptable salts thereof.
HEPATITIS B CAPSID ASSEMBLY MODULATORS
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Paragraph 0358; 0360, (2019/12/30)
Described herein are hepatitis B capsid assembly modulators and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful for the treatment of hepatitis B.
INDOLIZINE COMPOUNDS, A PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
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, (2016/07/27)
Compounds of formula (I) wherein Ra, Rb, Rc, Rd, T, R3, R4, R5, X, Y and Het are as defined in the description. Medicinal products containing the same which are useful in treating pathologies involving a deficit in apoptosis, such as cancer, auto-immune diseases, and diseases of the immune system.
New indolizine compound, preparation method thereof and pharmaceutical compositions containing them (by machine translation)
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Paragraph 0106; 0107; 0108; 0109, (2016/10/09)
The invention of the formula (I) compound, Wherein R a, R b, R c, R d, T, R 3, R 4, R 5, X, Y and Het as defined in the description. The invention also relates to a medicament containing the above-mentioned compounds. (by machine translation)
NEW ISOINDOLINE OR ISOQUINOLINE COMPOUNDS, A PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
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Page/Page column 51, (2015/02/19)
Compounds of formula (I): (I) wherein Het, R3, R4, R5, R7, R8, R9, T, p, p', q, and q' are as defined in the description are pro-apoptotic agents useful in the treatment of cancers and of a
PHOSPHATE COMPOUNDS, A PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
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, (2015/02/19)
Compounds of formula (I): wherein X, Y, A1, A2, Ra, Rb, Rc, Rd, R3, R4, T and R5 are as defined in the description. Medicinal products containing the same which are useful in treating pathologies involving a deficit in apoptosis, such as cancer, auto-immune diseases, and diseases of the immune system.
INDOLIZINE COMPOUNDS, A PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
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, (2015/02/25)
Compounds of formula (I): wherein Ra, Rb, Rc, Rd, R1, R2, R3, R4, R5, X, Y and Het are as defined in the description. Medicinal products containing the same which are useful in treating pathologies involving a deficit in apoptosis, such as cancer, auto-immune diseases, and diseases of the immune system.
A One-pot Three Carbon Decarboxylative Ring Expansion of Cyclic Secondary Amino Acids. X-Ray Crystal Structure of a Substituted 1-Azacyclo-octa-2,4-diene
Ardill, Harriet,Grigg, Ronald,Sridharan, Visuvanathar,Malone, John
, p. 1296 - 1298 (2007/10/02)
Heating cyclic secondary α-amino acids with an excess of paraformaldehyde or formalin and methyl propiolate or dimethyl acetylenedicarboxylate leads to a decarboxylative ring expansion giving 8- and 9-membered cyclic aza-dienes via an azomethine ylide; the X-ray crystal structure of a substituted 1-azacyclo-octa-2,4-diene shows it to have an irregular tub conformation.
