54966-45-9

Upstream product

• 28525-69-1 (4E)-5-phenyl-4-pentenoic acid 
• 17920-83-1 5-phenyl-4-pentenoic acid 
• 100-52-7 benzaldehyde 
• 119793-72-5 (E)-2-(3-phenyl-allyl) malonic acid dimethyl ester 
• 4392-24-9 Cinnamyl bromide 
• 4407-36-7 (2E)-3-phenyl-2-propen-1-ol 
• 4192-77-2 ethyl cinnamate 

Relevant academic research and scientific papers

Hexafluoroisopropanol-Promoted Haloamidation and Halolactonization of Unactivated Alkenes

Pyrrolidine and piperidine derivatives bearing halide functional groups are prevalent building blocks in drug discovery as halides can serve as an anchor for post-modifications. In principle, one of the simplest ways to build these frameworks is the haloa

Solvent and catalyst-free bromofunctionalization of olefins using a mechanochemical approach

Bromofunctionalizations of olefins are an important class of chemical transformations.N-Bromoimide reagents are commonly used in these reactions but catalysts and chlorinated solvents are often employed to achieve a reasonable reaction rate. In this repor

Organoselenium Accelerated Bromolactonization Reaction

A highly efficient and regioselective bromolactonization protocol is reported. The quantitative formation of synthetically versatile bromolactones occurs in the presence of only 0.1 mol % of an organoselenium compound, coined DECAD herein, within 90 min.

trans-Cyclooctenes as Halolactonization Catalysts

The strained olefins in trans-cyclooctenes serve as efficient catalysts for halolactonizations, including bromolactonizations and iodolactonizations. The trans-cyclooctene framework is essential for excellent catalytic performance, and the substituents also play important roles in determining efficiency. These results are the first demonstration of catalysis by a trans-cyclooctene.

Studies toward Lewis basic thiocarbamate and thiourea mediated bromolactonization: The effect of a trace amount of water on the reactivity and enantioselectivity

The effects of trace amounts of water on thiocarbamate- and thiourea-catalyzed bromolactonization reactions are studied. It was found that the thiourea- and the N-Me thiocarbamate-catalyzed bromolactonization reactions were sensitive to trace amounts of m

Aminothiocarbamate-catalyzed asymmetric bromolactonization of 1,2-disubstituted olefinic acids

An efficient and enantioselective bromolactonization of 1,2-disubstituted olefinic acids using an amino-thiocarbamate catalyst has been developed, resulting in the formation of δ-lactones containing two chiral centers with up to 99% yield, 95% ee.

Lewis base catalysis of bromo- and iodolactonization, and cycloetherification

Lewis base catalyzed bromo- and iodolactonization reactions have been developed and the effects of catalyst structure on rate and cyclization selectivity have been systematically explored. The effects of substrate structure on halolactonization reactions

LEAD(IV) ACETATE-METAL HALIDE REAGENTS III. A NEW METHOD FOR THE SYNTHESIS OF TETRAHYDROFURAN, TETRAHYDROPYRAN AND LACTONE DERIVATIVES

A new method for the synthesis of tetrahydrofuran, tetrahydropyran and lactone derivatives from γδ-, δε-unsaturated alcohols and βγ-, γδ-carboxylic acids is described.