54993-52-1Relevant academic research and scientific papers
A facile route to N-fused pyrrole lactams
Yang, Zhi,Fu, Decai,Shao, Ruimin,Zhang, Shoufang
, p. 790 - 791 (2007/10/03)
N-Fused pyrrole lactams (1a-d) were prepared by substitution and cyclization of methyl 1-(2-bromoethane)pyrrole carboxylate in one-pot. The latter was obtained by treatment of methyl pyrrole-2-carboxylate with excess 1,2-dibromoethane containing NaOH in the presences of PTC.
Synthesis of 2-Methylpyrrolopyrazin-1(2H)-one
Brimble, Margaret A.,Brimble, Mark T.,Hodges, Richard,Lane, Geoffrey A.
, p. 1583 - 1590 (2007/10/02)
The synthesis of 2-methylpyrrolopyrazin-1(2H)-one (2) present in the insect feeding deterrent peramine (1) through oxidation of the saturated lactam (3) is described.The preparation of the related 6-methyl-1H-pyrrolopyridin-7(6H)-one (12) trough a Lewias-acid-catalysed cyclization of the amide acetal (7) is also described.
