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Chlorhexidine Manufacturer/High quality/Best price/In stock
Cas No: 55-56-1
USD $ 3.0-3.0 / Kilogram 1 Kilogram 1-100 Metric Ton/Month Hangzhou Dayangchem Co., Ltd. Contact Supplier
chlorhexidine 55-56-1
Cas No: 55-56-1
No Data 25 Kilogram 5000 Metric Ton/Month Hefei TNJ chemical industry co.,ltd Contact Supplier
High quality Chlorhexidine supplier in China
Cas No: 55-56-1
No Data No Data No Data Simagchem Corporation Contact Supplier
Chlorhexidine (base and/or unspecified salts)
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No Data No Data No Data Chemwill Asia Co., Ltd. Contact Supplier
chlorhexidine
Cas No: 55-56-1
USD $ 1.0-2.0 / Kilogram 1 Kilogram 200 Metric Ton/Month Crovell Biotech (Hebei) Co., Ltd. Contact Supplier
Chlorhexidine
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No Data 1 Kilogram 600 Kilogram/Month HENAN SUNLAKE ENTERPRISE CORPORATION Contact Supplier
55-56-1 1,6-Di(N-p-chlorophenylbiguanidino)hexane
Cas No: 55-56-1
USD $ 8900.0-8900.0 / Gram 1 Gram 200 Gram/Day Henan Tianfu Chemical Co., Ltd. Contact Supplier
White crystalline power Chlorhexidine HCL CAS NO 55-56-1 Chlorhexidine Hydrochloride
Cas No: 55-56-1
No Data 100 Gram 20000 Kilogram/Day Hubei XinRunde Chemical Co., Ltd Contact Supplier
Chlorhexidine 99% purity stable supply
Cas No: 55-56-1
USD $ 100.0-100.0 / Gram 10 Gram 1000 Kilogram/Day CHINA HUASHENG INTERNATIONAL LIMITED Contact Supplier
Chlorhexidine
Cas No: 55-56-1
USD $ 1.0-1.5 / Gram 1 Gram 1-100 Metric Ton/Month Baowei Technology Qinhuangdao Co., Ltd Contact Supplier

55-56-1 Usage

Chemical Properties

solid

Definition

ChEBI: A bisbiguanide compound with a structure consisting of two (p-chlorophenyl)guanide units linked by a hexamethylene bridge.

Uses

Chlorhexidine is an antibacterial used for numerous applications. It is a cationic polybiguanide (bisbiguanide) used primarily as its salts, dihydrochloride, diacetate, and digluconate. Chlorhexidine is one of those drugs which are enlisted/included in the World Health Organization's List of Essential Medicines, a list of the most important drugs needed in a basic health system.
  1. Chlorhexidine is used as a germicidal compound in teat dips. Also used as navel treatment, udder and eye wash, surgical scrub and sterilization material.
  2. Chlorhexidine is used primarily as a topical antiseptic/disinfectant in wound healing, at catheterization sites, in various dental applications and in surgical scrubs. it is used as an antibacterial agent in humans to control gingivitis and over all plaque control in preventative dentistry.
  3. Hydrogenolysis of benzyl-nitrogen bonds.
  4. Bacteriostatic;Detergent.

Description

Chlorhexidine is a cationic broad-spectrum antimicrobial agent belonging to the bis(biguanide) family. Its mechanism of action involves destabilization of the outer bacterial membrane. It is effective on both Gram-positive and Gram-negative bacteria, although it is less effective with some Gram-negative bacteria. It has both bactericidal and bacteriostatic mechanisms of action.
Chlorhexidine's antimicrobial effects are associated with the attractions between chlorhexidine (cation) and negatively charged bacterial cells. After chlorhexidine is absorpted onto the organism's cell wall, it disrupts the integrity of the cell membrane and causes the leakage of intracellular components of the organisms.
Aqueous solutions of chlorhexidine are most stable within the pH range of 5-8. Above pH 8.0 chlorhexidine base is precipitated and in more acid conditions there is gradual deterioration of activity because the compound is less stable. Chlorhexidine is used primarily as a topical antiseptic/disinfectant in wound healing, at catheterization sites, in various dental applications and in surgical scrubs. It has a LD-50 orally in mice as a diacetate at 2gm./kg. In digluconate form the LD-50 is 1800 gm./kg.

History

Chlorhexidine (CHX) was the first antimicrobial agent shown to inhibit dental plaque formation and the development of chronic gingivitis (Loe and Schiott 1970).
Chlorhexidine is a cationic chlorophenyl bisbiguanide antiseptic.
Bisbiguanides are the primary second generation antiplaque agents exhibiting considerable substantivity and broad spectrum antibacterial properties.
In dental medicine, CHX was initially used for disinfection of the oral cavity prior to oral surgical procedures and in endodontics. Plaque inhibition by CHX was first investigated in 1969 (Schroeder) but the first controlled clinical study was performed by Loe and Schiott (1970). [16] This study showed that rinsing for 60 sec, twice a day with 10 ml of a 0.2% (20 mg dose) CHX gluconate solution, in the absence of normal tooth cleaning, inhibited plaque regrowth and the development of gingivitis.
CHX is one of the most widely investigated and used antiplaque agents.The advantage of CHX over other cationic agents is that it can bind strongly to many sites in the oral cavity and is released slowly over 7 to 12 hours after rinsing, thus providing considerable substantivity and a sustained antimicrobial effect restricting bacterial proliferation. CHX binds strongly with anionic glycoproteins and phosphoproteins on the oral mucosa and tooth pellicle in addition to its property of binding to the surfaces of bacterial cell membranes affecting the cells ability to adhere. CHX is considered the most potent chemotherapeutic agent currently available.
InChI:InChI=1S/C22H30Cl2N10/c23-15-5-9-17(10-6-15)31-21(27)33-19(25)29-13-3-1-2-4-14-30-20(26)34-22(28)32-18-11-7-16(24)8-12-18/h5-12H,1-4,13-14H2,(H5,25,27,29,31,33)(H5,26,28,30,32,34)

55-56-1 Well-known Company Product Price

Brand (Code)Product description CAS number Packaging Price Detail
Aldrich (282227)  Chlorhexidine  ≥99.5% 55-56-1 282227-5G 3,803.67CNY Detail
Aldrich (282227)  Chlorhexidine  ≥99.5% 55-56-1 282227-1G 1,107.99CNY Detail
USP (1111001)  Chlorhexidine  United States Pharmacopeia (USP) Reference Standard 55-56-1 1111001-200MG 4,588.74CNY Detail
Sigma-Aldrich (C1510000)  Chlorhexidine  European Pharmacopoeia (EP) Reference Standard 55-56-1 C1510000 1,880.19CNY Detail
Sigma-Aldrich (PHR1421)  Chlorhexidine  pharmaceutical secondary standard; traceable to USP, PhEur 55-56-1 PHR1421-1G 718.73CNY Detail

55-56-1SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 13, 2017

Revision Date: Aug 13, 2017

1.Identification

1.1 GHS Product identifier

Product name chlorhexidine

1.2 Other means of identification

Product number -
Other names Chlorhexidin

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:55-56-1 SDS

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