5500-46-9Relevant articles and documents
XtalFluor-E mediated proto-functionalization of: N -vinyl amides: Access to N -acetyl N, O -acetals
Yi,Gholami,Morrow,Borhan
, p. 9570 - 9574 (2017/11/30)
XtalFluor-E has been extensively used in a broad range of reactions in the past few years. Here we report its use with protic nucleophiles in a catalytic manner for the in situ generation of protons that lead to the proto-functionalization of activated ol
Structure-Dependent Nickel-Catalysed Transposition of N -Allylamides to E- or Z-Enamides
Weber, Felicia,Steinlandt, Philipp S.,Ballmann, Monika,Hilt, Gerhard
, p. 440 - 450 (2016/12/24)
The nickel-catalysed transposition of a carbon-carbon double bond of N-allyl and N-homoallyl amides is described. While the transposition of acyclic amides gave very high Z-selectivity of the enamides, corresponding cyclic N-allyl amides led exclusively t
Site-Selective Silylation of Aliphatic C-H Bonds Mediated by [1,5]-Hydrogen Transfer: Synthesis of α-Sila Benzamides
Liu, Pei,Tang, Jinghua,Zeng, Xiaoming
, p. 5536 - 5539 (2016/11/17)
The first example of site-selective silylation of C(sp3)-H bonds mediated by a [1,5]-hydrogen transfer is reported. This reaction occurs selectively at the α-position of benzamides with a combination of tert-butylmagnesium chloride and a catalytic amount of 4,4′-di-tert-butylbipyridine (dtbpy) ligand and provides a facile route for the creation of biologically interesting α-sila benzamides. Late-stage functionalization of the incorporated silyl moieties facilitates the synthesis of N-formyl, cis-enamine, β-hydroxyl, amino, and pyrrole-containing derivatives.
