55022-91-8

Usage

Uses

Used in Pharmaceutical Industry:
Quinuclidine-4-carbaldehyde is used as a key intermediate in the synthesis of life-saving medications and therapeutic compounds. Its importance in the production of pharmaceuticals is highlighted by its role in creating various medications that contribute to human health.
Used in Agrochemical Production:
As a building block, quinuclidine-4-carbaldehyde is utilized in the synthesis of agrochemicals, contributing to the development of products that enhance agricultural productivity and crop protection.
Used as a Catalyst in Organic Reactions:
Quinuclidine-4-carbaldehyde is employed as a catalyst to facilitate various organic reactions, improving the efficiency and selectivity of chemical processes in research and industrial applications.
Used in the Synthesis of Antimalarial Drugs:
Quinuclidine-4-carbaldehyde is used as an intermediate in the synthesis of antimalarial drugs, playing a crucial role in the development of medications that combat malaria, a significant global health concern.

Upstream product

• 22766-68-3 azabicyclo[2.2.2]octane-4-carboxylic acid ethyl ester 
• 869112-14-1 1-(2-chloroethyl)-4-piperidinecarboxylic acid ethyl ester 
• 1126-09-6 4-carbethoxypiperidine 
• 26458-78-6 4-cyanoquinuclidine 
• 26608-58-2 4-hydroxymethylquinuclidine 

Downstream Products

• 1006602-20-5 C₁₆H₂₀N₂O₃ 
• 52547-86-1 4-ethynylquinuclidine 
• 1609072-64-1 C₃₂H₃₄ClN₃O₅ 
• 1609072-58-3 C₃₂H₃₅N₃O₅ 
• 1609072-55-0 C₃₂H₃₅N₃O₆ 
• 1609072-36-7 C₃₂H₃₄ClN₃O₆ 
• 1609072-37-8 C₃₂H₃₄ClN₃O₆ 
• 1609072-34-5 C₃₂H₃₄ClN₃O₅ 

Relevant academic research and scientific papers

6. A Reexamination of Inductive Substituent Constants Derived from pKa Values of 4-Substituted Quinuclidines. Polar Effects. Part VIII

pKa Values of 42 quinuclidinium perchlorates I have been measured in 0.1M aqueous KCl-solution.In a few cases small corrections of earlier thermodynamic pKa values are indicated.These measurements, in conjuction with recent X-ray structure determinations, confirm the reliability of the inductive substituent constants ?qI derived from them.

ALKYNYL QUINAZOLINE COMPOUNDS

The present disclosure relates to compounds of Formula (I'): and pharmaceutically acceptable salts and stereoisomers thereof. The present disclosure also relates to methods of preparation these compounds, compositions comprising these compounds, and methods of using them in the prevention or treatment of abnormal cell growth in mammals, especially humans.

PROGRANULIN MODULATORS AND METHODS OF USING THE SAME

Provided herein are compounds of formula (I) that modulate progranulin and methods of using the compounds in progranulin- associated disorders, such as Frontotemperal lobe dementia (FTLD).

QUINAZOLINE DERIVATIVES AS TYROSINE KINASE INHIBITOR, COMPOSITIONS, METHODS OF MAKING THEM AND THEIR USE

The present disclosure relates to new compounds or pharmaceutically acceptable salts or stereoisomers thereof of formula I as inhibitors of receptor tyrosine kinases (RTK), in particular extracellular mutants of ErbB-receptors. The present disclosure also relates to methods of preparation these compounds, compositions comprising these compounds, and methods of using them in the treatment of cancer in mammals (e.g. humans).

2 - Substituted cephem compound-containing pharmaceutical composition

PROBLEM TO BE SOLVED: To provide a cephem compound which has a strong antimicrobial activity, in particular effective against various β-lactamase producing Gram negative bacteria, and a composition comprising the compound.SOLUTION: The present invention provides a pharmaceutical composition comprising a compound represented by formula (I), an ester at a carboxyl group, an amino-protected compound when the amino is present on a ring in the 7-side chain, or a pharmaceutically acceptable salt thereof.

Halogen-Bonded Supramolecular Capsules in the Solid State, in Solution, and in the Gas Phase

Supramolecular capsules were assembled by neutral halogen bonding (XB) and studied in the solid state, in solution, and in the gas phase. The geometry of the highly organized capsules is shown by an X-ray crystal structure which features the assembly of t

2 SUBSTITUTED CEPHEM COMPOUNDS

The compounds of formula (I) of the subject invention are related to 2-substituted cephem compounds, which have a wide antimicrobial spectrum, in particular exhibit potent antimicrobial activity against beta-lactamase producing Gram negative bacteria, and pharmaceutical compositions comprising the same.

2-ALKYLBENZOXAZOLE CARBOXAMIDES AS 5HT3 MODULATORS

Compounds of formulae I and II: are disclosed as 5-HT3 inhibitors. Those compounds are useful in treating CINV, IBS-D and other diseases and conditions.