5503-73-1

Usage

Uses

Used in Pharmaceutical Industry:
2-AMINO-4,5-DIPHENYL-3-FURONITRILE is used as a building block for the synthesis of various bioactive compounds due to its unique molecular structure and properties. It plays a crucial role in the development of new drugs and pharmaceuticals, contributing to the advancement of medicinal chemistry.
Used in Organic Synthesis:
In the field of organic synthesis, 2-AMINO-4,5-DIPHENYL-3-FURONITRILE is utilized as an intermediate for the production of a wide range of chemical products. Its versatility in chemical reactions allows for the creation of diverse compounds with potential applications in various industries.

InChI:InChI=1/C22H16N2O3/c25-21(23-18-11-9-15-5-1-2-7-17(15)13-18)14-27-22(26)20-12-10-16-6-3-4-8-19(16)24-20/h1-13H,14H2,(H,23,25)

Upstream product

• 19179-21-6 2-Methoxy-2,3-diphenyl-oxirane 
• 20334-42-3 sodium dicyanomethanide 
• 88876-86-2 <(1,2-Diphenyl-2-hydroxy)ethylidene>propanedinitrile 
• 119-53-9 2-hydroxy-2-phenylacetophenone 
• 109-77-3 malononitrile 
• 100-52-7 benzaldehyde 
• 134-81-6 benzil 
• 2700-22-3 Benzylidenemalononitrile 
• 312307-43-0 2-(2-oxo-1,2-diphenylethyl)propanedinitrile 

Downstream Products

• 5207-52-3 4-amino-5,6-diphenylfuro<2,3-b>pyrimidine 
• 23903-55-1 2-methyl-5,6-diphenyl-3H-furo[2,3-d]pyrimidine-4-thione 
• 75861-43-7 2-{[1-Furan-2-yl-meth-(E)-ylidene]-amino}-4,5-diphenyl-furan-3-carbonitrile 
• 75861-45-9 4,5-Diphenyl-2-{[1-thiophen-2-yl-meth-(E)-ylidene]-amino}-furan-3-carbonitrile 
• 128276-99-3 2-Dichloromethyl-5,6-diphenyl-furo[2,3-d]pyrimidin-4-ylamine 
• 142274-67-7 4-Imino-5,6-diphenyl-3-propyl-3,4-dihydro-1H-furo[2,3-d]pyrimidine-2-thione 
• 128277-16-7 4-Chloro-5,6-diphenyl-2-phenylsulfanylmethyl-furo[2,3-d]pyrimidine 
• 128277-17-8 5,6-Diphenyl-2-phenylsulfanylmethyl-furo[2,3-d]pyrimidin-4-ylamine 
• 54525-36-9 5-hydroxy-2-oxo-4,5-diphenyl-2,5-dihydro-pyrrole-3-carbonitrile 
• 88876-87-3 2-Amino-3-thioamido-4,5-diphenylfurane 
• 77651-33-3 2-Amino-4,5-diphenyl-furan-3-carboxylic acid amide 
• 142274-62-2 4-Imino-5,6-diphenyl-3-p-tolyl-3,4-dihydro-1H-furo[2,3-d]pyrimidine-2-thione 
• 75861-47-1 N-(4-{[(E)-3-Cyano-4,5-diphenyl-furan-2-ylimino]-methyl}-phenyl)-acetamide 
• 128277-08-7 4-Chloro-2-(4-nitro-benzyl)-5,6-diphenyl-furo[2,3-d]pyrimidine 

Relevant academic research and scientific papers

Acyl Radicals from Benzothiazolines: Synthons for Alkylation, Alkenylation, and Alkynylation Reactions

We describe herein a fundamentally new visible light-driven homolytic C-C bond breaking mode for the generation of acyl radicals from C2-acyl-substituted benzothiazolines. The reactive species can be used as versatile synthons for formal radical alkylatio

Benzothiazolines as radical transfer reagents: Hydroalkylation and hydroacylation of alkenes by radical generation under photoirradiation conditions

Novel radical transfer reagents under photoirradiation conditions were developed by the use of benzothiazoline derivatives. These reagents enabled both hydroalkylation and hydroacylation of alkenes under neutral conditions at ambient temperature without a

Microtubing-Reactor-Assisted Aliphatic C?H Functionalization with HCl as a Hydrogen-Atom-Transfer Catalyst Precursor in Conjunction with an Organic Photoredox Catalyst

Chlorine radical, which is classically generated by the homolysis of Cl2 under UV irradiation, can abstract a hydrogen atom from an unactivated C(sp3)?H bond. We herein demonstrate the use of HCl as an effective hydrogen-atom-transfer catalyst precursor activated by an organic acridinium photoredox catalyst under visible-light irradiation for C?H alkylation and allylation. The key to success relied on the utilization of microtubing reactors to maintain the volatile HCl catalyst. This photomediated chlorine-based C?H activation protocol is effective for a variety of unactivated C(sp3)?H bond patterns, even with primary C(sp3)?H bonds, as in ethane. The merit of this strategy is illustrated by rapid access to several pharmaceutical drugs from abundant unfunctionalized alkane feedstocks.

Corrole-imide dyads - Synthesis and optical properties

Two rarely seen building blocks have been incorporated into light absorbing arrays: corroles and 2,3-naphthalimides. General synthetic strategy consisting in direct condensation of formyl substituted aromatic imides with dipyrranes led to diverse range of

CH-01 is a hypoxia-activated prodrug that sensitizes cells to hypoxia/reoxygenation through inhibition of Chk1 and aurora A

The increased resistance of hypoxic cells to all forms of cancer therapy presents a major barrier to the successful treatment of most solid tumors. Inhibition of the essential kinase Checkpoint kinase 1 (Chk1) has been described as a promising cancer therapy for tumors with high levels of hypoxia-induced replication stress. However, as inhibition of Chk1 affects normal replication and induces DNA damage, these agents also have the potential to induce genomic instability and contribute to tumorigenesis. To overcome this problem, we have developed a bioreductive prodrug, which functions as a Chk1/Aurora A inhibitor specifically in hypoxic conditions. To achieve this activity, a key functionality on the Chk1 inhibitor (CH-01) is masked by a bioreductive group, rendering the compound inactive as a Chk1/Aurora A inhibitor. Reduction of the bioreductive group nitro moiety, under hypoxic conditions, reveals an electron-donating substituent that leads to fragmentation of the molecule, affording the active inhibitor. Most importantly, we show a significant loss of viability in cancer cell lines exposed to hypoxia in the presence of CH-01. This novel approach targets the most aggressive and therapy-resistant tumor fraction while protecting normal tissue from therapy-induced genomic instability.

Novel, Cyclically Substituted Furopyrimidine Derivatives and Use Thereof

The present application relates to novel, cyclically substituted furopyrimidine derivatives, methods for their production, their use for the treatment and/or prophylaxis of diseases and their use for the production of medicinal products for the treatment and/or prophylaxis of diseases, in particular for the treatment and/or prophylaxis of cardiovascular diseases.

A NHC-Involved, cascade, metal-free, and three-component synthesis of 2,3-diarylated fully substituted furans under solvent-free conditions

An efficient synthesis of 2,3-diarylated fully substituted furans was performed through the sequential reactions of Knoevenagel reaction, Stetter reaction catalyzed by NHC, and intramolecular cyclization under solvent-free conditions. The protocol has the

An Efficient synthesis of 2-aminofuran-3-carbonitriles via cascade Stetter-γ-ketonitrile cyclization reaction catalyzed by N-heterocyclic carbene

An efficient method for the synthesis of 4,5-disubstituted 2-aminofuran-3-carbonitriles via a cascade Stetter-γ-ketonitrile cyclization reaction of aromatic aldehydes with acylidenemalononitriles, catalyzed by N-heterocyclic carbenes, has been developed.

Fused Bicyclic and Tricyclic Pyrimidine Compounds as Tyrosine Kinase Inhibitors

Fused bicyclic or tricyclic compounds of formula (I): wherein A, B, C, X, Y, m, and n are defined herein. Also disclosed are a method for inhibiting EGFR kinase activity and a method for treating cancer with these compounds.

Identification, SAR studies, and X-ray Co-crystallographic analysis of a novel furanopyrimidine aurora kinase a inhibitor

Herein we reveal a simple method for the identification of novel Aurora kinase A inhibitors through substructure searching of an in-house compound library to select compounds for testing. A hydrazone fragment conferring Aurora kinase activity and heterocy