552-38-5 Usage
Description
Lithium salicylate is the lithium salt of salicylate, which is a kind of organic acid. Lithium salicylate may be a good alternative for treating bipolar disorder and other neuropsychiatric conditions as it was recently found that oral lithium salicylate was able to produce steady lithium levels for up to 48 hours in rats – without the toxic side effects typically linked with the rapid absorption of current FDA-approved lithium carbonate. It is also proposed that lithium salicylate is most effective drug in reducing self-harm and suicide.
The therapeutic effect of lithium salicylate allows for its application in diuretics. In addition, with the aid of its catalysis effect, this chemical can be employed as the catalysts for chemiluminescent system or trimer catalyst for aliphatic and aromatic isocyanates.
Sources
https://www.redorbit.com/news/health/1113093183/biploar-disorder-lithium-therapy-sodium-based-better-031214/
https://www.theguardian.com/society/2016/aug/14/lithium-should-be-more-widely-used-for-bipolar-disorder-researchers-say
https://www.sdrugs.com/?c=drug&s=lithium%20salicylate
Junquera, E.; Pena, L.; Aicart, E., Binding of sodium salicylate by beta-cyclodextrin or 2,6-di-O-methyl-beta-cyclodextrin in aqueous solution. J. Pharm. Sci. 1998, 87, 86-90.
Herbert, P. R.; Joseph, H. J., Chemiluminescent system catalysts. United Sates Patent 4626383 1986.
W.E., S.; H.T., K.; T., H., Trimer catalyst for aliphatic and aromatic isocyanates. United Sates Patent 5905151 1999.
Flammability and Explosibility
Notclassified
Purification Methods
Recrystallise it from EtOH (2mL/g) by partial evaporation. [Beilstein 10 H 59, 10 II 32, 10 III 93, 10 IV 126.]
Check Digit Verification of cas no
The CAS Registry Mumber 552-38-5 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 5,5 and 2 respectively; the second part has 2 digits, 3 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 552-38:
(5*5)+(4*5)+(3*2)+(2*3)+(1*8)=65
65 % 10 = 5
So 552-38-5 is a valid CAS Registry Number.
InChI:InChI=1/C7H6O3.Li/c8-6-4-2-1-3-5(6)7(9)10;/h1-4,8H,(H,9,10);/q;+1/p-1
552-38-5Relevant articles and documents
New MALDI matrices based on lithium salts for the analysis of hydrocarbons and wax esters
Horká, Petra,Vrkoslav, Vladimír,Hanus, Robert,Pecková, Karolina,Cva?ka, Josef
, p. 628 - 638 (2014/07/22)
Lithium salts of organic aromatic acids (lithium benzoate, lithium salicylate, lithium vanillate, lithium 2,5-dimethoxybenzoate, lithium 2,5-dihydroxyterephthalate, lithium α-cyano-4-hydroxycinnamate and lithium sinapate) were synthesized and tested as potential matrices for the matrix-assisted laser desorption/ionization (MALDI)-mass spectrometry analysis of hydrocarbons and wax esters. The analytes were desorbed using nitrogen laser (337.1 nm) and ionized via the attachment of a lithium cation, yielding [M + Li]+ adducts. The sample preparation and the experimental conditions were optimized for each matrix using stearyl behenate and n-triacontane standards. The performance of the new matrices in terms of signal intensity and reproducibility, the mass range occupied by matrix ions and the laser power threshold were studied and compared with a previously recommended lithium 2,5-dihydroxybenzoate matrix (LiDHB) (Cvac?ka and Svatos?, Rapid Commun. Mass Spectrom. 2003, 17, 2203). Several of the new matrices performed better than LiDHB. Lithium vanillate offered a 2-3 times and 7-9 times higher signal for wax esters and hydrocarbons, respectively. Also, the signal reproducibility improved substantially, making this matrix a suitable candidate for imaging applications. In addition, the diffuse reflectance spectra and solubility of the synthesized compounds were investigated and discussed with respect to the compound's ability to serve as MALDI matrices. The applicability of selected matrices was tested on natural samples of wax esters and hydrocarbons. Copyright 2014 John Wiley & Sons, Ltd. Copyright
