55247-90-0Relevant academic research and scientific papers
Comparative biological evaluation and G-quadruplex interaction studies of two new families of organometallic gold(I) complexes featuring N-heterocyclic carbene and alkynyl ligands
Meier-Menches, Samuel M.,Aikman, Brech,D?llerer, Daniel,Klooster, Wim T.,Coles, Simon J.,Santi, Nicolò,Luk, Louis,Casini, Angela,Bonsignore, Riccardo
, (2020)
Experimental organometallic gold(I) compounds hold promise for anticancer therapy. This study reports the synthesis of two novel families of gold(I) complexes, including N1-substituted bis-N-heterocyclic carbene (NHC) complexes of general formula [Au(N1-T
Nickel-Catalyzed Photodehalogenation of Aryl Bromides
Higginson, Bradley,Sanjosé-Orduna, Jesus,Gu, Yiting,Martin, Ruben
supporting information, p. 1633 - 1636 (2021/04/23)
Herein, we describe a Ni-catalyzed photodehalogenation of aryl bromides under visible-light irradiation that utilizes tetrahydrofuran as hydrogen source. The protocol obviates the need for exogeneous amine reductants or photocatalysts and is characterized by its simplicity and broad scope, including challenging substrate combinations.
Tethered N-Heterocyclic Carbene-Carboranyl Silver Complexes for Cancer Therapy
Holmes, Jordan,Kearsey, Rachel J.,Paske, Katie A.,Singer, Frances N.,Atallah, Suliman,Pask, Christopher M.,Phillips, Roger M.,Willans, Charlotte E.
, p. 2530 - 2538 (2019/07/02)
Silver complexes of tethered N-heterocyclic carbene-carboranyl ligands have been prepared and fully characterized. The first example of silver bonded directly to the cage of o-carborane has been identified in the solid state. The presence of a carboranyl
Synthesis of new allyl palladium complexes bearing purine-based NHC ligands with antiproliferative and proapoptotic activities on human ovarian cancer cell lines
Scattolin, Thomas,Caligiuri, Isabella,Canovese, Luciano,Demitri, Nicola,Gambari, Roberto,Lampronti, Ilaria,Rizzolio, Flavio,Santo, Claudio,Visentin, Fabiano
, p. 13616 - 13630 (2018/10/15)
A series of new palladium allyl complexes bearing purine-based carbenes derived from caffeine, theophylline and theobromine have been prepared and characterized by NMR spectroscopy, and elemental analysis and in two cases by single crystal X-ray diffraction. The cytotoxic and proapoptotic activities of compounds have been determined in vitro on human ovarian cancer A2780 and SKOV-3 cell lines. These experiments have shown that the palladium-allyl fragment induces a general cytotoxicity, but the choice of the supporting ligands is of paramount importance for achieving the best results. In particular complexes 4c, 4d and 5d exhibit a higher antiproliferative effect (IC50: 0.09, 0.81 and 0.85 μM respectively) than cisplatin (IC50: 1.5 μM) on A2780 cells, and 4d (IC50: 1.7 μM vs. 5.94 μM) on SKOV-3 cell line. Moreover in many cases it has been proved that the cytotoxicity of our complexes is associated with the induction of apoptosis.
Mechanochemical N-alkylation of imides
Bri?, Anamarija,Dud, Mateja,Margeti?, Davor
supporting information, p. 1745 - 1752 (2017/09/27)
The mechanochemical N-alkylation of imide derivatives was studied. Reactions under solvent-free conditions in a ball mill gave good yields and could be put in place of the classical solution conditions. The method is general and can be applied to various imides and alkyl halides. Phthalimides prepared under ball milling conditions were used in a mechanochemical Gabriel synthesis of amines by their reaction with 1,2-diaminoethane.
Highly efficient C-8 oxidation of substituted xanthines with substitution at the 1-, 3-, and 7- Positions using biocatalysts
Madyastha,Sridhar
, p. 677 - 680 (2007/10/03)
A bacterial consortium consisting of strains belonging to the genus Klebsiella and Rhodococcus quantitatively converts 1-, 3- and 7-substituted xanthines to their respective 8-oxo compounds.
Purines. XLIX. Synthesis and proton nuclear magnetic resonance study of 3,7-dialkylxanthines and 1,3,7-trialkylxanthines
Fujii,Saito,Tamura
, p. 2855 - 2862 (2007/10/02)
A general synthetic route to 3,7-dialkylxanthines (type 9) from 3,7-dialkyladenines (6) [hence from 3- or 7-alkyladenines (11 or 10)] has been established. The route started with ethoxycarbonylation of 1-alkyl-4-(alkylamino)1H-imidazole-5-carboxamides (7), readily obtainable from 6 by alkaline hydrolysis, and proceeded through cyclization of the resulting carbamates (8) under alkaline conditions. Alkylation of 9 with alkyl halide in N,N-dimethylformamide in the presence of anhydrous K2CO3 extended the above synthetic route to the 1,3,7-trialkylxanthine level (type 14). Hydrogenolytic deb nzylation of 3-benzyl-1,7-dimethylxanthine (16), prepared by following this general synthetic route, furnished paraxanthine (26) in fair yield. Conversion of 26 into 3-(4-hydroxy-3-nitrobenzyl)-1,7-dimethylxanthine (24), isomeric with the bryozoan purine phidolopin (2), was effected through aralkylation with 4-(methoxymethoxy)-3-nitrobenzyl bromide (28) followed by O-deprotection. On the basis of proton nuclear magnetic resonance data for the 3,7-dialkylxanthines (3 and 9b-i) and 1,3,7-trialkylxanthines (5 and 14-22) thus prepared, reliable criteria for distinguishing signals of N-alkyl substituents at various positions are put forward.
Les systemes biphasiques. 3. Alkylation des purines en catalyse par transfert de phase (1a)
Hedayatullah, Mir
, p. 249 - 251 (2007/10/02)
The phase transfer catalysed methylation of adenine gave selectively 9-methyladenine (98percent), while benzylation yields 9-benzyladenine as the major product accompanied by very small amounts of the 3-isomer.Alkylation of xanthine, theobromine and theophylline by the same technique gave also the corresponding N.alkyl derivatives in high yields, with no other O-alkylated regioisomer.These alkylation procedures, owing to their simplicity and selectivity, constitute a considerable improvement upon classical techniques.
