55253-39-9

Basic information

• Product Name: (R)-1-hydroxy-1-phenylpropan-2-one oxime
• Synonyms: (R)-1-hydroxy-1-phenylpropan-2-one oxime
• CAS NO: 55253-39-9
• Molecular Weight: 165.192
• Mol File: 55253-39-9.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: (R)-1-hydroxy-1-phenylpropan-2-one oxime(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-1-hydroxy-1-phenylpropan-2-one oxime(55253-39-9)
• EPA Substance Registry System: (R)-1-hydroxy-1-phenylpropan-2-one oxime(55253-39-9)

Safety Data

• Hazardous Substances Data: 55253-39-9(Hazardous Substances Data)

Upstream product

• 1798-60-3 (R)-1-hydroxy-1-phenyl-2-propanone 
• 93-55-0 1-phenyl-propan-1-one 
• 3516-69-6 3-hydroxy-2-methyl-1-phenyl-2-propen-1-one 

Downstream Products

• 492-41-1 (1R,2S)-norephedrine 
• 58550-13-3 C₉H₁₃NO 
• 3198-15-0 (1R,2S)-(-)-norephedrine hydrochloride 
• 50-98-6 ephedrine hydrochloride 
• 1798-60-3 (R)-1-hydroxy-1-phenyl-2-propanone 
• 37577-07-4 Norpseudoephedrine 

Relevant articles and documents

NOVEL PROCESS FOR THE PREPARATION OF R-PHENYLACETYLCARBINOL AND β-AMINOALCOHOLS

Disclosed herein is a process for the manufacture of (R)-phenylacetylcarbinol ((R)-PAC), (1R,2S). Ephedrine and its salts, (1R,2S)-norephedrine and its salts and 1-(Phenyl/Substituted phenyl)-2-(amino/alkylamino/dialklyamino) propan-1-ol and its salts, by enzymatic reduction of α-isonitrosopropiophenone (INP) and substituted α-isonitrosopropiophenone (substituted INP). The β-amino alcohols, produced by the process of present invention gives their corresponding diastereomers on Walden inversion. The present preparation process of (R)-PAC with (R)-PAC oxime as an intermediate has the advantage, that propiophenone as a key raw material which is easily available and has a low-price, operationally simple with high yield and a single process leading to the synthesis of several 1,2-aminoalcohol/ β- aminoalcohols active pharmaceutical ingredients. The design approach of the process is to reduce environmental impact of the product by comparing to the present manufacturing process.