55270-71-8

Usage

Chemical Properties

Solid

Preparation

Preparation by Fries rearrangement of phenyl o-chloro-benzoate in the presence of aluminium chloride, without solvent for 2 h at 160° or in nitrobenzene at 60° (31%).

InChI:InChI=1/C13H9ClO2/c14-11-7-3-1-5-9(11)13(16)10-6-2-4-8-12(10)15/h1-8,15H

Upstream product

• 41998-16-7 phenyl 2-chlorobenzoate 
• 1095-03-0 triphenylborane 
• 609-65-4 o-chlorobenzoyl chloride 
• 118-91-2 ortho-chlorobenzoic acid 
• 108-95-2 phenol 
• 100-66-3 methoxybenzene 
• 54118-74-0 2-chloro-4'-methoxybenzophenone 
• 104-92-7 1-bromo-4-methoxy-benzene 
• 89-98-5 2-chloro-benzaldehyde 
• 1174327-78-6 (2-chlorophenyl)(4-methoxyphenyl)methanol 

Downstream Products

• 83355-27-5 Acetic acid (2S,3R,4S,5R)-4,5-diacetoxy-2-[4-(2-chloro-benzoyl)-phenoxy]-tetrahydro-pyran-3-yl ester 
• 185606-03-5 (4-acetyloxyphenyl)-(2-chlorophenyl)-methanone 
• 83357-06-6 N-{(2S,3R,4R,5S,6R)-2-[4-(2-Chloro-benzoyl)-phenoxy]-4,5-dihydroxy-6-hydroxymethyl-tetrahydro-pyran-3-yl}-acetamide 
• 83354-73-8 (2-Chloro-phenyl)-[4-((2S,3R,4S,5R)-3,4,5-trihydroxy-tetrahydro-pyran-2-yloxy)-phenyl]-methanone 

Relevant academic research and scientific papers

Highly Enantioselective Cobalt-Catalyzed Hydroboration of Diaryl Ketones

A highly enantioselective cobalt-catalyzed hydroboration of diaryl ketones with pinacolborane was developed using chiral imidazole iminopyridine as a ligand to access chiral benzhydrols in good to excellent yields and ee. This protocol could be carried out in a gram scale under mild reaction conditions with good functional group tolerance. Chiral biologically active 3-substituted phthalide and (S)-neobenodine could be easily constructed through asymmetric hydroboration as a key step.

Synthesis and biological evaluation of negative allosteric modulators of the Kv11.1(hERG) channel

We synthesized and evaluated a series of compounds for their allosteric modulation at the Kv11.1 (hERG) channel. Most compounds were negative allosteric modulators of [3H]dofetilide binding to the channel, in particular 7f, 7h-j and 7p. Compounds 7f and 7p were the most potent negative allosteric modulators amongst all ligands, significantly increasing the dissociation rate of dofetilide in the radioligand kinetic binding assay, while remarkably reducing the affinities of dofetilide and astemizole in a competitive displacement assay. Additionally, both 7f and 7p displayed peculiar displacement characteristics with Hill coefficients significantly distinct from unity as shown by e.g., dofetilide, further indicative of their allosteric effects on dofetilide binding. Our findings in this investigation yielded several promising negative allosteric modulators for future functional and clinical research with respect to their antiarrhythmic propensities, either alone or in combination with known Kv11.1 blockers.

Synthesis and structure-activity relationships of benzophenone hydrazone derivatives with insecticidal activity

A broad range of benzophenone hydrazone derivatives was prepared and tested against selected chewing insect pests, allowing the analysis of structure-activity relationships. Good activity was found only when the aromatic rings were substituted at the 4-positions with an halogen atom and a triflate or perhaloalkoxy group. In contrast, a number of substituents on the hydrazone part led to active compounds, the best results being achieved with acyl-type substituents. The excellent laboratory and greenhouse activity of the best representatives was confirmed in semi-field trials against Spodoptera littoralis. ° 2001 Society of Chemical Industry.

Comparative study on the dynamics, polarity, and thermal properties of the isomers of (4-acetyloxyphenyl)-(chlorophenyl)-methanone

The effect of the location of the chlorine atoms on the dynamics, polarity, and thermal properties of the isomers derived from (4-acetyloxyphenyl)-(chlorophenyl)-methanone is discussed. The changes occurring in the dipole moments along the trajectories in

Process for ring acylation of phenols

Mono- and poly-phenols and derivatives thereof are ring acylated by a Friedel-Crafts acylation reaction in which the hydroxy groups are protected by prior silylation.