553-60-6

Usage

Uses

Used in Pharmaceutical Industry:
ISOPROPYL NICOTINATE is used as a vasodilator for improving blood circulation, which is beneficial in the treatment of conditions that involve poor blood flow to the skin or muscles.
Used in Cosmetic Industry:
ISOPROPYL NICOTINATE is used as an active ingredient in topical creams and gels for:
Treating cellulite: It helps in improving the appearance of the skin by enhancing blood flow to the affected areas.
Reducing the appearance of stretch marks: By promoting better blood circulation, it may aid in the healing process of the skin.
Diminishing wrinkles: The improved blood flow can contribute to the nourishment of the skin, potentially reducing the visibility of wrinkles.
Used as a Transdermal Enhancer:
ISOPROPYL NICOTINATE is used to increase the effectiveness of other active ingredients in topical formulations by facilitating their penetration through the skin, thus enhancing their overall therapeutic impact.

InChI:InChI=1/C9H11NO2/c1-7(2)12-9(11)8-4-3-5-10-6-8/h3-7H,1-2H3

Upstream product

• 59-67-6 nicotinic acid 
• 20260-53-1 pyridine-3-carbonyl chloride hydrochloride 
• 67-63-0 isopropyl alcohol 
• 75-30-9 2-iodo-propane 
• 100-54-9 pyridine-3-carbonitrile 

Downstream Products

• 59-67-6 nicotinic acid 
• 187737-37-7 propene 

Relevant academic research and scientific papers

N-alkylation of pyridylalanine and pyridinecarboxylic acids and their use in synthesis of GnRH antagonists

A mild N-alkylation method has been developed for the synthesis of N-alkylated pyridiniumcarboxylic acids, using Ag2O-H2O catalysis to enhance the low-reactivity of pyridinecarboxylic acids. Two approaches were undertaken for the synthesis of a series of GnRH antagonists containing pyridinium moieties at the side chain: (1) incorporation of Npy-alkylated D-pyridylalanine during solid phase peptide chain assembly, and (2) coupling of the N-alkylated pyridinium-carboxylic acid to the resin-bound ε-amino group of a D-lysine on a solid support.

Carbon monoxide is used as a source of halogen compound heterogeneous palladium catalyst in the presence of the aldehyde carbonyl compound by reaction carbonylation method (by machine translation)

[Problem] catalyst and the presence of carbon monoxide, the halogen compound is a carbonyl compound in the carbonylation reaction, catalysts or carbon monoxide source technique has problems. [Solution] the presence of the catalyst and the carbon monoxide, the halogen compound is carbonylation reaction method for producing a carbonyl compound, As a heterogeneous palladium catalyst, carbon monoxide is produced from an aldehyde carbonyl compound used in the method. [Drawing] no (by machine translation)

AMIDATION METHOD AND ESTERIFICATION METHOD USING SULFONIC ACID HALIDE

PROBLEM TO BE SOLVED: To provide a safe and economical method for rapidly synthesizing amides and esters in high yield. SOLUTION: There is provided a method for amidating an amine or a derivative thereof using a sulfonic acid halide, where a sulfonic acid halide is allowed to act as an activator on a carboxylic acid or a derivative thereof to synthesize an active ester, and the active ester is reacted with an amine or a derivative thereof as a nucleophile to amidate the amine or the derivative thereof to obtain a corresponding amide or a derivative thereof. In a similar manner, a sulfonic acid halide is allowed to act as an activator on a carboxylic acid or a derivative thereof to synthesize an active ester, and the active ester is reacted with an alcohol or a derivative thereof as a nucleophile to esterify the alcohol or the derivative thereof to obtain a corresponding ester or a derivative thereof. SELECTED DRAWING: Figure 1 COPYRIGHT: (C)2016,JPO&INPIT

Iron(III) chloride-promoted direct conversion of aryl/alkyl cyanides to esters

Aryl/alkyl cyanides were quickly converted into the corresponding esters in the presence of iron(III) chloride in refluxing alcohols with very good yields. Copyright Taylor & Francis Group, LLC.