55315-33-8 Usage
Thiazole derivative
A compound that is derived from the thiazole ring structure, which is a five-membered heterocyclic ring system containing sulfur and nitrogen atoms.
Benzodioxole ring
A chemical structure that consists of a benzene ring with two oxygen atoms attached to adjacent carbon atoms, creating a dioxide group (-O2).
Nitrogen atom attachment
The benzodioxole ring is attached to the nitrogen atom within the thiazole ring, forming a fused ring system.
Chloromethyl group
A chemical group consisting of a carbon atom bonded to a chlorine atom and a hydrogen atom (-CH2Cl).
4-position attachment
The chloromethyl group is attached to the 4th position of the thiazole ring, which is one of the five carbon atoms in the ring.
Potential biological activity
The compound may exhibit biological activity, meaning it could interact with biological systems and potentially produce pharmacological effects.
Research and pharmaceutical development
The compound may be used in scientific research and the development of new pharmaceuticals due to its potential biological activity.
Hazardous properties
The chemical may possess hazardous properties, making it potentially dangerous or harmful to handle.
Controlled laboratory setting
The compound should only be used by trained professionals in a controlled environment, such as a laboratory, to ensure proper handling and minimize risks.
Check Digit Verification of cas no
The CAS Registry Mumber 55315-33-8 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 5,5,3,1 and 5 respectively; the second part has 2 digits, 3 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 55315-33:
(7*5)+(6*5)+(5*3)+(4*1)+(3*5)+(2*3)+(1*3)=108
108 % 10 = 8
So 55315-33-8 is a valid CAS Registry Number.
55315-33-8Relevant academic research and scientific papers
Agonists for the adenosine A1 receptor with tunable residence time. a case for nonribose 4-amino-6-aryl-5-cyano-2-thiopyrimidines
Louvel, Julien,Guo, Dong,Agliardi, Marta,Mocking, Tamara A. M.,Kars, Roland,Pham, Tan Phát,Xia, Lizi,De Vries, Henk,Brussee, Johannes,Heitman, Laura H.,Ijzerman, Adriaan P.
, p. 3213 - 3222 (2014/05/20)
We report the synthesis and evaluation of previously unreported 4-amino-6-aryl-5-cyano-2-thiopyrimidines as selective human adenosine A 1 receptor (hA1AR) agonists with tunable binding kinetics, this without affecting their nanomolar affinity for the target receptor. They show a very diverse range of kinetic profiles (from 1 min (compound 52) to 1 h (compound 43)), and their structure-affinity relationships (SAR) and structure-kinetics relationships (SKR) were established. When put in perspective with the increasing importance of binding kinetics in drug discovery, these results bring new evidence of the consequences of affinity-only driven selection of drug candidates, that is, the potential elimination of slightly less active compounds that may display preferable binding kinetics.
