55385-49-4Relevant academic research and scientific papers
A containing halogen light active 2 - oxo - 1, 3 - oxazine compounds and its preparation method and application
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, (2017/08/23)
The invention discloses a 2-carbonyl-1,3-oxazine compound and a preparation method therefor and application thereof. The structural formula of the 2-carbonyl-1,3-oxazine compound is shown in a formula II. The preparation method comprises: carrying out a reaction on a compound shown in a formula I and N-bromoacetamide (or 1,3-dibromo-5,5-dimethyl hydantoin) under the action of a scandium trifluoromethanesulfonate/monophosphine ligand. The photoactive 2-carbonyl-1,3-oxazine compound provided by the invention can be used for conveniently obtaining compounds containing 1,3-hydroxylamine structures and functionalized heterocyclic compounds through further conversion reactions, and meanwhile, a bromine atom can be introduced into the reaction. The functional groups can be further converted. Other functional groups are introduced, so that the compound has huge application value. According to the method provided by the invention, raw materials are easily synthesized, the reaction condition is mild, the operation is simple and convenient, the region selectivity is high, the enantioselectivty can reach up to over 99%, and the output reaches up to 72%. The formulae are shown in the description.
Intramolecular Kulinkovich-de Meijere reactions of various disubstituted alkenes bearing amide groups
Madelaine, Claire,Ouhamou, Nouara,Chiaroni, Angèle,Vedrenne, Emeline,Grimaud, Laurence,Six, Yvan
, p. 8878 - 8898 (2008/12/21)
A range of amides fitted with (E) or (Z) disubstituted alkene groups were prepared and evaluated in intramolecular Kulinkovich-de Meijere reactions. The corresponding aminocyclopropanes were obtained with high diastereoselectivity. Good yields could be achieved with substrates bearing suitable substitutions at the olefin moieties.
