2044-73-7Relevant academic research and scientific papers
Spin Crossover vs. High-Spin Iron(II) Complexes in N4S2 Coordination Sphere Containing Picolyl-Thioether Ligands and NCE (E=S, Se and BH3) Co-Ligands
Plaza-Lozano, Diego,Conde-Gallardo, Agustín,Olguín, Juan
, p. 2846 - 2856 (2021)
To study the effect of the chelate ring size on the magnetic properties of thioether-based iron(II) metal complexes, two ligands have been envisaged, synthesised and characterised. The two ligands correspond to the bidentate benzylpicolylthioether (PySBn) and tetradentate 2,3-bis(((2-pyridylmethyl)thio)methyl)quinoxaline (QuinoxS). Five iron(II) complexes have been synthesised, containing either two bidentate ligands or one tetradentate ligand, and two N-bond NCE co-ligands (E=S, Se or BH3): trans-[FeII(PySBn)2(NCE)2] (1 a–b) and cis-[FeII(QuinoxS)(NCE)2] (2 a–c), a for E=S, b for E=Se and c for E=BH3. The iron(II) complexes have been characterised by standard techniques, X-ray crystallography (except for complex 1 a) and VT-magnetic measurements in the solid state. X-ray crystallography showed that all the complexes are isolated in the high spin (HS) state, based on the relatively long Fe?L bond lengths, Fe?N>2.0 ? and Fe?S≈2.5–2.6 ?. VT-magnetic measurements demonstrated that complexes 1 a and 2 a-c are stabilised in the HS-state, showing orbital contribution to g and zero field splitting. However, complexes 1 b shows a relatively abrupt, hysteretic, and incomplete at the low-end spin conversion, with T1/2↓=92, T1/2↑=98 K and ΔT1/2=6 K at 5 K min?1, moreover, the hysteresis loop is scan rate dependent increasing up to 11 K at 10 K min?1. An analysis of structural and electronic parameters has been performed to rationalise the differing magnetic properties of the metal complexes, such as metallacycle size, bond lengths and angles, and cis- vs. trans-coordination mode. A comparison with the literature-reported spin crossover iron(II) complexes in N4S2 coordination sphere containing NCE co-ligands has been conducted as well, finding that, as previously reported, the Fe?N?C(E) bond angle is diagnostic for determining the spin lability of the metal complexes, and in addition we have found that the N?C(E) bond length is too useful.
Fluorescent molecule for recognizing copper ions, preparation method and application
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Paragraph 0099; 0108; 0109; 0110, (2019/02/04)
The invention discloses a fluorescent molecule for recognizing copper ions, a preparation method and application. Polycyclic aromatic hydrocarbons such as naphthalene rings or anthracene rings are used as initial raw materials; through a series of optimized organic synthesis reaction (substitution and addition), after the connection with different recognition sites, molecular clamp body tweezer host compounds with different recognition performance can be obtained. The fluorescent molecule can be used for copper ion detection and solves the problems that the existing molecule device is difficult to effectively recognize object molecules.
Fluorescent molecule for identifying mercury ions as well as preparation method and application
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Paragraph 0108; 0110; 0111; 0112, (2019/01/08)
The invention discloses a fluorescent molecule for identifying mercury ions as well as a preparation method and application. Polycyclic aromatic hydrocarbons including a naphthalene ring or an anthracene ring and the like are used as starting raw materials and different identification sites are connected through a series of organic synthetic reaction (including substitution and addition) to obtainmolecular-tweezers-shaped main body compounds with different identification properties. The fluorescent molecule can be used for detecting the mercury ions and the problem that guest molecules cannotbe easily effectively identified through an existing molecule device is solved.
The reactions of pyridinyl thioesters with triiron dodecacarbonyl: Their novel diiron carbonyl complexes and mechanistic investigations
Long, Li,Xiao, Zhiyin,Zampella, Giuseppe,Wei, Zhenhong,De Gioia, Luca,Liu, Xiaoming
, p. 9482 - 9492 (2012/09/05)
Reaction of Fe3(CO)12 with pyridinyl thioester ligand PyCH2SCOCH3 (L1, Py = pyridin-2-yl) produced complex, [Fe2(κ-COCH3)(μ-SCH2Py)(CO) 5] (1) (PyCH2S = pyridin-2-ylmethanethiolate). When complex 1 reacted with PPh3, a monosubstituted complex, [Fe 2(κ-COCH3)(μ-SCH2Py)(CO) 4PPh3] (2), was derived. Reaction of the same precursor with analogous thioester ligand PyCH2SCOPy (L2) generated three novel diiron complexes, [Fe2(κ-Py)(μ-SCH 2Py)(CO)5] (3), [Fe2(κ-Py)′(μ- SCH2Py)(CO)5] (4), and [Fe2(κ-Py)(μ- SCH2Py)(CO)6] (5). Complexes 3 and 4 are structural isomers. Complex 5 could be converted into complex 4 but the conversion from complex 5 to the isomer 3 was not observed. All the five complexes were fully characterised using FTIR, NMR, and other techniques. Their structures were determined using X-ray single crystal diffraction analysis. The oxidative formation of complexes 1, 3, 4, and 5 involved C-S and/or C-C bonds cleavages. To probe possible mechanisms for these cleavages, DFT calculations were performed. From the calculations, viable reaction pathways leading to the formation of all the isolated products were delineated. The results of the theoretic calculations also allowed rationalisation of the experimental observations.
4-(Pyridin-2-yl)thiazol-2-yl thioglycosides as bidentate ligands for oligosaccharide synthesis via temporary deactivation
Pornsuriyasak, Papapida,Rath, Nigam P.,Demchenko, Alexei V.
supporting information; experimental part, p. 5633 - 5635 (2009/04/13)
This study focusses on a new concept for oligosaccharide synthesis based on 4-(pyridin-2-yl)thiazol-2-yl thioglycosides that can either act as effective glycosyl donors or can be deactivated by stable bidentate complexation with palladium(ii) bromide. The Royal Society of Chemistry.
Complexation and (templated) synthesis of rhenium complexes with cyclodextrins and cyclodextrin dimers in water
Van Bommel, Kjeld J. C.,De Jong, Menno R.,Metselaar, Gerald A.,Verboom, Willem,Huskens, Jurriaan,Hulst, Ron,Kooijman, Huub,Spek, Anthony L.,Reinhoudt, David N.
, p. 3603 - 3615 (2007/10/03)
Several small, lipophilic rhenium complexes form inclusion complexes with native β-cyclodextrin (β-CD) and β-CD dimers. Association constants larger than 109M-1 were obtained using dimers. The use of β-CD also enabled the synthesis of these rhenium complexes in water, in excellent yields, through complexation of the otherwise insoluble corresponding ligands. The influence of the reaction time and temperature on the configuration of the reaction products has been investigated in depth for one of these complexes. Using a β-CD dimer, it proved possible to specifically template the formation of one configuration. The strength of the complexes of the rhenium complexes in cyclodextrin dimers may allow radiolabeling of biomolecules.
Inhibition of human cytomegalovirus protease N(o) with monocyclic β- lactams
Deziel,Malenfant
, p. 1437 - 1442 (2007/10/03)
Monocyclic β-lactams have been identified as potent and selective inhibitors of the human cytomegalovirus protease (HCMV) N(o). Two series of these inhibitors are described, a peptidyl series of compounds and non- peptidic molecules featuring lower molecular weights. The SAR work that lead to the discovery of these inhibitors, together with their synthesis is also disclosed.
PENEM DERIVATIVES AND ANTIMICROBIAL AGENT CONTAINING THE SAME
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, (2008/06/13)
A penem derivative represented by the following formula (I): wherein R1represents a substituted or unsubstituted alkyl group, a substituted or unsubstituted alkenyl group, a substituted or unsubstituted aralkyl group, a substituted or unsubstituted aryl group, a substituted or unsubstituted alkylthio group, a substituted or unsubstituted alkenylthio group, a substituted or unsubstituted aralkylthio group, a substituted or unsubstituted arylthio group, a substituted or unsubstituted heterocyclic group, a substituted or unsubstituted heterocyclic thio group, a substituted or unsubstituted acylthio group, a mercapto group or a hydrogen atom, and R2represents a hydrogen atom or a carboxyl-protecting group; or a pharmacologically acceptable salt thereof. The compound (I) exhibits strong antibacterial activities, and especially, shows strong activities against MRSA. It is therefore useful not only as a general antibacterial agent but also as an antibacterial agent for MRSA against which no general antibacterial agents are recognized to be effective.
A new strategy for the synthesis of phosphorothioates of 2′-deoxyriboligonucleotides
Kumar, Prabhat,Misra
, p. 1000 - 1004 (2007/10/03)
2-Picoline thiol, a new reagent, has been indigenously prepared and a new strategy has been followed for the sulphurization of phosphate bond in nucleotide monomer. The 2-picolylthiophosphorobis-(triazolide) has been prepared using phosphite triester approach and treated with protected nucleosides to get phosphorothioate synthons. The two dimers, d(GpT) and d(TpT) have been synthesised in very good yields using these synthons. The removal of 2-methylpyridyl group at the end of synthesis is achieved with 1,1,3,3-tetramethylguanidinium-4-nitrobenzaldoxime in dioxane-water.
