55415-32-2

Usage

Chemical structure

A benzimidazole derivative with a benzyl group, a chlorine atom, and a methyl group attached to the benzimidazole ring

Pharmacological significance

Contains a benzimidazole moiety, which is commonly found in various pharmaceuticals

Potential applications

Anthelmintic, antibacterial, and antifungal agents

Exploration and characterization

Its specific properties and potential uses in medicinal chemistry and drug discovery remain to be fully explored and characterized
Please note that this list is based on the provided material and may not be exhaustive. Further research and analysis would be required to fully understand the properties and potential applications of 1-benzyl-2-chloro-5-methyl-1H-benzimidazole.

Upstream product

• 28643-35-8 1-benzyl-5-methyl-1,3-dihydro-2H-benzo[d]imidazol-2-one 
• 22019-66-5 4-methyl-2-nitro-N-benzylaniline 
• 39235-93-3 N¹-benzyl-4-methylbenzene-1,2-diamine 
• 100-39-0 benzyl bromide 
• 89-62-3 4-methyl-2-nitroaniline 

Relevant academic research and scientific papers

New 2-piperazinylbenzimidazole derivatives as 5-HT3 antagonists. Synthesis and pharmacological evaluation

A series of 2-piperazinylbenzimidazole derivatives were prepared and evaluated as 5-HT3 receptor antagonists. Their 5-HT3 receptor affinities were evaluated by radioligand binding assays, and their abilities to inhibit the 5-HT-induced Bezold-Jarisch reflex in anesthetized rats were determined. Compound 7e (lerisetron, pK(i) = 9.2) exhibited higher affinity for the 5- HT3 receptor than did tropisetron and granisetron, while compound 7q (pK(i) = 7.5) had very low affinity for this receptor, showing that substitution on the N1 atom of the benzimidazole ring is essential for affinity and activity. The effect of substitution on the aromatic ring of benzimidazole by several substituents in different positions is also discussed. A strong correlation between the 5-HT3 antagonistic activity of the studied compounds and the position of substitution on the aromatic ring was established. Thus, while the 4-methoxy derivative 7m showed weak affinity for the 5-HT3 receptor (pK(i) = 6.7), the 7-methoxy derivative 7n exhibited the highest affinity (pK(i) = 9.4). Compounds 7e and 7n are now under further investigation as drugs for the treatment of nausea and emesis evoked by cancer chemotherapy and radiation.