55420-71-8

Upstream product

• 83-38-5 2,6-dichlorobenzaldehyde 
• 78-95-5 chloroacetone 
• 67-64-1 acetone 

Downstream Products

• 84175-36-0 1-(2,6-dichlorophenyl)-5-(4-morpholinyl)-1-penten-3-one hydrochloride 
• 736150-32-6 4-[(E)-5-(2,6-dichlorophenyl)-3-oxopent-4-enoyl]piperidine-1-carboxylic acid tert-butyl ester 
• 721428-84-8 4-{5-[2-(2,6-dichloro-phenyl)-vinyl]-1H-pyrazol-3-yl}-piperidine-1-carboxylic acid tert-butyl ester 
• 1353042-42-8 (E)-ethyl 6-(2,6-dichlorophenyl)-2-hydroxy-4-oxohex-5-enoate 
• 1345200-89-6 (2'R,3'R,6'S,7S,11R)-7-(2,6-dichlorophenyl)-11-(2,3-dimethoxy-2,3-dimethyl-[1,4]dioxan-6-yl)-2,4-dimethyl-2,4-diazaspiro[5.5]undecane-1,3,5,9-tetraone 
• 721428-85-9 4-{1-(3-chloro-phenyl)-5-[2-(2,6-dichloro-phenyl)-vinyl]-1H-pyrazol-3-yl}-piperidine-1-carboxylic acid tert-butyl ester 

Relevant academic research and scientific papers

Dehydrozingerone Inspired Discovery of Potential Broad-Spectrum Fungicidal Agents as Ergosterol Biosynthesis Inhibitors

A series of dehydrozingerone derivatives were synthesized, and their fungicidal activities and action mechanism against Colletotrichum musae were evaluated. The bioassay result showed that most compounds exhibited excellent fungicidal activity in vitro at 50 μg mL-1. Compounds 13, 16, 18, 19, and 27 exhibited broad-spectrum fungicidal activity; especially, compounds 19 and 27 were found to have more potent fungicidal activity than azoxystrobin. The EC50 values of compounds 19 and 27 against Rhizoctonia solani were 0.943 and 0.161 μg mL-1 respectively. Moreover, compound 27 exhibited significant in vitro bactericidal activity against Xanthomonas oryzae pv. oryzae, with an EC50 value of 11.386 μg mL-1, and its curative effect (49.64%) and protection effect (51.74%) on rice bacterial blight disease was equivalent to that of zhongshengmycin (42.90%, 40.80% respectively). Compound 27 could also effectively control gray mold (87.10%, 200 μg mL-1) and rice sheath blight (100%, 200 μg mL-1 82.89%, 100 μg mL-1) in vivo. Preliminary action mechanism study showed that compound 27 mainly acted on the cell membrane and significantly inhibited ergosterol biosynthesis in Colletotrichum musae.

NOVEL MICROBIOCIDES

Compounds of formula (I), in which the substituents are as defined in claim 1, are suitable for use as microbiocides.

NOVEL MICROBIOCIDES

Compounds of formula (I), in which the substituents are as defined in claim 1, are suitable for use as microbiocides.

Chromatography-free wittig reactions using a bifunctional polymeric reagent

The first example of a polystyrene bearing two distinct reagent groups has been prepared. This phosphine and amine functionalized material was used in one-pot Wittig reactions with an aldehyde and either an α-halo-ester, -ketone, or -amide. Due to the heterogeneous nature of the polymer, the desired alkene product of these reactions could be isolated in excellent yield in essentially pure form after only filtration and solvent removal.

SUBSTITUTED DIHYDROPYRIDINES AND METHODS OF USE

Compounds are provided that are modulators of the C5a receptor. The compounds are substituted dihydropyridines and are useful in pharmaceutical compositions, methods for the treatment of diseases and disorders involving the pathologic activtation of C5a receptors.

Synthesis and antibacterial activity of a novel series of DNA gyrase inhibitors: 5-[(E)-2-arylvinyl]pyrazoles

The 2-arylvinyl moiety in 1-(3-chlorophenyl)-3-(4-piperidyl)-5-[(E)-2-(5- chloro-1H-indol-3-yl)vinyl]pyrazole 2, which has previously shown improved DNA gyrase inhibition and target-related antibacterial activity, was transformed to other groups and the i

Unsaturated oxime ethers and their use as fungicides

The present invention relates to certain oxime ether compounds, compositions containing these compounds, and methods for controlling fungi by the use of a fungitoxic amount of the compounds or compositions.

Mannich Bases of 4-Phenyl-3-buten-2-one: A New Class of Antiherpes Agent

The morpholine Mannich base of 4-phenyl-3-buten-2-one was found to have activity in model infections of herpes simplex.The activity was essentially equivalent to that of disodium phosphonoacetate.This paper presents the biological activity and synthesis o

Antiviral 1-aryl-5-amino-1-penten-3-ones

Compounds of the formula STR1 wherein R is H, halo, C1-4 alkyl, C1-4 alkoxy, 3,4-methylenedioxy, CF3, NO2, NH2, N(C1-4 alkyl)2, CN, OH, --S(C1-4 alkyl) or --SO2/