55483-71-1

Upstream product

• 94-71-3 2-Ethoxyphenol 
• 88331-63-9 2-ethoxy-4-nitroso-phenol 
• 55483-70-0 3-ethoxy-4-hydroxyaniline 
• 87-13-8 diethyl 2-ethoxymethylenemalonate 

Downstream Products

• 1190363-99-5 C₂₃H₂₅Cl₂NO₆ 
• 1190363-96-2 C₂₃H₂₆ClNO₆ 
• 1190363-94-0 C₂₃H₂₆ClNO₆ 
• 1190364-01-2 C₂₄H₂₉NO₇ 
• 1190364-03-4 C₂₃H₂₄F₃NO₆ 
• 26692-07-9 2-[(4-decyloxy-3-ethoxy-phenylamino)-methylene]-malonic acid diethyl ester 

Relevant academic research and scientific papers

Synthetic method of decoquinate

The invention discloses a synthetic method of decoquinate, and belongs to the technical field of pharmaceutical engineering. The synthetic method takes o-hydroxyphenyl ethyl ether as a raw material to prepare decoquinate via the processes of coupling, reduction, condensation, etherification, cyclization and the like. The process of reduction in the method adopts environment-friendly hydrazine hydrate as a reducer to reduce an azo-compound and introduce an amino group, so that the synthetic method is good in selectivity, and environmentally friendly, and beneficial for reducing environmental pollution problems; BTC is adopted as a cyclization reagent in the process of cyclization, so that the condition is mild, the requirement on equipment is lowered, and the cost is reduced.

Preparation method of decoquinate

The invention discloses a preparation method of decoquinate. Industrialized 2-hydroxyphenylacetic acid phenetole serves as starting materials, and a product with better quality is obtained through diazo coupling, sodium dithionite reduction, condensation, etherificationa and superstrong solid acid SO4/Fe2O3 and sodium bisulfate cyclization. Part intermediate of a synthetic route of the decoquinate does not need to be purified, used solvent is single, aftertreatment of the intermediate and use of organic solvent are reduced, the cost is reduced, the whole process route is short, extremely high temperature or highly corrosive liquid acid is not needed, requirement to equipment is low, operation is easy and convenient, the production cycle is short, produced three wastes are fewer, the production yield is high, the quality is good, and the preparation method of the decoquinate is suitable for industrial production.

Synthesis and anticoccidial activities of Quinoline Carboxylate derivatives with Methyl (E)-2-(3-methoxy)acrylate moiety

A series of novel quinoline carboxylate derivatives with methyl (E)-2-(3-methoxy) acrylate group were designed and synthesized as anticoccidial medicines. The structures were confirmed by 1H NMR, IR and HR-MS spectra. The biological activities were primarily evaluated according to the anticoccidial index method. The results indicated that these compounds (7c, 7d, 7e, 7g) exhibited anticoccidial activities against Eimeria tenella. In particular, the anticoccidial index of 6-decyloxy-7-ethoxy-4-{6-[2-(2-methoxy-1-methoxycarbonyl- vinyl)phenoxy]pyrimidin-4-yloxy}- quinoline-3-carboxylic acid ethyl ester (7e) was 168.7, which indicated that the compound has a good anticoccidial activity.

Synthesis and anticoccidial activity of ethyl 6-substitutedbenzyloxy-7- alkoxy-4-hydroxyquinoline-3-carboxylates

A series of novel ethyl 6-substitutedbenzyloxy-7-alkoxy-4-hydroxyquinoline- 3-carboxylates have been designed and synthesised from 4-nitro-2-alkoxyphenol. Their structures have been characterised by 1H NMR, HRMS and IR spectra. Anticoccidial activities of