73908-30-2

Basic information

• Product Name: (-)-(R)-2-Pyridylethylene oxide
• Synonyms: (-)-(R)-2-Pyridylethylene oxide
• CAS NO: 73908-30-2
• Molecular Weight: 121.139
• Mol File: 73908-30-2.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: (-)-(R)-2-Pyridylethylene oxide(CAS DataBase Reference)
• NIST Chemistry Reference: (-)-(R)-2-Pyridylethylene oxide(73908-30-2)
• EPA Substance Registry System: (-)-(R)-2-Pyridylethylene oxide(73908-30-2)

Safety Data

• Hazardous Substances Data: 73908-30-2(Hazardous Substances Data)

Upstream product

• 769140-90-1 (R)-2-(1-hydroxy-2-chloroethyl)-pyridine 
• 109-04-6 2-bromo-pyridine 
• 55484-10-1 2-chloro-1-(pyridin-2-yl)ethanone 
• 55967-94-7 2-oxiranylpyridine 
• 100-69-6 2-vinylpyridine 
• 55967-97-0 2-bromo-1-(pyridin-2-yl)ethan-1-ol 
• 40086-66-6 2-Bromoacetylpyridine 
• 73951-61-8 (R)-2-bromo-1-(pyridin-2-yl)ethan-1-ol 

Downstream Products

• 1251957-71-7 2-[4-(2-{[(2S)-2-hydroxy-2-(pyridin-2-yl)ethyl]amino}-2-methylpropyl)phenyl]-N-(5-methylisoxazol-3-yl)acetamide 

Relevant articles and documents

Azidolysis of epoxides catalysed by the halohydrin dehalogenase from Arthrobacter sp. AD2 and a mutant with enhanced enantioselectivity: an (S)-selective HHDH

Halohydrin dehalogenase from Arthrobacter sp. AD2 catalysed azidolysis of epoxides with high regioselectivity and low to moderate (S)-enantioselectivity (E?=?1–16). Mutation of the asparagine 178 to alanine (N178A) showed increased enantioselectivity towards styrene oxide derivatives and glycidyl ethers. Conversion of aromatic epoxides was catalysed by HheA-N178A with complete enantioselectivity, however the regioselectivity was reduced. As a result of the enzyme-catalysed reaction, enantiomerically pure (S)-β-azido alcohols and (R)-α-azido alcohols (ee???99%) were obtained.

DNA-based hydrolytic kinetic resolution of epoxides

DNA-bound copper(II) complexes serve as catalysts for the hydrolytic kinetic resolution of 2-pyridyloxiranes in water. Selectivity factors of up to 2.7 were achieved, indicating a chirality transfer of DNA to epoxides via a coordinated metal ion.

Product Stereospecificity in the Microbial Reduction of α-Haloaryl Ketones

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