55484-11-2

Usage

Uses

Used in Chemical Synthesis:
Ethanone, 2-chloro-1-(3-pyridinyl)(9CI) is used as a key intermediate in the synthesis of various organic compounds. Its unique structure allows for the creation of a wide range of chemical products, making it a valuable component in the field of organic chemistry.
Used in Pharmaceutical Research:
Ethanone, 2-chloro-1-(3-pyridinyl)(9CI) is used as a building block in the development of potential therapeutic agents. Its presence in the molecular structure of certain compounds can contribute to their pharmacological properties, such as their ability to interact with biological targets and exhibit therapeutic effects.
Used in Material Science:
Ethanone, 2-chloro-1-(3-pyridinyl)(9CI) may also be employed in the development of new materials with specific properties. Its incorporation into the molecular structure of materials can lead to the creation of compounds with unique characteristics, such as improved stability or enhanced reactivity, which can be beneficial in various applications within material science.

InChI:InChI=1/C7H6ClNO/c8-4-7(10)6-2-1-3-9-5-6/h1-3,5H,4H2

Upstream product

• 61889-48-3 2-chloro-1-(3-pyridinyl)ethanone hydrochloride 
• 39972-50-4 2-diazo-1-(pyridine-3-yl)ethan-1-one 
• 350-03-8 methyl-3-pyridylketone 

Downstream Products

• 373359-48-9 2-dibenzylamino-1-pyridin-3-yl-ethanol 
• 173901-03-6 (R)-2-chloro-1-(3-pyridyl)-ethanol 
• 515179-33-6 (S)-2-chloro-1-(pyridin-3-yl)ethanol 
• 373359-47-8 2-dibenzylamino-1-pyridin-3-yl-ethanone 
• 61889-56-3 (4-chloro-phenyl)-(4-pyridin-3-yl-thiazol-2-yl)-amine 
• 61889-59-6 benzyl-(4-pyridin-3-yl-thiazol-2-yl)-amine 
• 61889-49-4 N-phenyl-4-(3-pyridinyl)-1,3-thiazol-2-amine 
• 61889-50-7 (2-methoxy-phenyl)-(4-pyridin-3-yl-thiazol-2-yl)-amine 
• 61889-51-8 (4-methoxy-phenyl)-(4-pyridin-3-yl-thiazol-2-yl)-amine 
• 30235-27-9 4-(pyridin-3-yl)thiazol-2-amine 
• 104501-59-9 3-Hydroxyacetylpyridine 

Relevant academic research and scientific papers

Dichloroacetophenones targeting at pyruvate dehydrogenase kinase 1 with improved selectivity and antiproliferative activity: Synthesis and structure-activity relationships

Dichloroacetophenone is a pyruvate dehydrogenase kinase 1 (PDK1) inhibitor with suboptimal kinase selectivity. Herein, we report the synthesis and biological evaluation of a series of novel dichloroacetophenones. Structure-activity relationship analyses (SARs) enabled us to identify three potent compounds, namely 54, 55, and 64, which inhibited PDK1 function, activated pyruvate dehydrogenase complex, and reduced the proliferation of NCI-H1975 cells. Mitochondrial bioenergetics assay suggested that 54, 55, and 64 enhanced the oxidative phosphorylation in cancer cells, which might contribute to the observed anti-proliferation effects. Collectively, these results suggested that 54, 55, and 64 could be promising compounds for the development of potent PDK1 inhibitors.

A scalable asymmetric synthesis of (R)-2-amino-1-(3-pyridinyl)ethanol dihydrochloride via an oxazaborolidine catalyzed borane reduction

This report describes a scalable process for the asymmetric synthesis of (R)-2-amino-1-(3-pyridinyl)ethanol dihydrochloride. The stereochemistry of the product is set via a reduction of 3-chloroacetyl pyridine with 2 equiv of borane-dimethyl sulfide and a catalytic amount of an in situ generated oxazaborolidine. The enantiomeric excess (ee) of the reductive step depends on the addition rate of the substrate and the temperature. The authors hypothesize that the low ee observed during a fast addition of the substrate or at low temperatures is due to the slow regeneration of the active catalyst from the catalyst-product complex.