30235-27-9

Basic information

• Product Name: 4-PYRIDIN-3-YL-THIAZOL-2-YLAMINE
• Synonyms: 2-AMINO-4-(3-PYRIDYL)THIAZOLE;4-PYRIDIN-3-YL-THIAZOL-2-YLAMINE;4-(3-PYRIDINYL)-1,3-THIAZOL-2-YLAMINE;BUTTPARK 33\12-84;IFLAB-BB F0537-0970;TIMTEC-BB SBB010098;4-(3-PYRIDINYL)-2-THIAZOLAMINE;4-pyridine-3-yl-thiazol-2-ylamine
• CAS NO: 30235-27-9
• Molecular Formula: C₈H₇N₃S
• Molecular Weight: 177.23
• Mol File: 30235-27-9.mol
• Article Data: 18

Chemical Properties

• Melting Point: 213 °C(Solv: ethanol (64-17-5))
• Boiling Point: 396.3 °C at 760 mmHg
• Flash Point: 193.5 °C
• Appearance: Pale brown/Solid
• Density: 1.333 g/cm³
• Vapor Pressure: 1.72E-06mmHg at 25°C
• Refractive Index: 1.669
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• PKA: 3.33±0.10(Predicted)
• CAS DataBase Reference: 4-PYRIDIN-3-YL-THIAZOL-2-YLAMINE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-PYRIDIN-3-YL-THIAZOL-2-YLAMINE(30235-27-9)
• EPA Substance Registry System: 4-PYRIDIN-3-YL-THIAZOL-2-YLAMINE(30235-27-9)

Safety Data

• Hazard Codes: Xi
• Hazardous Substances Data: 30235-27-9(Hazardous Substances Data)

Usage

Uses

It is used as a pharmaceutical intermediate.

InChI:InChI=1/C8H7N3S/c9-8-11-7(5-12-8)6-2-1-3-10-4-6/h1-5H,(H2,9,11)

Upstream product

• 55484-11-2 2-chloro-1-(pyridin-3-yl)ethan-1-one 
• 17356-08-0 thiourea 
• 6221-12-1 3-Bromoacetylpyridine 
• 350-03-8 methyl-3-pyridylketone 
• 144-55-8 sodium hydrogencarbonate 
• 1147550-11-5 ammonium thiocyanate 
• 2510-23-8 3-Ethynylpyridine 
• 502145-18-8 4-bromo-1,3-thiazol-2-amine 
• 1692-25-7 3-pyridylboronic acid 
• 17694-68-7 3-(2-bromoacetyl)pyridine hydrobromide 

Downstream Products

• 108351-90-2 4-(1,2,5,6-tetrahydro-1-propyl-3-pyridinyl)-2-thiazolamine 
• 139420-57-8 2-Hydrazino-4-(3'-pyridyl)thiazole 

Relevant articles and documents

Design, synthesis and biological evaluation of 4-aryl-5-aminoalkyl-thiazole-2-amines derivatives as ROCK II inhibitors

A series of 4-aryl-5-aminoalkyl-thiazole-2-amines were designed and synthesized, and their inhibitory activity on ROCK II was screened by enzyme-linked immunosorbent assay (ELISA). The results showed that 4-aryl-5-aminomethyl-thiazole-2-amines derivatives had certain ROCK II inhibitory activities. Compound 10l showed ROCK II inhibitory activity with IC50 value of 20 nM.

Aiding the versatility of simple ammonium ionic liquids by the synthesis of bioactive 1,2,3,4-tetrahydropyrimidine, 2-aminothiazole and quinazolinone derivatives

Simple ammonium ionic liquids [ILs] are efficient, green, environmentally friendly catalysts in promoting the Biginelli condensation reaction, Hantzsch reaction and Niementowski reaction to afford 1,2,3,4-tetrahydropyrimidine, 2-aminothiazole and quinazolinone derivatives respectively by eliminating the need for harmful volatile organic solvents. These [ILs] are air and water stable, easy to prepare and cost-effective. The effects of the anions and cations present in [IL] on reactions were investigated. The results clearly indicated that the Biginelli condensation reaction, Hantzsch reaction and Niementowski reaction were heavily influenced by the acidity of [IL], and among various ammonium ionic liquids, [Et3NH][HSO4] showed the best catalytic activity. Furthermore, [IL] could be easily separated and reused with a slight loss of its activity. This technique provided a good alternative way for the industrial synthesis of 1,2,3,4-tetrahydropyrimidinones, 2-aminothiazoles and quinazolinones. The present processes are eco-friendly methods for the synthesis of these derivatives authenticated by several green parameters, namely,E-factor, process mass intensity, reaction mass efficiency, atom economy, and carbon efficiency.

Design, synthesis, and biological evaluation of urea-based ROCK2 inhibitors

A series of urea-based ROCK2 inhibitors were design and synthesized. The inhibitory activity on ROCK2 was screened by enzyme-linked immunosorbent assay (ELISA). The study results showed that the urea derivatives exhibited certain ROCK2 inhibitory activity. The most potent compound 10p showed ROCK2 inhibitory activity with the IC50?value of 0.03?μM. A preliminary structure-activity relationship was then summarized. The molecular docking studies showed that further optimization needs to conduct to obtain more potent ROCK inhibitors.