5554-58-5

Basic information

• Product Name: 1,3-dimethyl-2,6-diphenylpiperidin-4-one
• Synonyms: 1,3-Dimethyl-2,6-diphenylpiperidin-4-one; 1,3-Dimethyl-2,6-diphenyl-piperidin-4-one; 4-Piperidinone, 1,3-dimethyl-2,6-diphenyl-
• CAS NO: 5554-58-5
• Molecular Formula: C₁₉H₂₁NO
• Molecular Weight: 279.3761
• Mol File: 5554-58-5.mol
• Article Data: 22

Chemical Properties

• Boiling Point: 416°C at 760 mmHg
• Flash Point: 192.8°C
• Density: 1.064g/cm³
• Vapor Pressure: 3.97E-07mmHg at 25°C
• Refractive Index: 1.561
• CAS DataBase Reference: 1,3-dimethyl-2,6-diphenylpiperidin-4-one(CAS DataBase Reference)
• NIST Chemistry Reference: 1,3-dimethyl-2,6-diphenylpiperidin-4-one(5554-58-5)
• EPA Substance Registry System: 1,3-dimethyl-2,6-diphenylpiperidin-4-one(5554-58-5)

Safety Data

• Hazardous Substances Data: 5554-58-5(Hazardous Substances Data)

Usage

General Description

1,3-dimethyl-2,6-diphenylpiperidin-4-one, also known as MDPK, is a synthetic chemical compound belonging to the piperidine class. It is a psychoactive substance that acts as a stimulant and has been reported to produce effects similar to those of amphetamines. MDPK is often sold as a designer drug and is used recreationally for its euphoric and energizing effects. The compound is structurally related to other piperidine derivatives like MDPV, and its long-term effects and potential for addiction and abuse are not well understood. MDPK is considered a controlled substance in many countries due to its potential for misuse and adverse health effects.

Upstream product

• 100-52-7 benzaldehyde 
• 74-89-5 methylamine 
• 78-93-3 butanone 
• 5554-57-4 cis-2,6-diphenyl-trans-3-methylpiperidin-4-one 
• 74-88-4 methyl iodide 
• 87961-20-4 C₁₉H₂₂⁽²⁾HNO 
• 87961-20-4 C₁₉H₂₂⁽²⁾HNO 
• 37418-38-5 VUF₁₄₁₆₁ 
• 861882-13-5 C₂₀H₂₄N₄S 
• 79-04-9 chloroacetyl chloride 
• 5554-57-4 3e-methyl-2e,6e-diphenyl-4-piperidone 
• 14164-67-1 (1E,4E)-2-methyl-1,5-diphenylpenta-1,4-dien-3-one 
• 19340-09-1 t-2,t-6-diphenyl-c-3,N-dimethylpiperidin-r-4-ol 
• 19340-09-1 c-2,c-6-diphenyl-t-3-methyl-N-methylpiperidin-r-4-ol 

Downstream Products

• 80771-42-2 1-cyano-3e-methyl-2e,6e-diphenyl-4-piperidone 
• 87731-89-3 1,3-Dimethyl-2,4,6,8-tetraphenyl-3,7-diazabicylo<3.3.1>nonan-9-one 
• 127895-95-8 C₁₉H₁₈⁽²⁾H₃NO 
• 37418-38-5 VUF₁₄₁₆₁ 

Relevant articles and documents

Synthesis, characterization and antitumor activities of some novel thiazinones and thiosemicarbazones derivatives

Two series of thiazinone and thiosemicarbazone derivatives (1-12) were synthesized using 2,4-diaryl-3-azabicyclo[3.3.1]nonan-9-ones (ABNs) and 3–alkyl–2,6–diarylpiperidin–4–ones as the starting materials. The structures of newly synthesized compounds were established on the basis of FT–IR, NMR spectroscopy and mass spectrometry. From the spectroscopic data, we identified that the cyclization reaction of thioamide with dialkyl acetylenedicarboxylate selectively gives six membered methyl 2-(2-(2,4-disubstituted-3-azabicyclo[3.3.1]nonan-9-ylidene)hydrazinyl)-4-oxo-4H-1,3-thiazine-6-carboxylates (1-6). In order to investigate the antitumor activities of the synthesized compounds, in?vitro cytotoxicity studies were carried out using human prostate cancer cell lines. Tested compounds showed good/moderate activities against cancer cell lines and further investigation carried out by live/dead assay.

Synthesis, spectral and structural studies of alkyl 2-(3-alkyl-2,6-diarylpiperidin-4-ylidene)hydrazinecarboxylate derivatives: Crystal and molecular structure of methyl 2-(3-methyl-2,6-diphenylpiperidin-4-ylidene)hydrazinecarboxylate

An efficient synthetic route with good overall yields to synthesize alkyl 2-(3-alkyl-2,6-diarylpiperidin-4-ylidene)hydrazinecarboxylates (7-14) is reported. All the synthesized compounds were characterized by their analytical and spectral (IR, 1H, 13C and 2D NMR) data. Single crystal X-ray structural analysis of compound 7, evidences that the configuration about C=N double bond is syn to C5 carbon (E-form) and exists in normal chair conformation with equatorial orientations of all the substituents.

Stereoselective synthesis, spectral and antimicrobial studies of some cyanoacetyl hydrazones of 3-alkyl-2,6-diarylpiperidin-4-ones

A series of novel cyanoacetyl hydrazones of 3-alkyl-2,6-diarylpiperidin-4-ones were synthesized stereoselectively and characterized by IR, Mass, 1H NMR, 13C NMR, 1H-1H COSY and 1H-13C COSY spectra. The stereochemistry of the synthesized compounds was established using NMR spectra. Antimicrobial screening of the synthesized compounds revealed their antibacterial and antifungal potencies. Growth inhibition of Enterobacter Aerogenes by compound 15 was found to be superior to the standard drug.