5558-93-0

Basic information

• Product Name: Benzeneacetonitrile, a-ethyl-a-methyl-
• CAS NO: 5558-93-0
• Molecular Formula: C11H13N
• Molecular Weight: 159.231
• Mol File: 5558-93-0.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: Benzeneacetonitrile, a-ethyl-a-methyl-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzeneacetonitrile, a-ethyl-a-methyl-(5558-93-0)
• EPA Substance Registry System: Benzeneacetonitrile, a-ethyl-a-methyl-(5558-93-0)

Safety Data

• Hazardous Substances Data: 5558-93-0(Hazardous Substances Data)

Upstream product

• 828-40-0 2-methyl-2-phenyl-butyric acid amide 
• 108-88-3 toluene 
• 75-03-6 ethyl iodide 
• 1823-91-2 1-phenylethyl cyanide 
• 140-29-4 phenylacetonitrile 
• 74-88-4 methyl iodide 
• 769-68-6 2-phenylbutanenitrile 

Downstream Products

• 4370-86-9 2-methyl-2-phenylbutyraldehyde 
• 83289-87-6 2-methyl-1,2-diphenyl-1-butanone 
• 51018-80-5 2-methyl-2-phenylbutanoic acid 
• 828-40-0 2-methyl-2-phenyl-butyric acid amide 
• 855389-15-0 dimethyl-[2-methyl-2-(4-nitro-phenyl)-butyl]-amine 
• 855388-69-1 2-methyl-2-(4-nitro-phenyl)-butylamine 
• 135-98-8 sec-Butylbenzene 
• 3979-27-9 2-methyl-2-phenyl-butylamine 
• 143-33-9 sodium cyanide 
• 3968-67-0 (-)-(2R)-2-Methyl-2-phenylbutanoic acid 
• 3968-68-1 (+)-(2S)-2-Methyl-2-phenylbutanoic acid 
• 157750-19-1 (-)-(2R)-2-Methyl-2-phenylbutanoyl chloride 

Relevant articles and documents

Surprising and Highly Efficient Use of Methylmagnesium Chloride as a Non-Nucleophilic Base in the Deprotonation and Alkylation of sp3 Centres Adjacent to Nitriles

Methylmagnesium chloride (MeMgCl) is a key reagent in research and industry typically as a nucleophile. In this article we develop the use of MeMgCl as a non-nucleophilic base in conjunction with catalytic amounts of an amine mediator. Specifically, we use the base to deprotonate α to a variety of nitriles in alkylation reactions, applying it to the synthesis of a wide variety of tertiary and quaternary nitriles, including examples where we successively and successfully added three different substituents on the carbon α to the nitrile. This method is generally applicable, high yielding and much greener than existing methods, and it has considerable advantages for industrial application.

1,1,1-TRIFLUORO-4-PHENYL-4-METHYL-2-(1H-PYRROLO

Compounds of Formula (IA), IB), IC), and (ID) wherein R1, R2, R3, R4, R5, and R6 are as respectively defined herein for Formula (IA), (IB), (IC), and (ID), or a tautomer, prodrug, solvate, or salt thereof; pharmaceutical compositions containing such compounds, and methods of modulating the glucocorticoid receptor function and methods of treating disease-states or conditions mediated by the glucocorticoid receptor function or characterized by inflammatory, allergic, or proliferative processes in a patient using these compounds.

Oxidative nucleophilic substitution of hydrogen in nitroarenes with phenylacetonitrile derivatives

Tertiary carbanions generated from α-substituted phenylacetonitriles in liquid ammonia add to nitrobenzenes in the para position to form the corresponding σ(H)-adducts which are transformed, depending on the starting nitriles and the reaction conditions, to products of oxidative nucleophilic substitution of hydrogen, ONSH or vicarious nucleophilic substitution, VNS.