4370-86-9

Upstream product

• 56051-24-2 1,2-epoxy-2-methyl-1-phenyl-butane 
• 6006-75-3 (+/-)-2-methyl-2-phenyl-butanol-⁽¹⁾ 
• 5558-93-0 (+/-)-2-methyl-2-phenyl-butyronitrile 
• 108323-47-3 5-ethyl-5-phenyl-[1,3]dioxan-2-one 
• 73405-03-5 [2-Chloro-2-methyl-but-(E)-ylidene]-isopropyl-amine 
• 71-43-2 benzene 
• 343948-55-0 Isopropyl-[2-methyl-2-phenyl-but-(E)-ylidene]-amine 
• 59231-18-4 2-methyl-2-phenyl-3-vinyloxirane 
• 34713-70-7 2-Phenylpropanal 
• 62338-21-0 methyl 2-methyl-2-phenylbutanoate 
• 31508-44-8 2-phenylpropionic acid methyl ester 
• 1342886-82-1 C₁₁H₁₅BrO 
• 33215-90-6 isopropyl-(2-phenyl-propylidene)-amine 

Downstream Products

• 17024-02-1 9-ethyl-10-methylphenanthrene 
• 727376-41-2 2-ethoxy-4-methyl-4-phenylhex-2-enoic acid ethyl ester 

Relevant academic research and scientific papers

Br?nsted Acid-Catalyzed Intramolecular Hydroarylation of β-Benzylstyrenes

Using triphenylmethylium tetrakis(pentafluorophenyl)borate as a convenient Br?nsted acid precatalyst, β-(α,α-dimethylbenzyl)styrenes are shown to cyclize efficiently to afford a variety of new indanes that possess a benzylic quaternary center. The geminal dimethyl-containing quaternary center is proposed to be necessary to arm the substrate for cyclization through steric biasing.

CF3CO2ZnEt-mediated highly regioselective rearrangement of bromohydrins to aldehydes

A highly efficient and selective rearrangement reaction of bromohydrins to aldehydes mediated by CF3CO2ZnEt was described. The secondary and tertiary aldehydes were prepared under mild conditions in good to excellent yields (85-99%). The scope and limitations of this rearrangement process were also investigated.

1,1,1-TRIFLUORO-4-PHENYL-4-METHYL-2-(1H-PYRROLO

Compounds of Formula (IA), IB), IC), and (ID) wherein R1, R2, R3, R4, R5, and R6 are as respectively defined herein for Formula (IA), (IB), (IC), and (ID), or a tautomer, prodrug, solvate, or salt thereof; pharmaceutical compositions containing such compounds, and methods of modulating the glucocorticoid receptor function and methods of treating disease-states or conditions mediated by the glucocorticoid receptor function or characterized by inflammatory, allergic, or proliferative processes in a patient using these compounds.

1-PROPANOL AND 1-PROPYLAMINE DERIVATIVES AND THEIR USE AS GLUCOCORTICOID LIGANDS

Compounds of Formula (I) wherein R1, R2 R3, R4, R5, R6, and X are as defiend herein for Formula (IA) and Formula (IB), or a tautomer, prodrug, solvate, or salt thereof; pharmaceutical compositions containing such compounds, and methods of modulating the glucocoricoid receptor function and methods of treating disease-states or conditions mediated by the glucocorticoid receptor function or characterized by inflammatory, allergic, or proliferative processes in a patient using these compounds.

Ruthenium clay catalyzed chemoselective hydrogenation of unsaturated esters, epoxides, sulfones and phosphonates

Ru-clays were prepared using montmorillonite-PPh2 or montmorillonite-bpy and RuCl3·H2O. The clays obtained were found to be effective catalysts for the reduction of unsaturated esters, epoxides, sulfones and phosphonates.

Α-ARYLATION OF ALDEHYDES VIA Α-CHLOROALDIMINES

α-Chloroaldimines are arylated at the α-position under Friedel-Crafts conditions via the presumptive intermediacy of α-imidoylcarbenium ions.Aluminium (III)chloride in arenes cleanly converted α-chloro-α-phenylaldimines into α-aryl-α-phenylaldimines.Aliphatic α-chloroaldimines could only be converted into the corresponding α-arylaldimines in low to moderate yields due to a lower reactivity and a competitive side reaction, i.e. dehydrochlorination into 1-aza-1,3-dienes. α-Bromo- and α-iodoaldimines were also evaluated under the given Friedel-Crafts conditions but the results appeared to be negative.The formation of all reaction products (i.e. α-arylaldimines, 1-aza-1,3-dienes and indolines) from the reaction of α-chloroaldimines with arenes in the presence of Lewis acids could be explained by the intermediacy of α-imidoylcarbenium ions, the chemistry of which is discussed to some extent.

CATALYTIC DECARBONYLATION, HYDROACYLATION, AND RESOLUTION OF RACEMIC PENT-4-ENALS USING CHIRAL BIS(DITERTIARY-PHOSPHINE) COMPLEXES OF RHODIUM(I)

Attempts to decarbonylate racemic aldehydes catalytically using rhodium(I) complexes containing chiral di-tertiary-phosphine ligands are described.Incorporation of an alkenic moiety into the aldehyde, for subsequent probing of induced asymmetry by chiral shift reagents, leads instead to formation of optically active hydroacylated products via kinetic resolution of the precursor racemic aldehyde.For example, (RS)-2-methyl-2-phenylpent-4-enal (1a) yields, on treatment with Cl, 2-methyl-2-phenylcyclopentanone with up to 69percent e.e of the (-)-(S) optical isomer and remaining unreacted aldehyde which is possibly the enantiomerically pure (-)-(R) form.Extension of this cyclization reaction to a 3,3-disubstituted pent-4-enal similarly provides a synthesis for an optically active 3,3-disubstituted cyclopentanone.Decarbonylation by-products are also observed; those from 1a appear as E- and Z-2-phenylpent-2-ene.The cyclization of 1a is catalyzed also by Rh(chiraphos)(solvent)2+ but with lower e.e.

FRIEDEL-CRAFTS REACTION OF α-CHLOROALDIMINES : POSSIBLE INTERMEDIACY OF α-IMIDOYLCARBENIUM IONS

α-Chloroaldimines are arylated at the α-position under Friedel-Crafts conditions via intermediacy of α-imidoylcarbenium ions.