5558-95-2

Usage

Uses

Used in Pharmaceutical Synthesis:
2-(TRICHLOROMETHYL)QUINAZOLIN-4(3H)-ONE is used as a chemical intermediate for the synthesis of various pharmaceuticals, leveraging its quinazolinone structure and trichloromethyl group to contribute to the development of new drugs with potential therapeutic benefits.
Used in Agrochemical Synthesis:
In the agrochemical industry, 2-(TRICHLOROMETHYL)QUINAZOLIN-4(3H)-ONE is utilized as an intermediate in the creation of compounds designed to protect crops from pests and diseases, capitalizing on its ability to be modified and incorporated into a range of agrochemical products.
Used in Organic Synthesis as a Reagent:
2-(TRICHLOROMETHYL)QUINAZOLIN-4(3H)-ONE is employed as a reagent in organic synthesis for the introduction of the trichloromethyl moiety into other molecules, which can enhance the properties of these molecules for various applications, including the development of new materials and compounds with specific functionalities.
Used in Antiviral and Antimicrobial Applications:
Due to its demonstrated biological activities, 2-(TRICHLOROMETHYL)QUINAZOLIN-4(3H)-ONE is used in research and development for potential antiviral and antimicrobial agents, aiming to combat viral and bacterial infections, respectively. Its antiviral properties are of particular interest for the development of treatments against a range of viral diseases, while its antimicrobial attributes could contribute to the fight against antibiotic-resistant bacteria.

InChI:InChI=1/C9H5Cl3N2O/c10-9(11,12)8-13-6-4-2-1-3-5(6)7(15)14-8/h1-4H,(H,13,14,15)

Upstream product

• 3137-63-1 4-chloro-2-(trichloromethyl)quinazoline 
• 1769-24-0 2-methyl-4-quinazolone 
• 118-92-3 anthranilic acid 
• 62-53-3 aniline 
• 137538-47-7 2,2,2-Trichloro-N-phenyl-acetimidoyl isocyanate 

Downstream Products

• 3137-63-1 4-chloro-2-(trichloromethyl)quinazoline 
• 1427059-64-0 4-phenylethynyl-2-trichloromethyl-quinazoline 
• 1429045-89-5 C₂₃H₁₅Cl₃N₆S 
• 1429045-96-4 C₂₃H₁₄Cl₃N₃S 

Relevant academic research and scientific papers

Sonogashira cross-coupling reaction in 4-chloro-2- trichloromethylquinazoline series is possible despite a side dimerization reaction

We studied the Sonogashira coupling reaction between 4-chloro-2- trichloromethylquinazoline and various terminal alkynes, mainly in phenylacetylene series. A brief review of the literature shows that mono- or polybromo/chloromethylated substrates, especia

Targeting the human malaria parasite Plasmodium falciparum: In vitro identification of a new antiplasmodial hit in 4-phenoxy-2- trichloromethylquinazoline series

From the promising results we previously obtained in quinazoline series and to complete the evaluation of the in vitro antiplasmodial activity of original 2-trichloromethylquinazolines, we synthesized new quinazolines possessing a variously substituted phenoxy group at position 4 through a simple and efficient two-step-synthesis approach. The studies of their activity toward the multi-resistant W2 Plasmodium falciparum strain and of their cytotoxicity on the human hepatocyte HepG2 cell line highlighted a hit compound (molecule 7) displaying a W2 IC50 value of 1.1 μM and a HepG2 CC50 value of 50 μM, comparable to chloroquine and doxycycline. Structure-activity- and toxicity relationships indicate that the trichloromethyl group plays a key role in the antiplasmodial activity of such chemical scaffold and also that the phenoxy group substitution as a direct influence on the molecules selectivity. Moreover, molecule 7 displays significant specific activity against the Plasmodium genus in comparison with Toxoplasma and does not show any mutagenic property at the Ames test.

QUINAZOLINE DERIVATIVES FOR THE TREATMENT AND PREVENTION OF DIABETES AND OBESITY

The present invention relates to novel quinazoline derivatives effective in lowering blood glucose level and body weight, and a medicine for treatment and/or prevention of diabetes and/or obesity, which comprises the compound as an active ingredient.