55601-20-2

Usage

Uses

Used in Pharmaceutical Industry:
Benzeneethanamine, b-fluorois used as a reactant for the preparation of fluoro amines, which are important intermediates in the synthesis of pharmaceutical compounds. The reaction of aziridines with hydrogen fluoride in pyridine solution allows for the production of these valuable building blocks, which can be further utilized in the development of novel drugs with improved properties, such as enhanced bioavailability, selectivity, and reduced side effects.
Used in Chemical Synthesis:
In the field of chemical synthesis, Benzeneethanamine, b-fluoroserves as a versatile building block for the creation of a wide range of fluorinated organic compounds. These compounds find applications in various industries, including agrochemicals, materials science, and specialty chemicals. The presence of the fluorine atom in the molecule can significantly influence the reactivity, stability, and physical properties of the resulting products, making them suitable for specific applications.
Used in Research and Development:
Benzeneethanamine, b-fluorois also utilized in research and development settings, where it can be employed as a starting material or a synthetic intermediate for the exploration of new chemical reactions and the development of innovative molecular structures. Benzeneethanamine, b-fluoro-'s unique properties make it an attractive candidate for studying the effects of fluorination on molecular behavior and reactivity, contributing to the advancement of chemical knowledge and the discovery of new applications.

Upstream product

• 10036-43-8 α-(Fluorophenyl)acetonitrile 
• 1499-00-9 2-phenylaziridine 
• 115046-20-3 phenyl-2 fluoro-2 azido-1 ethane 
• 2932-58-3 2-fluoro-2-phenylethanol 
• 70789-41-2 2-fluoro-2-phenylethyl-4-methylbenzene sulphonate 

Downstream Products

• 1338350-73-4 C₂₀H₁₉FN₂O₄ 
• 1338350-74-5 C₂₃H₂₅FN₂O₄ 

Relevant academic research and scientific papers

Iron(II)-Catalyzed Intermolecular Aminofluorination of Unfunctionalized Olefins Using Fluoride Ion

We herein report a new catalytic method for intermolecular olefin aminofluorination using earth-abundant iron catalysts and nucleophilic fluoride ion. This method tolerates a broad range of unfunctionalized olefins, especially nonstyrenyl olefins that are incompatible with existing olefin aminofluorination methods. This new iron-catalyzed process directly converts readily available olefins to internal vicinal fluoro carbamates with high regioselectivity (N vs F), many of which are difficult to prepare using known methods. Preliminary mechanistic studies demonstrate that it is possible to exert asymmetric induction using chiral iron catalysts and that both an iron-nitrenoid and carbocation species may be reactive intermediates.

Fluorinated cannabinoid CB2 receptor ligands: Synthesis and in vitro binding characteristics of 2-oxoquinoline derivatives

Cannabinoid receptor 2 (CB2) plays an important role in human physiology and the pathophysiology of different diseases, including neuroinflammation, neurodegeneration, and cancer. Several classes of CB2 receptor ligands, including 2-oxoquinoline derivatives, have been previously reported. We report the synthesis and results of in vitro receptor binding of a focused library of new fluorinated 2-oxoquinoline CB2 ligands. Twelve compounds, 13-16 18, 19, 21-24, 27, and 28 were synthesized in good yields in multiple steps. Human U87 glioma cells expressing either hCB1 (control) or hCB2 were generated via lentiviral transduction. In vitro competitive binding assay was performed using [3H]CP-55,940 in U87hCB1 and U87hCB2 cells. Inhibition constant (Ki) values of compounds 13-16, 18, 19, 21-24, 27, and 28 for CB2 were >10,000, 2.8, 5.0, 2.4, 22, 0.8, 1.4, >10,000, 486, 58, 620, and 2400 nM, respectively, and those for CB1 were >10,000 nM. Preliminary in vitro results suggest that six of these compounds may be useful for therapy of neuropathic pain, neuroinflammatory diseases and immune disorders. In addition, compound 19, with its subnanomolar Ki value, could be radiolabeled with 18F and explored for PET imaging of CB2 expression.

SELECTIVE REDUCTION OF β-FLUOROAZIDES TO β-FLUOROAMINES

Three methods were tested to reduce chemoselectively β-fluoroazides into β-fluoroamines : catalytic hydrogenation, catalytic transfer hydrogenation, and reduction with triphenyl phosphine.The last was the best.

Preparation of Fluoro Amines by the Reaction of Aziridines with Hydrogen Fluoride in Pyridine Solution

Hydrogen fluoride combines regiospecifically with aziridines (1) to give 2-fluoro amines (6) in good yields.Fluorine attack is in all cases completely directed to the most substituted ring carbon or to the benzylic carbon.The results, for benzylic aziridi