115046-20-3Relevant academic research and scientific papers
Palladium-Catalyzed Intermolecular Oxidative Diazidation of Alkenes
Peng, Haihui,Yuan, Zheliang,Chen, Pinhong,Liu, Guosheng
, p. 876 - 880 (2017/06/27)
A palladium-catalyzed oxidative vicinal diazidation of alkenes has been developed, in which TMSN3 was used as azide source. Both styrenes and unactivated alkenes are suitable for this reaction. And trans-alkyldiazides were obtained as major products from cyclic alkenes with moderate to good diastereoselectivities. This reaction afforded an efficient way for the synthesis of useful 1,2-diamines after hydrogenation.
FLUORO-2 PHENYL-2 AMINO-1 ETHANE: OBTENTION DES ENANTIOMERES, CONFIGURATION ABSOLUE ET EMPLOI COMME AGENT CHIRAL DE DERIVATION
Hamman, S.
, p. 377 - 388 (2007/10/02)
2-Fluoro-2-phenyl-1-aminoethane was synthesized from styrene.The enantiomers were separated and their absolute configurations were determined: the specific rotation of the amine with an R configuration is D20=-37.7 deg in methanol.This amine
SYNTHESIS OF β-FLUOROAZIDES : A ROUTE TO PRIMARY β-FLUORO AMINES
Benaissa, T.,Hamman, S.,Beguin, C.G.
, p. 163 - 174 (2007/10/02)
Two ways for the synthesis of β-fluoroazides are presented.The first one uses 1,2,2-trifluoro-2-chloro triethylamine (FAR) as a fluorinating reagent on the corresponding azidoalcohols.It is a smooth reaction at room temperature, but is not stereospecific ; it works well for phenyl substituted or primary α-carbon β-fluoroazides.The second route is the substitution of the azide group for bromine on an appropriate fluorobromide in phase transfer conditions.It is stereospecific (except for one case).It works well to give pure diastereoisomers of β-fluoroazides with pseudo primary (with deuterium) or secondary α-carbon atoms.
