2932-58-3

Basic information

• Product Name: B-FLUORO-BENZENEETHANOL
• Synonyms: B-FLUORO-BENZENEETHANOL;2-fluoro-2-phenylethanol;Benzeneethanol, b-fluoro-
• CAS NO: 2932-58-3
• Molecular Formula: C₈H₉FO
• Molecular Weight: 140.1548632
• Mol File: 2932-58-3.mol
• Article Data: 18

Chemical Properties

• Appearance: /
• CAS DataBase Reference: B-FLUORO-BENZENEETHANOL(CAS DataBase Reference)
• NIST Chemistry Reference: B-FLUORO-BENZENEETHANOL(2932-58-3)
• EPA Substance Registry System: B-FLUORO-BENZENEETHANOL(2932-58-3)

Safety Data

• Hazardous Substances Data: 2932-58-3(Hazardous Substances Data)

Upstream product

• 1786-36-3 (2-bromo-1-fluoroethyl)benzene 
• 96-09-3 styrene oxide 
• 67-56-1 methanol 
• 33315-78-5 2-acetoxy-1-fluoro-1-phenylethane 

Downstream Products

• 131508-80-0 C₁₇H₁₈F₂O₂ 
• 261518-58-5 ethyl (E)-4,4-difluoro-4-phenylbut-2-enoate 
• 66679-47-8 N-Methyl-2-fluor-2-phenylethylamin 
• 115046-20-3 phenyl-2 fluoro-2 azido-1 ethane 
• 14204-09-2 N_.N-Dimethyl-2-fluor-2-phenyl-aethylamin 
• 55601-20-2 β-fluoro-β-phenylamine 
• 696-31-1 α-fluorostyrene 
• 13344-76-8 α-fluorobenzeneacetaldehyde 
• 79186-50-8 fluoro-1, methoxy-2, phenyl-1 ethane 
• 126434-49-9 [1-Fluoro-2-(2-fluoro-ethoxy)-ethyl]-benzene 
• 108788-73-4 trans-3-chloroallyl 2,3-epoxypropyl ether 
• 128367-32-8 2-(2-Fluoro-2-phenyl-ethoxymethyl)-oxirane 
• 556-52-5 oxiranyl-methanol 
• 70789-41-2 2-fluoro-2-phenylethyl-4-methylbenzene sulphonate 

Relevant articles and documents

Synthesis of [18 F]-γ-Fluoro-α,β-unsaturated Esters and Ketones via Vinylogous 18 F-Fluorination of α-Diazoacetates with [18 F]AgF

This communication reports a method for the vinylogous radiofluorination of α-diazoacetates to generate [18 F]-γ-fluoro-α,β-unsaturated esters and ketones in moderate to good radiochemical yields. The method uses no-carrier-added [18 F]AgF and is compatible with aromatic and non-aromatic substrates and a number of different functional groups. The labeling method is showcased in the synthesis of a fluorinated cholest-5-en-3-one derivative as well as a difluorinated product pertinent to drug discovery.

β-fluoroamphetamines via the stereoselective synthesis of benzylic fluorides

A range of substituted aryl epoxides undergo efficient ring-opening hydrofluorination upon treatment with 0.33 equiv of BF3-OEt 2 in CH2Cl2 at -20 -°C to give the corresponding syn-fluorohydrins, consistent with a mechanism involving a stereoselective SN1-type epoxide ring-opening process. The benzylic fluoride products of these reactions are valuable templates for further elaboration, as demonstrated by the preparation of a range of aryl-substituted β-fluoroamphetamines.

Boron trifluoride-induced reactions of phenylglycidyl ethers: A convenient synthesis of enantiopure, stereodefined fluorohydrins

Ring-opening hydrofluorination of enantiomerically pure (2S,3S)-3-arylglycidyl ethers (aryl=phenyl, 4-trifluoromethylphenyl) by boron trifluoride-diethyl ether under mild conditions provides β-fluoro alcohols in good yield in a stereospecific manner with