55682-29-6Relevant academic research and scientific papers
Microwave assisted synthesis of 2,3-diaryl-6,7-dihydro-5H-pyrrolo[1,2 a]imidazoles through direct condensation of aryl 1,2-diketones and l-proline under solvent-free condition
Maity, Subhendu,Pathak, Sudipta,Pramanik, Animesh
, p. 2528 - 2532 (2013/06/26)
Microwave irradiation of a solid mixture of aryl 1,2-diketones, l-proline, and ammonium acetate (excess) for 15 min produces 2,3-diaryl-6,7-dihydro-5H- pyrrolo[1,2-a]imidazoles in moderate yields. Mechanistically this one-pot three-component reaction generates pyrroloimidazoles through the intramolecular cyclization of 1,2-diimine intermediates derived from the condensation of aryl 1,2-diketones, l-proline, and ammonia in 1:1:1 molar proportion. The significant advantages of this methodology are cost-effectiveness, operational simplicity, and reduced reaction time.
Synthesis of annelated imidazoles and benzimidazoles
McClure, James R.,Custer, John H.,Schwarz, H. Dean,Lill, Deborah A.
, p. 710 - 712 (2007/10/03)
A variety of fused ring imidazole or benzimidazole derivatives were prepared through two successive condensations of a dihalide with 4,5- diphenylimidazole or benzimidazole. The 2-methyl substituted derivatives of 4,5-diphenylimidazole or benzimidazole were also used. The size of the annelated ring, which is dependent on the dihalide used, can be varied from five to seven atoms. Initially, N-alkylhalo derivatives were prepared by condensation of the heterocyclic starting materials with a dihalide. Ring closure was then effected through intramolecular condensation of a carbanion derived from the 2-position or the 2-methyl group of the parent heterocyclic ring with the N-alkylhalo moiety.
4,5-DIPHENYLIMIDAZOLES FROM THE CYCLIZATION OF BENZIL N-ALKYLMONOHYDRAZONES
Collibee, William L.,Anselme, Jean-Pierre
, p. 655 - 662 (2007/10/02)
The thermal cyclization of monodisubstituted hydrazones (1) affords the corresponding N-substituted-4,5-diphenylimidazoles in good to excellent yields; possible mechanisms for this unusual cyclization are presented.
