55712-24-8

Basic information

• Product Name: 2-(4'-chlorophenyl)-3-phenylquinolin-4(1H)-one
• Synonyms: 2-(4'-chlorophenyl)-3-phenylquinolin-4(1H)-one
• CAS NO: 55712-24-8
• Molecular Weight: 331.801
• Mol File: 55712-24-8.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 2-(4'-chlorophenyl)-3-phenylquinolin-4(1H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4'-chlorophenyl)-3-phenylquinolin-4(1H)-one(55712-24-8)
• EPA Substance Registry System: 2-(4'-chlorophenyl)-3-phenylquinolin-4(1H)-one(55712-24-8)

Safety Data

• Hazardous Substances Data: 55712-24-8(Hazardous Substances Data)

Upstream product

• 1885-29-6 anthranilic acid nitrile 
• 100-44-7 benzyl chloride 
• 835-38-1 1-(2-aminophenyl)-2-phenylethanone 
• 873-76-7 para-Chlorobenzyl alcohol 
• 78396-10-8 2-(4’-chlorophenyl)-4-quinolone 
• 100-63-0 phenylhydrazine 
• 1148108-56-8 2-(4-chlorophenyl)-4-methoxy-3-phenylquinoline 

Relevant articles and documents

One-Pot Synthesis of 4-Quinolone via Iron-Catalyzed Oxidative Coupling of Alcohol and Methyl Arene

Herein, we describe the iron(III)-catalyzed oxidative coupling of alcohol/methyl arene with 2-amino phenyl ketone to synthesize 4-quinolone. Alcohols and methyl arenes are oxidized to the aldehyde in the presence of an iron catalyst and di-tert-butyl peroxide, followed by a tandem process, condensation with amine/Mannich-type cyclization/oxidation, to complete the 4-quinolone ring. This method tolerates various kinds of functional groups and provides a direct approach to the synthesis of 4-quinolones from less functionalized substrates.

2-aryl-4-chloro-3-iodoquinolines as substrates for the synthesis of 2,3-diaryl-4-methoxyquinolines

Sequential functionalisation of 2-aryl-4-chloro-3-iodoquinolines via palladium-catalysed cross-coupling with phenylboronic acid followed by displacement of the 4-chloro atom from the resulting 2,3-diaryl-4- chloroquinolines with methoxide ion yielded 2,3-