55849-69-9

Usage

Uses

Used in Flame Retardants:
Diethyl 3-hydroxypropylphosphonate is used as a flame retardant to enhance the fire resistance of materials, providing safety and protection in various industries.
Used in High-Performance Plastics and Polymers Production:
Diethyl 3-hydroxypropylphosphonate is used as a component in the production of high-performance plastics and polymers, contributing to their enhanced properties and performance.
Used in Pharmaceuticals:
Diethyl 3-hydroxypropylphosphonate is used as a pharmaceutical intermediate, playing a crucial role in the synthesis of various pharmaceutical compounds.
Used in Agrochemicals:
Diethyl 3-hydroxypropylphosphonate is used as an intermediate in the production of agrochemicals, aiding in the development of effective and efficient products for agricultural applications.
Used as a Chelating Agent in Metal Ion Removal Processes:
Diethyl 3-hydroxypropylphosphonate is used as a chelating agent for metal ion removal processes, helping to purify and treat water and other solutions.
Used in Environmental Remediation:
Diethyl 3-hydroxypropylphosphonate has been studied for its potential use in environmental remediation, contributing to the development of solutions for cleaning up pollutants and contaminants.
Used as a Reagent in Chemical Synthesis:
Diethyl 3-hydroxypropylphosphonate is used as a reagent in chemical synthesis, facilitating various chemical reactions and processes in research and industry.

Upstream product

• 1186-23-8 acetic acid 3-(diethoxyphosphoryl)propyl ester 
• 1186-10-3 diethyl 3-(bromopropyl)phosphonic acid 
• 3699-67-0 ethyl 3-(diethoxyphosphoryl)propanoate 
• 762-04-9 Diethyl phosphonate 
• 4402-24-8 diethyl 3-aminopropan-1-ylphosphonate 
• 71648-27-6 2-ethylhexanic acid tert-butyl ester 
• 67-56-1 methanol 
• 682-30-4 Diethyl vinylphosphonate 

Downstream Products

• 684286-29-1 C₃₈H₃₆FN₂O₇P 

Relevant academic research and scientific papers

Process for preparing sulfonamide compounds

The invention relates to a process for preparing sulfonamide compounds. The sulfonamide compound is an inhibitor of Bcl-2/Bcl-xL and is prepared from a compound (3R)-1-(3-(4-(4-(4-(3-(2-(4-chlorphenyl)-1-isopropyl-4-methylsulfonyl-5-methyl-1H-pyrrole-3-yl

PROCESS FOR PREPARING SULFONAMIDE COMPOUNDS

Provided are a process for preparing a sulfonamide compound which is an inhibitor of Bcl-2/Bcl-xL, including the compound (3R) -1- (3- (4- (4- (4- (3- (2- (4-chlorophenyl) -1-isopropyl-4-methylsulfonyl-5-methyl-1H-pyrrol-3-yl) -5-fluorophenyl) piperazine

A Bond-Weakening Borinate Catalyst that Improves the Scope of the Photoredox α-C-H Alkylation of Alcohols

The development of catalyst-controlled, site-selective C(sp 3)-H functionalization reactions is currently a major challenge in organic synthesis. In this paper, a novel bond-weakening catalyst that recognizes the hydroxy group of alcohols through formation of a borate is described. An electron-deficient borinic acid-ethanolamine complex enhances the chemical yield of the α-C-H alkylation of alcohols when used in conjunction with a photoredox catalyst and a hydrogen atom transfer catalyst under irradiation with visible light. This ternary hybrid catalyst system can, for example, be applied to functional-group-enriched-peptides.

COMPOUND, SURFACE TREATMENT AGENT, AND SURFACE TREATMENT METHOD

PROBLEM TO BE SOLVED: To provide a novel compound which is suitable for use as a surface treatment agent and has high stability, a surface treatment agent containing the compound, and a surface treatment method. SOLUTION: The compound is represented by formula (I) (R1 to R4 are each independently H, an alkyl group, or an alkoxy group which may have a perfluoroalkyl group as a substituent; R5 is H or a C1-6 alkyl group which may have a halogen atom as a substituent; X is a group represented by -OCONH-, -OCOS-, -OCOO-, -NH-, -S-, -O-, or -OCO-; when X is other than -OCO-, R6 is an alkylene group; and when X is -OCO-, R6 is a single bond or an alkylene group). SELECTED DRAWING: Figure 1 COPYRIGHT: (C)2017,JPOandINPIT

Synthesis of methacrylate-functionalized phosphonates and phosphates with long alkyl-chain spacers and their self-aggregation in aqueous solutions

Polymerizable amphiphilic organophosphorous compounds were synthesized and their self-aggregation behavior was investigated. The studied molecules contain a hydrophilic phosphorus end group, an alkyl chain spacer with a variable length from 3 to 11 CH2 groups and a polymerizable methacrylic group at the other chain end. Thus, the molecules represent a class of polymerizable surfactants. Two different reaction methods were used; either unsaturated alcohols or bromine-containing alcohols were applied as starting compounds for the preparation of the organophosphorous surfactants. The self-aggregation and micelle formation of the prepared compounds were investigated in aqueous solution by dynamic light scattering measurements. The critical micelle concentration of the P-containing amphiphiles was in all cases smaller than 0.040 mol/l and strongly dependent on the polarity of the phorphorous head group and the chain length of the spacer. Graphical abstract: [Figure not available: see fulltext.] The synthesis of organophosphorous amphiphiles as surface active monomers for the modification of metal oxide surfaces is presented. The spacer between the phosphorous head group and the methacrylate group was varied with regard to their length and composition. The self-aggregation behavior of these methacrylate-functionalized phosphates and phosphonates surfactants was investigated.

PHOSPHONATE ANALOGS OF HIV INTEGRASE INHIBITOR COMPOUNDS

Novel HIV integrase inhibitor compounds having at least one phosphonate group, protected intermediates thereof, and methods for inhibition of HIV-integrase are disclosed.

PRE-ORGANIZED TRICYCLIC INTEGRASE INHIBITOR COMPOUNDS

Tricyclic compounds according to the structure below, protected intermediates thereof, and methods for inhibition of HIV-integrase are disclosed. Formula (I). Al and A2 are moieties forming a five, six, or seven membered ring. L is a bond or a linker connecting a ring atom of Ar to N. X is O, S, or substituted nitrogen. Ar is aryl or heteroaryl. Q is N, +NR, or CR4. The aryl carbons may be independently substituted with substituents other than hydrogen. The compounds may include prodrug moieties covalently attached at any site.

PHOSPHONATE DERIVATIVES OF LIPOPHILIC AMINES

This invention relates to a class of novel phosphonate derivatives of lipophilic amines which exhibit squalene synthase inhibition properties. More specifically the compounds are bis aryl cycloalkylamino and azacycloalkyl phosphonates. Compounds of this invention reduce levels of serum cholesterol in the body without significantly reducing mevalonic metabolite synthesis. This invention relates also to pharmacological compositions and method of treatment for lowering serum cholesterol levels using the compounds of this invention.

Synthesis of acyclonucleoside phosphonates as antiviral agents against cytomegalovirus

Phosphonic acid analogs of ACV and DHPG that are isosteric with ACV phosphate and DHPG phosphate have been synthesized and evaluated for antiviral activity against human, murine, and guinea pig strains of cytomegalovirus. The phosphonates showed high activity against all of the strains. They were also evaluated against a DHPG resistant strain of human cytomegalovirus. Although the activity dropped considerably, significant antiviral activity was still evident.